Drugs and clinical candidates

This overview is powered by the PKIDB1,2 from the Bonnet lab.
INN name Brand name Synonyms Approval year Phase KLIFS links Structures
AbemaciclibVerzenio
Verzenios
LY-2835219
LY2835219
20174


AbivertinibA610
AC-0010
AC0010
ACEA100610
EX-ACEA0010
3-


AbrocitinibPF-04965842 3-


AcalabrutinibCalquenceACP-196
20174-


AcalisibCAL-120 2-


Acumapimod 2-


AdavosertibAZD 1775
AZD-1775
AZD1775
MK-1775
2


AfatinibGilotrif
Giotrif
BIBW2992
20134


AfuresertibGSK-2110183
GSK-2110183C
GSK2110183C
2-


AgerafenibAB-024
AC-013773
CEP-32496
RXDX 105
RXDX-105
1-


AlectinibAlecensaAF802
CH5424802
RO-5424802
RO5424802

20154


AlisertibMLN 8237
MLN-8237
MLN8237
3


AllitinibALL-3
AST-1306
1-


AlmonertinibAmeile
HS-10296
2-


AlpelisibPiqrayBYL-719
NVP-BYL719
20194


AltiratinibDCC-2701
DP-5164
1-


AlvocidibFlavopiridol
HL 275
HMR 1275
L 86 8275
L-868275
MDL-107826A
NSC-649890
3


AmcasertibBBI503
2-


AmuvatinibHPK 56
HPK-56
HPK56
MP 470
MP-470
2-


AnlotinibAL 3818
AL-3818
AL3818
Altn
Apc i
Apcii
Atc i
Atcii
Focus v
Fu ke wei
4-


ApatinibRivoceranib
Aitan
Albumin paclitaxel
Capecitabine
Carboplatin
Cryoablation
Docetaxel
Egafur
Emozolomide
H20140103
NAVELBINE+AITAN
NO.
Oxaliplatin
Paclitaxol
Pemetrexed
SHR-1210
VP-16
Xelox
YN968D1
20144-


ApitolisibG-038390
G-038390.1
GDC-0980
GDC-0980.1
RG-7422
RG7422
2


AsciminibABL-001
ABL001
ABL001-NX
NVP-ABL001
3


AvapritinibAyvakit70C366
BLU-285
C-366
X-720776
X720776
20204-


AxitinibInlytaAG-013736
AG-13736
20124


BafetinibCNS-9
INNO-406
NS-187
2


BalamapimodMKI-833
1-


BarasertibAZD 1152
AZD-1152
AZD1152
3-


BaricitinibOlumiantINCB-28050
INCB028050
LY-3009104
20174


BemcentinibBGB 324
BGB324
CS-1046
HY-15150
KB-80319
QC-11751
R428
SYN-1131
W-5845
2-


BentamapimodAS-602801
PGL-5001
2-


BerzosertibM-6620
M6620
VE-822
VX-970
VX970
2-


BimiralisibNC-B5
NCB5
PI3K-IN-2
PQR-309
PQR309
2


BinimetinibMektoviARRY 438162
ARRY-162
ARRY-438162
MEK-162
MEK162
NVP-MEK162

20184-


BosutinibBosulifBosutinib monohydrate
SK-606
SKI-606

20124


BranebrutinibBMS-986195 1


BrepocitinibPF-06700841
2


BrigatinibAlunbrigAP-26113
AP26113
20174


BrivanibBMS-540215 3-


Brivanib AlaninateBMS-582664
BMS-582664-02
Brivanib l-alanine ester
3-


BuparlisibBKM-120
BKM-120NX
BKM120-NX
NVP-BKM-120
NVP-BKM120
3


CabozantinibCabometyx
Cometriq
BMS-907351
XL-184 FREE BASE
XL184


20124-


CanertinibCI-1033
3-


CapivasertibAZC5363
AZD 5363
AZD-5363
AZD5363
3


CapmatinibTabrectaINC-280
INC280
INCB-28060
INCB-28060 FREE BASE
NVP-INC280
NVP-INC280-NX
NYP-INC280-NX
20204-


