Drugs and clinical candidates

This overview is powered by the PKIDB1,2 from the Bonnet lab.
INN name Brand name Synonyms Approval year Phase KLIFS links Structures
-AZD4547
AZD-4547
KB-74810
2

-PF-06873600 2

-AZD-8154
AZD8154
AZD 8154
2

-PF-06952229 1

-LY-3200882 2

-AR-13503
Metabolite netarsudil
1

-TT 00420
TT-00420
1

-DZD4205
AZD-4205
DZD 4205
1/2

-CLN-081
TAS6417
1/2

-BDTX-189 1

-BTX-A51 1

-IPN60130
BLU-782
1

-DAY101
MLN-2480
MLN2480
TAK580
TAK-580
1

-CA-4948 2

-GDC-0134 1

-JNJ-67856633
JNJ67856633
JNJ 67856633
2

-SHR0302
SHR 0302
3

-CFI-400945
CFI400945
CFI 400945
1

-LY3295668
AK-01
1

-KB-0742 1

-ON 123300 2

-PF-07104091 2

-M4205 1

AbemaciclibVerzenio
Verzenios
LY-2835219
LY2835219
2017 4


AbivertinibA610
AC-0010
AC0010
ACEA100610
Avitinib
EX-ACEA0010
3

AbrocitinibPF-04965842 3


AcalabrutinibCalquenceACP-1962017 4

AcalisibCAL-120
CAL120
GS-9820
GS9820
2

Acumapimod 2

AdavosertibAZD 1775
AZD-1775
AZD1775
MK-1775
MK1775
2


AfatinibGilotrif
Giotrif
BIBW-2992
BIBW2992
2013 4



AfuresertibASB-183
ASB183
GSK-2110183
GSK-2110183C
GSK2110183
GSK2110183C
2

AgerafenibAB-024
AC-013773
CEP-32496
RXDX 105
RXDX-105
1

AlectinibAlecensaAF-802
AF802
CH-5424802
CH5424802
RO-5424802
RO5424802
2015 4


AlisertibMLN 8237
MLN-8237
MLN8237
3


AllitinibALL-3
AST-1306
1

Alofanib 1

AlpelisibPiqrayBYL-719
NVP-BYL719
2019 4


AltiratinibDCC-2701
DP-5164
1

AlvocidibFlavopiridol
HL 275
HL-275
HMR 1275
HMR-1275
L 86 8275
L-868275
L86-8275
MDL 107,826A
MDL-107826A
NSC-649890
3


AmcasertibBBI-503
BBI503
2

AmuvatinibHPK 56
HPK-56
HPK56
MP 470
MP-470
MP470
2

ApatinibAitanRivoceranib
Albumin paclitaxel
Capecitabine
Carboplatin
Cryoablation
Docetaxel
Egafur
Emozolomide
H20140103
NAVELBINE+AITAN
NO.
Oxaliplatin
Paclitaxol
Pemetrexed
SHR-1210
VP-16
Xelox
YN968D1
2014 4

ApilimodLAM-002A
LAM002A
STA 5326
STA-5326
STA5326
2

ApitolisibG-038390
G-038390.1
GDC-0980
GDC-0980.1
RG-7422
RG7422
2


AsciminibABL-001
ABL001
ABL001-NX
NVP-ABL001
3


AtuveciclibBAY 1143572
BAY-1143572
BAY1143572
1

AumolertinibHS-10296
Almonertinib
3

AvapritinibAyvakit70C366
BLU-285
C-366
X-720776
X720776
2020 4

AxitinibInlytaAG-013736
AG-13736
2012 4


BafetinibCNS-9
INNO-406
NS-187
2


BalamapimodMKI-833 1

BarasertibAZD 1152
AZD-1152
AZD1152
3

BaricitinibOlumiantINCB-028050
INCB-28050
INCB028050
LY-3009104
LY3009104
2017 4


BelizatinibTSR-011
TSR011
2


BelvarafenibHM95573
GDC-5573
2


BemcentinibBGB 324
BGB-324
BGB324
CS-1046
HY-15150
KB-80319
QC-11751
R 428
R-428
R428
SYN-1131
SYN1131
W-5845
2

