KLIFS - the structural kinase database

Searching for structures with analogs of Ribociclib.

Search results (27 entries covering 14 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
EGFR	EGFR	TK	5x2f	C	A	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9527	0.43
EGFR	EGFR	TK	5x2f	A	A	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9540	0.43
EGFR	EGFR	TK	5x2f	D	A	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9544	0.43
EGFR	EGFR	TK	5x2c	B	C	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9570	0.43
EGFR	EGFR	TK	5x2c	B	A	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9569	0.43
EGFR	EGFR	TK	5x2f	B	B	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9541	0.43
CDK2	CDK	CMGC	6oqi	A		5-fluoro-n-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-[(4s)-4-methyl-5,6,7,8-tetrahydro-4h-pyrazolo[1,5-a]azepin-3-yl]pyrimidin-2-amine	Human	12648	0.42
EGFR	EGFR	TK	5x2c	B	B	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9571	0.43
EGFR	EGFR	TK	5x2c	A	C	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9566	0.43
EGFR	EGFR	TK	5x2c	A	B	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9567	0.43
EGFR	EGFR	TK	5x2f	D	B	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9528	0.43
EGFR	EGFR	TK	5x2c	A	A	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9572	0.43
CDK6	CDK	CMGC	3nux	A		4-[5-chloro-3-(1-methylethyl)-1h-pyrazol-4-yl]-n-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amine	Human	2807	0.42
CDK6	CDK	CMGC	2euf	B		6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7(8h)-one	Human	2804	0.63
CDK6	CDK	CMGC	5l2t	A		7-cyclopentyl-n,n-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7h-pyrrolo[2,3-d]pyrimidine-6-carboxamide	Human	6992	1.00
EGFR	EGFR	TK	5x28	A		9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9538	0.43
AURKA (AurA)	Aur	Other	4dhf	B		7-cyclopentyl-2-({1-methyl-5-[(4-methylpiperazin-1-yl)carbonyl]-1h-pyrrol-3-yl}amino)-7h-pyrrolo[2,3-d]pyrimidine-6-carboxamide	Human	1982	0.44
EGFR	EGFR	TK	5x2f	B	A	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9546	0.43
EGFR	EGFR	TK	5x2f	A	B	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9535	0.43
AURKA (AurA)	Aur	Other	4dhf	A		7-cyclopentyl-2-({1-methyl-5-[(4-methylpiperazin-1-yl)carbonyl]-1h-pyrrol-3-yl}amino)-7h-pyrrolo[2,3-d]pyrimidine-6-carboxamide	Human	1964	0.44
EGFR	EGFR	TK	5x2f	C	B	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9542	0.43
CDK6	CDK	CMGC	8i0m	A		2-[(4-azanylcyclohexyl)amino]-7-cyclopentyl-~{n},~{n}-dimethyl-pyrrolo[2,3-d]pyrimidine-6-carboxamide	Human	15164	0.55
CDK9	CDK	CMGC	8i0l	A		2-[(4-azanylcyclohexyl)amino]-7-cyclopentyl-~{n},~{n}-dimethyl-pyrrolo[2,3-d]pyrimidine-6-carboxamide	Human	15170	0.55
CDK6	CDK	CMGC	6oql	A		5-fluoro-n-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-[(4r)-4-methyl-5,6,7,8-tetrahydro-4h-pyrazolo[1,5-a]azepin-3-yl]pyrimidin-2-amine	Human	12647	0.42
CDK6	CDK	CMGC	4tth	B		9-cyclopentyl-n-(5-piperazin-1-ylpyridin-2-yl)pyrido[4,5]pyrrolo[1,2-d]pyrimidin-2-amine	Human	2803	0.58
CDK6	CDK	CMGC	5l2i	A		6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7(8h)-one	Human	6991	0.63
EGFR	EGFR	TK	5x27	A		9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9534	0.43