CediranibRecentinAZD-2171
AZD2171
ZD-2171

3-


CenisertibAS-703569
R-763
1-


CeralasertibAZD6738 2-


Cerdulatinib 2.5-


CeritinibZykadiaLDK-378
LDK378
NVP-LDK-378-NX
NVP-LDK378-NX
20144


CobimetinibCotellicGDC-0973
RG 7420
RG-7421
XL-518

20154


CopanlisibAliqopaBAY 80-6946
BAY-80-6946
BAY80-6946
20174


CrenolanibARO 002
ARO-002
CP 868596
CP-868,596
CP-868596
3


CrizotinibXalkoriPF-02341066
PF-2341066
20114


DabrafenibTafinlarGSK-2118436
GSK-2118436A
GSK2118436
GSK2118436A
20134


DacomitinibVizimproDacomitinib hydrate
PF-00299804
20184


DactolisibBEZ-235
BEZ235
NVP-BEZ235
NVP-BEZ235-NX
2-


DanusertibPHA-739358
2


DasatinibDasatinib
Sprycel
BMS-354825
BMS-354825 HYDRATE
BMS-354825-03
Dasatinib hydrate
Dasatinib monohydrate
20064


DecernotinibAdelatinib
VRT-831509
VX-509
2


DefactinibPF-04554878
VS-6063
2


Delgocitinib 1


DerazantinibARQ 087
ARQ-087
ARQ087
2-


DezapelisibINCB040093
0-


DilmapimodGW-681323
SB-681323
SB681323
2-


DinaciclibMK-7965
SCH-727965
3


DoramapimodBIRB 796 BS
BIRB-796
BIRB-796 BS
2


DovitinibCHIR-258
GFKI-258
NVP-TKI258
TKI-258
3


DubermatinibTP 0903
TP-0903
1.5-


DuvelisibCopiktraINK-1147
INK-1197
IPI-145

20184-


EdicotinibJNJ-40346527
2-


Empesertib(-)-BAY-1161909
BAY 1161909
MPS1-IN-5
1


EncorafenibBraftoviLGX-818
NVP-LGX-818-NXA
NVP-LGX818
NVP-LGX818-NXA

20184-


EnsartinibX-396
3-


EntospletinibGS-9973
SYK INHIBITOR GS-9973
2


EntrectinibRozlytrekNMS-E628
RXDX-101
20194


EnzastaurinLY-317615
LY317615
3-


ErdafitinibBalversaJNJ-42756493

20194


ErlotinibTarcevaCP-358,774
CP-358774
CP-35877401
OSI-774
R-1415
RG-1415
RO-508231
20044


EvobrutinibM-2951
3


FamitinibSHR-1020 3-


FasudilAT 877
AT-877
HA 1077
HA-1077
ZK-258594
4


FedratinibInrebicSAR-302503
SAR302503
TG-101348
TG101348
201942TA (not in KLIFS)


FenebrutinibG-02599853
G02599853
GDC-0853
RG-7845
RG7845
RO-7010939
RO7010939
2


FilgotinibG146034
GLPG-0634
GLPG0634
3


FlumatinibHH-GV678
HHGV-678
4-


ForetinibEXEL-2880
GSK-089
GSK-1363089
GSK-1363089G
GSK1363089G
XL-880
XL880
2


Foslinanib 2-


FostamatinibTavalisseR-788
R-935788
R788 FREE ACID
R935788 FREE ACID
201842RC (not in KLIFS)