BentamapimodAS-602801
PGL-5001
2

BerzosertibM-6620
M6620
VE-822
VX-970
VX970
2

BimiralisibNC-B5
NCB5
PI3K-IN-2
PQR-309
PQR309
2


BinimetinibMektoviARRY 438162
ARRY-162
ARRY-438162
MEK-162
MEK162
NVP-MEK162
2018 4


BosutinibBosulifBosutinib monohydrate
SK-606
SKI-606
2012 4


BranebrutinibBMS-986195 2


BrepocitinibPF-06700841 2


BrigatinibAlunbrigAP-26113
AP26113
2017 4


BrivanibBMS-540215 3

Brivanib alaninateBMS-582664
BMS-582664-02
Brivanib l-alanine ester
3

BuparlisibBKM-120
BKM-120NX
BKM120-NX
NVP-BKM-120
NVP-BKM120
3


CabozantinibCabometyx
Cometriq
BMS-907351
XL-184
XL184
2012 4

CanertinibCI-1033 3

CapivasertibAZC5363
AZD 5363
AZD-5363
AZD5363
3


CapmatinibTabrectaINC-280
INC280
INCB-28060
NVP-INC280
NVP-INC280-NX
NYP-INC280-NX
2020 4

CatequentinibFOCUS VAL3818
Anlotinib
Altn
4

CediranibRecentinAZD-2171
AZD2171
ZD-2171
3

CenisertibAS-703569
R-763
1

CeralasertibAZD6738 2

Cerdulatinib 2.5

CeritinibZykadiaLDK-378
LDK378
NVP-LDK-378-NX
NVP-LDK378-NX
2014 4


CobimetinibCotellicGDC-0623
GDC-0973
RG 7420
RG-7420
RG-7421
RG7420
XL-518
2015 4


ConteltinibCT-707
CT707
1

CopanlisibAliqopaBAY 80-6946
BAY-80-6946
BAY80-6946
2017 4


CrenolanibARO 002
ARO-002
CP 868596
CP-868,596
CP-868596
3


CrizotinibXalkoriPF-02341066
PF-2341066
2011 4


DabrafenibTafinlarGSK-2118436
GSK-2118436A
GSK2118436
GSK2118436A
2013 4


DacomitinibVizimproDacomitinib hydrate
PF-00299804
2018 4


DactolisibBEZ-235
BEZ235
NVP-BEZ235
NVP-BEZ235-NX
3

DanusertibPHA-739358 2


DasatinibDasatinib
Sprycel
BMS-354825
BMS-354825 HYDRATE
BMS-354825-03
Dasatinib hydrate
Dasatinib monohydrate
2006 4


