1RJB - chain A | Fms related tyrosine kinase 3
Structure information
| PDB: | 1RJB |
| PubMed: | 14759363 |
| Release date: | 2004-02-03 |
| Resolution: | 2.1 Å |
| Kinase: | FLT3 |
| Family: | PDGFR |
| Group: | TK |
| Species: | HUMAN |
| Quality Score: | 7.2 |
| Missing Residues: | 0 |
| Missing Atoms: | 0 |
| DFG conformation: | out |
| αC-helix conformation: | in |
| Salt bridge KIII.17 and EαC.24: | Yes (2.6Å) |
| ASP rotation (xDFG.81) : | 176° |
| PHE rotation (xDFG.82) : | 203° |
| Activation loop position: | 3.8Å |
| αC-helix position: | 19Å |
| G-rich loop angle: | 61.9° |
| G-rich loop distance: | 19.1Å |
| G-rich loop rotation: | 44.5° |
2D & 3D views
Binding pocket waters
The following waters were found in the defined clusters:
I1
H-bond protein
I6
No H-bonds
I9
H-bond protein
Binding pocket sequence
| Uniprot | KVLGSGAFGKVMNVAVKMLALMSELKMMTQLGENIVNLLGAYLIFEYCCYGDLLNYLRSFLEFKSCVHRDLAARNVLVICDFGLA |
| Structure: | KVLGSGAFGKVMNVAVKMLALMSELKMMTQLGENIVNLLGAYLIFEYCCYGDLLNYLRSFLEFKSCVHRDLAARNVLVICDFGLA |
Modified residues
No modified residues identified.