FruquintinibHMP-013
HMPL-013
3-


Futibatinib 3


GalunisertibLY-2157299
LY2157299
2-


GandotinibLY-2784544
LY2784544
2-


GedatolisibPF-05212384
PKI-587
2-


GefitinibIressaZD1839

20034


GilteritinibXospataASP-2215
ASP2215
20184


GlesatinibMG-90265
MG-90265X
MG90265
MG90265GLY
MG90265H9
MG90265X
MGCD-265
MGCD265
2-


GolvatinibE-7050
E7050
2


Henatinib 1-


IbrutinibImbruvicaCRA-032765
PC-32765
PCI 32765
PCI-32765
PCI-32765-00

20134


IcotinibConmanaBPI-2009H20114-


IdelalisibZydeligCAL-101
GS-1101
GS-11CAL-101
20144


IlginatinibNS-018 2-


IlorasertibABT-348, A-968660A-968660
A-968660.0
ABBOTT-968660
ABT-348
2-


ImatinibGleevecSTI-571

20014


InfigratinibBGJ-398
BGJ398
MVP-BGJ398
NVP-BGJ398
3


IpatasertibGDC-0068
RG-7440
RG7440
3


ItacitinibINCB-039110
INCB-39110
INCB039110
3-


LapatinibTykerb
Tyverb
GSK-572016
GW-2016
GW-572016
GW-572016X
GW572016
20074


LarotrectinibVitrakviARRY-470
LOXO-101
20184-


Lazertinib 3-


LeniolisibCDZ173-NX 2


LenvatinibKisplyx
Lenvima
E-7080
ER-203492-00
20154


LerociclibG1T38
G1T38 FREE BASE
1.5-


LestaurtinibA-154475
A-154475.0
CEP-701
KT-555
KT5555
SP-924
SP924
SPM-924
3-


LifirafenibBGB 283
BGB-283
1


LinifanibA-741439
ABT-869
AL-39324
RG-3635
3-


LinsitinibASP-7487
OSI-906
OSI-906AA
3-


LorlatinibLorbrenaPF-06463922

20184


LosmapimodGsk-ahab
GW-856553
GW-856553X
GW856553X
3-


LucitanibAL-3810
CO-3810
E-3810
S 80881
2


MasitinibKinavet
Masivet
AB-1010 3G65 (not in KLIFS)


MavelertinibPF-06747775
2


MerestinibLY-2801653
LY2801653
2


MidostaurinRydaptCGP 41251
NVP-PKC412
PKC 412
PKC-412
20174


MilciclibPHA 848125
PHA-848125
2


MiransertibARQ 092
ARQ 092 FREE BASE
ARQ-092
2


MomelotinibCYT-0387
CYT-11387
CYT-387
CYT387
GS-0387
3


MotesanibAMG 706 3


MubritinibTAK-165
1-


NaquotinibASP-8273
ASP8273
3


NazartinibEGF-816
EGF816
NVP-EGF816-NX
3


Neflamapimod745
VD-31
VD-31,745
VD-31745
VRT-031745
VX-745
2


NemiralisibGSK-2269557
GSK-2269557 FREE BASE
GSK-2269557A
GSK2269557A
2


NeratinibNerlynxCDP-820
HKI-272
WAY-179272
20174


NetarsudilRhopressaAR-11324 FREE BASE
AR-13324
20174-


NilotinibTasignaAMN 107
AMN107
20074


Ningetinib 1.5-


NintedanibOfev
Vargatef
BIBF 1120
BIBF-1120
BIBF1120
Intedanib
20144


OclacitinibJaki
PF-03394197
0-


OlmutinibBI 1482694
BI-1482694
HM-61713
HM61713
2-


OmipalisibGSK-2126458
GSK2126458
1


OnvansertibNMS-1286937
NMS-P937
PCM-075
2


OpaganibABC 294640
ABC-294640
2.5-


OrantinibNSC-702827
SU-6668
TSU-68
3


OsimertinibTagrissoAZD-9291
AZD-9291 FREE BASE
AZD9291
20154




PacritinibONX-0803
SB-1518
SB1518
36T3 (not in KLIFS)