DecernotinibAdelatinib
VRT-831509
VX-509
2


DefactinibPF-04554878
VS-6063
2


Delgocitinib 2


DerazantinibARQ 087
ARQ-087
ARQ087
2

DezapelisibINCB040093 0

DilmapimodGW-681323
SB-681323
SB681323
2

DinaciclibMK-7965
SCH 727965
SCH-727965
3


DoramapimodBIRB 796 BS
BIRB-796
BIRB-796 BS
2


DovitinibCHIR-258
GFKI-258
NVP-TKI258
TKI-258
3


DubermatinibHCL-2084
TP 0903
TP-0903
TP0903
1.5

DuvelisibCopiktraINK-1147
INK-1197
IPI-145
2018 4

EdicotinibJNJ-40346527 2

ElimusertibBAY 1895344
BAY-1895344
BAY1895344
1

ElsubrutinibABBV 105 2

Empesertib(-)-BAY-1161909
BAY 1161909
MPS1-IN-5
1


EncorafenibBraftoviLGX-818
NVP-LGX-818-NXA
NVP-LGX818
NVP-LGX818-NXA
2018 4

EnsartinibX-396 3

EntospletinibGS-9973
SYK INHIBITOR GS-9973
2


EntrectinibRozlytrekNMS-E628
RXDX-101
2019 4


EnzastaurinLY-317615
LY317615
3

EpertinibS-222611 1

ErdafitinibBalversaJNJ-427564932019 4


ErlotinibTarcevaCP-358,774
CP-358774
CP-35877401
OSI-774
R-1415
RG-1415
RO-508231
2004 4


EvobrutinibM-2951 3


FadraciclibCYC-065
CYC065
1

FamitinibSHR-1020 3

FasudilAT 877
AT-877
HA 1077
HA-1077
ZK-258594
4


FedratinibInrebicSAR-302503
SAR302503
TG-101348
TG101348
2019 4


FenebrutinibG-02599853
G02599853
GDC-0853
RG-7845
RG7845
RO-7010939
RO7010939
2


FilgotinibJyselecaG-146034
G146034
GLPG-0634
GLPG0634
GS-6034
2021 (EMA, MHLW) 4


FisogatinibBLU-554
BLU 554
2


FlumatinibHH-GV678
HHGV-678
4

ForetinibEXEL-2880
GSK-089
GSK-1363089
GSK-1363089G
GSK089
GSK1363089G
XL-880
XL880
2


Fosifidancitinib I-538 ?

FoslinanibCVM-1118
TRX 818
TRX-818
2

FostamatinibTavalisseR-788
R-935788
R788
R935788
2018 4


FruquintinibHMP-013
HMPL-013
3

Futibatinib 3


GalunisertibLY-2157299
LY2157299
2

GandotinibLY-2784544
LY2784544
2

GedatolisibPF-05212384
PKI-587
2


GefitinibIressaZD-1839
ZD1839
2003 4


GilteritinibXospataASP-2215
ASP2215
2018 4


GlesatinibMG-90265
MG-90265X
MG90265
MG90265GLY
MG90265H9
MG90265X
MGCD-265
MGCD265
2

Glumetinib 1

GolvatinibE-7050
E7050
2


GusacitinibASN-002
ASN002
EN-3351
EN3351
2

Henatinib 1

IbrutinibImbruvicaCRA-032765
PC-32765
PCI 32765
PCI-32765
PCI-32765-00
2013 4



IcotinibConmanaBPI-2009H2011 (CFDA) 4

IdelalisibZydeligCAL-101
GS-1101
GS-11CAL-101
2014 4


IfidancitinibA 301
A-301
A301
R2010
2

IlginatinibNS-018 2

IlorasertibA-968660
A-968660.0
ABBOTT-968660
ABT-348
ABT-348, A-968660
2

ImatinibGleevecSTI-5712001 4


InavolisibGDC-0077
GDC0077
RO7113755
RG6114
2

InfigratinibTruseltiqBGJ-398
BGJ398
MVP-BGJ398
NVP-BGJ398
2021 4


IpatasertibGDC-0068
RG-7440
RG7440
3


ItacitinibINCB-039110
INCB-39110
INCB039110
3

ItacnosertibTP-0184
TP0184
1

IzencitinibTD 1473
TD1473
TD-1473
3

LanraplenibGS-9876 2


LapatinibTykerb
Tyverb
GSK-572016
GW-2016
GW-572016
GW-572016X
GW572016
2007 4


LarotrectinibVitrakviARRY-470
BAY-2757556
BAY2757556
LOXO-101
2018 4

LazertinibGNS-1480
GNS1480
JNJ-73841937
YH-25448
YH25448
3

LeniolisibCDZ173-NX 2


LenvatinibKisplyx
Lenvima
E-7080
ER-203492-00
2015 4


LerociclibG1T38 1.5

LestaurtinibA-154475
A-154475.0
CEP-701
KT-555
KT-5555
KT5555
SP-924
SP924
SPM-924
3