PalbociclibIbrancePD-0332991

20154


PamapimodJTT-705
R-1503
R1503
RO-4402257
2


Panulisib 1-


ParsaclisibINCB-050465
INCB050465
2-


PazopanibVotrientGW78603420094-


PeficitinibASP-015K
ASP015K
JNJ-54781532
3


PelitinibEKB-569
WAY-EKB-569
2


PemigatinibPemazyreINCB05482820204-


PeposertibM-3814
Nedisertib
M3814
MSC 2490484A
MSC-2490484A
MSC2490484A
1-


PexidartinibTuralioCML-261
PLX-3397
PLX3397
20194


Pexmetinib 1-


PictilisibCDC-0941
GDC 0941
GDC-0941
RG-7321
2


PilaralisibSAR-245408
SAR245408
XL-147
XL147
2-


PimasertibAS703026
EMD 1036239
AS703026
MSC1936369A
MSC1936369A
AS703026
EMD 1036239
AS 703026
AS-703026
EMD 1036239
EMD-1036239
G-02443714
MSC-1936369A
MSC-1936369B
MSC1936369A; AS703026; EMD 1036239

2-


PonatinibIclusigAP2453420124


PoseltinibHM71224
LY3337641
2-


PoziotinibHM 781-36B
HM-781-36B
NOV-120101
2-


PralsetinibGavretoBLU-66720204-


PrexasertibLY2606368 2-


Pyrotinib 3-


QuizartinibAC-010220
AC-220
AC010220
AC220
ASP-2689
3


RabusertibIC-83
LY-2603618
LY2603618
2-


RadotinibIY5511 3-


RalimetinibLSN-2322600 FREE BASE
LSN2322600 FREE BASE
LY-2228820
LY2228820
LY22288220
2-


RavoxertinibGDC-0994
GDC0994
RG-7842
1


RebastinibDP-1919DCC-2036
DCC-2036 FREE BASE
2


RecilisibEx-RADON 01210
ON 01210.NA
ON-01210
1-


RefametinibBAY 869766
BAY 8697661
BAY-86-9766
BAY-869766
BAY-8697661
BAY86-9766
RDEA 119
RDEA-119
2VRA (not in KLIFS)


RegorafenibStivargaBAY 73-4506
BAY 73-4506 MONOHYDRATE
BAY-734506
20124-


RepotrectinibTRX-0005
0-


RibociclibKisqaliLEE-011
LEE-011A
LEE011
NVP-LEE011
20174


RigosertibON 01910 36FS (not in KLIFS)


Ripasudil 2-


RipretinibQinlockDCC-261820204-


Riviciclib 2-


RociletinibAVL-301
CNX-419
CO-1686
CS-1631
3


RogaratinibBAY-1163877 2-


Roniciclib 2


RuboxistaurinArxxantLY-333531
3


RuxolitinibJakafi
Jakavi
INC-424
INC424
INCB-018424
INCB-18424
INCB018424
20114RXT (not in KLIFS)


SamotolisibLY 3023414
LY-3023414
LY3023414
2-


SapanisertibINK-128
INK128
MLN-0128
MLN0128
TAK-228
2


SapitinibAZD-8931
AZD8931
2-


SaracatinibAZ-10353926
AZD-0530
AZD0530
3


SavolitinibAZD-6094
AZD6094
HMPL-504
Volitinib
3


Selatinib 1-


SeletalisibUCB-5857
UCB5857
2-


SeliciclibAL-39256
CYC-202
NSC-701554
2


SelitrectinibLOXO-195 1.5-


SelonsertibGS-4997 2


SelpercatinibRetevmoLOXO-292
LY3527723
WHO 10967
20204-


SelumetinibKoselugoARRY-142886
ARRY-886
AZD-6244
AZD6244
20204


SemaxanibNSC-696819
Semaxinib
SU-5416
SU005416
SU5416
3


SerabelisibAGN-PC-0DB6FL
INK1117
MLN-1117
MLN1117
TAK-117
2-


SilmitasertibCX 4945
CX-4945
CX4945
2


SimotinibSIM-6802 3-


SimurosertibTAK-931 2-


SitravatinibMG-516
MG-91516
MGCD-516
MGCD516
3-


SolcitinibG154578
GLPG-0778
GLPG-0788
GLPG0778
GSK-2586184
GSK-2586184A
GSK2586184A
2-


SonolisibPX-866 2-


SorafenibNexavarBAY 43-900620054


SotrastaurinAEB-071
AEB071
NVP-AEB071
2


SpebrutinibAVL-292
CC-292
2


SunitinibSutentSU-011248
SU-11248
SU011248
20064


SurufatinibHMPL-012
Sulfatinib
KDR-IN-1
3-


TafetinibSIM 010603
SIM-010603
1-


TalmapimodSCIO 469
SCIO-469
2


TamatinibR-406 2


TandutinibCT-53518
CT53518
MLN-0518
MLN-518
2-


TanzisertibCC-930
JNK 930
JNK-930
2


TarloxotinibTarloxotinib bromide 2-


TaselisibGDC-0032
RG-7604
3


TelatinibBAY 57-9352
BAY-57-9352
BAY-579352
2-


Tenalisib 2-


TepotinibEMD 1214063
EMD-1214063
MSC-2156119
MSC-2156119J
2


TesevatinibEXEL-7647
KD-019
KD-020
KD019
XL-647
XL647
3-


TheliatinibHMPL-309 1-


TirabrutinibGS-4059
ONO-4059
ONO-4059(FREE BASE)
2-


TivantinibARQ 197
ARQ-197
3TIV (not in KLIFS)




TivozanibFotivdaASP-4130
AV-951
KIL-8951
KIL8951
KRN-951
4


ToceranibPHA-291639 0BWC (not in KLIFS)


TofacitinibXeljanz550
CP 690550
CP- 690 550
CP-690
CP-690,550
CP-690,550 FREE BASE
CP-690-550
CP-690550
CP-690550 FREE BASE
CP690,550
CP690550
Tasocitinib
20124


TomivosertibEFT-508
EFT508
2


TozasertibMK-045
MK-0457
VX-68
VX-680
2


TrametinibMekinistGSK-1120212
GSK1120212
JTP 74057
JTP-74057
20134QOM (not in KLIFS)


TrilaciclibG1T28 2-


TucatinibTukysaARRY-380
ONT-380
20204-


Ulixertinib 2


UmbralisibRP-5264
RP5264
TGR 1202
TGR-1202 BASE
TGR-1202 FREE BASE
3-


UpadacitinibRinvoqABT-49420194-


UprosertibGSK-2141795
GSK-2141795C
GSK2141795
GSK2141795C
2-


VactosertibTEW 7197
TEW-7197
1.5-


VandetanibCaprelsa
Zactima
GNF-PF-2188
ZD-64
ZD6474


20114


VarlitinibAR-00334543
ARRY-334543
ARRY-543
ASLAN-001
ASLAN001
2.5-


VatalanibBAY-86-5127
CGP-79787
K-222584
NVP-PTK787
PTK-787
PTK787
ZK-222584
3-


VecabrutinibBIIB-062
BSK-4841
FP-0182
FP0182
SNS-062
1-


VemurafenibZelborafPLX-4032
PLX4032
RG 7204
RO 5185426
RO-51-85426
20114


VerosudilAR-12286
AR-12286 FREE BASE
2-


VistusertibAZD-2014
AZD2014
2-


VolasertibBI 6727
BI-6727
3


Vorolanib 1-


Voruciclib 2-


VoxtalisibSAR-245409
SAR245409
XL-765
2-


ZanubrutinibBrukinsaBGB-311120194


ZotiraciclibEX45
SB-1317
SB1317
TG-02
TG02
1-