LifirafenibBGB 283
BGB-283
1


LinifanibA-741439
ABT-869
AL-39324
RG-3635
3

LinperlisibYY-20394
YY20394
3

LinsitinibASP-7487
OSI-906
OSI-906AA
3

LorecivivintAdavivint
SM0-4690
SM04690
2

LorlatinibLorbrenaPF-064639222018 4


Lorpucitinib 1

LosmapimodFTX-1821
FTX1821
Gsk-ahab
Gskahab
GW-856553
GW-856553X
GW856553X
3

LucitanibAL-3810
CO-3810
E-3810
S 80881
S-80881
2


MasitinibKinavet
Masivet
AB-1010 3


MavelertinibPF-06747775 2


MerestinibLY-2801653
LY2801653
2


MevociclibSY-1365
SY1365
1

MidostaurinRydaptCGP 41251
CGP-41251
NVP-PKC412
PKC 412
PKC-412
2017 4


MilciclibPHA 848125
PHA-848125
2


MiransertibARQ 092
ARQ-092
2


MirdametinibPD 0325901
PD-0325901
PD0325901
2

MivavotinibTAK-659F 2


MobocertinibTAK788
TAK-788
AP32788
3

MomelotinibCYT-0387
CYT-11387
CYT-387
CYT387
GS-0387
3


MotesanibAMG 706
AMG-706
3


MubritinibTAK-165 1

NaquotinibASP-8273
ASP8273
3


NazartinibEGF-816
EGF816
NVP-EGF816-NX
3


Neflamapimod745
VD-31
VD-31,745
VD-31745
VRT-031745
VX-745
2


NemiralisibGSK-2269557
GSK-2269557A
GSK2269557A
2


NeratinibNerlynxCDP-820
HKI-272
WAY-179272
2017 4


NetarsudilRhopressaAR-133242017 4

NilotinibTasignaAMN 107
AMN-107
AMN107
2007 4


Ningetinib 1.5

NintedanibOfev
Vargatef
BIBF 1120
BIBF-1120
BIBF1120
Intedanib
2014 4


OclacitinibJaki
PF-03394197
0

OlafertinibCK101
CK‐101
RX-518
RX518
1

OlmutinibBI 1482694
BI-1482694
HM-61713
HM61713
2

OlverembatinibHQP1351 GZD824 1.5

OmipalisibGSK-2126458
GSK2126458
1


OnatasertibATG-008
CC 223
CC-223
2

OnvansertibNMS-1286937
NMS-P937
PCM-075
2


OpaganibABC 294640
ABC-294640
2.5

OrantinibNSC-702827
SU-6668
TSU-68
3


OrelabrutinibICP022
ICP-022
2

OsimertinibTagrissoAZD-9291
AZD9291
Mereletinib
2015 4



PacritinibONX-0803
SB-1518
SB1518
3


PalbociclibIbrancePD-03329912015 4


PamapimodR-1503
R1503
RO 4402257
RO-4402257
2


PamufetinibTAS-115 2

Panulisib 1

ParsaclisibINCB-050465
INCB050465
2

PaxalisibGDC-0084
GDC0084
2

PazopanibVotrientGW7860342009 4

PeficitinibASP-015K
ASP015K
JNJ-54781532
3


PegcantratinibCT327 2

PelitinibEKB-569
WAY-EKB-569
2


PemigatinibPemazyreINCB0548282020 4

PeposertibM-3814
Nedisertib
M3814
MSC 2490484A
MSC-2490484A
MSC2490484A
1

PexidartinibTuralioCML-261
PLX-3397
PLX3397
2019 4


Pexmetinib 1

PictilisibCDC-0941
GDC 0941
GDC-0941
RG-7321
2


PilaralisibSAR-245408
SAR245408
XL-147
XL147
2

PimasertibAS 703026
AS-703026
AS703026
EMD 1036239
EMD-1036239
G-02443714
MSC-1936369A
MSC-1936369B
MSC1936369A
MSC1936369A
AS703026
EMD 1036239
2


PirtobrutinibLOXO-305 3

PonatinibIclusigAP-24534
AP24534
2012 4


PoseltinibHM71224
LY3337641
2

PoziotinibHM 781-36
HM 781-36B
HM-781-36
HM-781-36B
NOV-120101
2

PralsetinibGavretoBLU-123244
BLU-667
BLU123244
X-581238
X581238
2020 4


PrexasertibLY2606368 2

Pyrotinib 3

QuizartinibAC-010220
AC-220
AC010220
AC220
ASP-2689
3


RabusertibIC-83
LY-2603618
LY2603618
2

RadotinibIY5511 3

RalimetinibLSN-2322600
LSN2322600
LY-2228820
LY2228820
LY22288220
2

RavoxertinibGDC-0994
GDC0994
RG-7842
1


RebastinibDCC-2036
DP-1919
2


RecilisibEx-rad
ON 01210
ON 01210.NA
ON-01210
1

RefametinibBAY 869766
BAY 8697661
BAY-86-9766
BAY-869766
BAY-8697661
BAY86-9766
RDEA 119
RDEA-119
2


RegorafenibStivargaBAY 73-4506
BAY 73-4506 MONOHYDRATE
BAY-73-4506
BAY-734506
2012 4

RemibrutinibLOU064 2

RepotrectinibTPX-0005
TRX-0005
1

RezivertinibBPI 7711 3

RibociclibKisqaliLEE-011
LEE-011A
LEE011
LEE011A
NVP-LEE011
2017 4


RigosertibON 01910 3


RilzabrutinibPRN-1008
PRN1008
2

RimacalibSMP-114 2

Ripasudil 2

RipretinibQinlockDCC-26182020 4

RitlecitinibPF-06651600
PF06651600
3


Riviciclib 2

RoblitinibFGF-401
FGF401
NVP-FGF401
2


RociletinibAVL-301
CNX-419
CO-1686
CS-1631
3


RogaratinibBAY-1163877 2

Roniciclib 2


RuboxistaurinArxxantLY-333531 3


RuxolitinibJakafi
Jakavi
INC-424
INC424
INCB-018424
INCB-18424
INCB018424
2011 4


SamotolisibLY 3023414
LY-3023414
LY3023414
2

SamuraciclibCT7001
ICEC-0942
ICEC0942
PPDA-001
1

SapanisertibINK-128
INK128
MLN-0128
MLN0128
TAK-228
2


SapitinibAZD-8931
AZD8931
2

SaracatinibAZ-10353926
AZD-0530
AZD0530
3


SavolitinibAZD-6094
AZD6094
HMPL-504
Volitinib
3


Selatinib 1

SeletalisibUCB-5857
UCB5857
2

SeliciclibAL-39256
CYC-202
NSC-701554
2


SelitrectinibLOXO-195 1.5

SelonsertibGS-4997 2


SelpercatinibRetevmoLOXO-292
LY-3527723
LY3527723
WHO 10967
2020 4


SelumetinibKoselugoARRY-142886
ARRY-886
AZD-6244
AZD6244
2020 4


SemaxanibNSC-696819
Semaxinib
SU-5416
SU005416
SU5416
3


SerabelisibAGN-PC-0DB6FL
INK1117
MLN-1117
MLN1117
TAK-117
2

SeralutinibGB-002
Gb002
PK-10571
PK10571
2

SilmitasertibCX 4945
CX-4945
CX4945
2


SimotinibSIM-6802 3

SimurosertibTAK-931 2

SitravatinibMG-516
MG-91516
MGCD-516
MGCD516
3

SolcitinibG-154578
G154578
GLPG-0778
GLPG-0788
GLPG0778
GSK-2586184
GSK-2586184A
GSK2586184A
2

SonolisibPX-866 2

SorafenibNexavarBAY 43-9006
BAY-43-9006
2005 4


SotrastaurinAEB-071
AEB071
NVP-AEB071
2


SpebrutinibAVL-292
CC-292
2


SunitinibSutentSU-011248
SU-11248
SU011248
2006 4


SurufatinibHMPL-012
Sulfatinib
KDR-IN-1
3

TafetinibSIM 010603
SIM-010603
1

TalmapimodSCIO 469
SCIO-469
2


TamatinibR-406 2


TandutinibCT 53518
CT-53518
CT53518
MLN-0518
MLN-518
2

TanzisertibCC-930
JNK 930
JNK-930
2


TarloxotinibTarloxotinib bromide 2

TaselisibGDC-0032
RG-7604
3


TelatinibBAY 57-9352
BAY-57-9352
BAY-579352
2

Tenalisib 2

TepotinibTepmetkoEMD 1214063
EMD-1214063
EMD1214063
MSC-2156119
MSC-2156119J
MSC2156119
2021 4


TesevatinibEXEL-7647
KD-019
KD-020
KD019
XL-647
XL647
3

TheliatinibHMPL-309 1

TirabrutinibGS-4059
ONO-4059
2


TivantinibARQ 197
ARQ-197
3



TivozanibFotivdaASP-4130
AV-951
KIL-8951
KIL8951
KRN-951
2021 4


ToceranibPHA-291639 0


TofacitinibXeljanz550
CP 690550
CP- 690 550
CP-690
CP-690,550
CP-690-550
CP-690550
CP690,550
CP690550
Tasocitinib
2012 4


TolebrutinibBTK'168
PRN-2246
PRN2246
SAR442168
2

TomivosertibEFT 508
EFT-508
EFT508
2


TozasertibMK-045
MK-0457
VX-68
VX-680
2


TrametinibMekinistGSK-1120212
GSK1120212
JTP 74057
JTP-74057
TMT-212
TMT212
2013 4


TrilaciclibCoselaG1T282021 4

TucatinibTukysaARRY-380
ONT-380
2020 4

Ulixertinib 2


UmbralisibUkoniqRP-5264
RP5264
TGR 1202
TGR-1202
2021 4

UpadacitinibRinvoqABT-4942019 4

UprosertibGSK-2141795
GSK-2141795C
GSK2141795
GSK2141795C
2

VactosertibTEW 7197
TEW-7197
2

VandetanibCaprelsa
Zactima
GNF-PF-2188
ZD-64
ZD-6474
ZD6474
2011 4


VarlitinibAR-00334543
ARRY-334543
ARRY-543
ASLAN-001
ASLAN001
2.5

VatalanibBAY-86-5127
CGP-79787
K-222584
NVP-PTK787
PTK-787
PTK787
ZK-222584
3

VecabrutinibBIIB-062
BSK-4841
FP-0182
FP0182
SNS-062
1

VemurafenibZelborafPLX-4032
PLX4032
RG 7204
RG-7204
RO 5185426
RO-51-85426
RO-5185426
2011 4


VerosudilAR-12286 2

VimseltinibDCC-3014
DCC3014
2

VistusertibAZD-2014
AZD2014
2

VolasertibBI 6727
BI-6727
3


Vorolanib 2

Voruciclib 2

VoxtalisibSAR-245409
SAR245409
XL-765
2

XiliertinibHMPL-309
HMPL309
Theliatinib
1

ZandelisibME-401
ME401
3

ZanubrutinibBrukinsaBGB-31112019 4


ZoligratinibDEBIO-1347
DEBIO1347
1

ZorifertinibAZD-3759
AZD3759
2

ZotiraciclibEX45
SB-1317
SB1317
TG-02
TG02
1