KLIFS is a kinase database that dissects experimental structures of catalytic kinase domains and the way kinase inhibitors interact with them. The KLIFS structural alignment enables the comparison of all structures and ligands to each other. Moreover, the KLIFS residue numbering scheme capturing the catalytic cleft with 85 residues enables the comparison of the interaction patterns of kinase-inhibitors, for example, to identify crucial interactions determining kinase-inhibitor selectivity.

For more information, go through the frequently asked questions (FAQ) or read our articles in Nucleic Acids Research (2020), Trends in Pharmacological Sciences (2019), and ACS Journal of Medicinal Chemistry (2014).

Statistics
Kinases312
Structures (# PDBs)5851
Monomers12601
Unique ligands3664
KLIFS users in Nov-20211801
Your browser unfortunately does not support an HTML5 canvas. Your browser unfortunately does not support an HTML5 canvas.
News:

Powerful analyses using KLIFS data in KNIME

17-Aug-2021

Modified residues and many more clinical candidates

09-Jul-2021

Granular control over the kinase conformation

03-May-2021
News archive
Latest structures:
PDBKinaseGroupLigand
7dl6DYRK2CMGC[2,7-dimethoxy-9-[[(3R)-pyrrolidin-3-yl]methylsulfanyl]acridin-4-yl]methanol
7ozbFGFR1TK4-[3-(4-piperazin-4-ium-1-ylphenyl)-1H-indazol-6-yl]phenol
7ozdFGFR1TKN-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]benzamide
7ozfFGFR1TKN-[6-(3-ethoxyphenyl)-1H-indazol-3-yl]benzamide
7ozyFGFR2TK4-[3-(4-piperazin-4-ium-1-ylphenyl)-1H-indazol-6-yl]phenol
7pueSGK1AGC6-[4-[[2,3-bis(chloranyl)phenyl]sulfonylamino]phenyl]-~{N}-[(3~{R})-pyrrolidin-3-yl]-2~{H}-pyrazolo[3,4-b]pyridine-4-carboxamide
7pw4SMG1Atypical1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea
7pw5SMG1Atypical1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea
7pw6SMG1Atypical1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea
7pw7SMG1Atypical1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea
7pw8SMG1AtypicalPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
7pw9SMG1AtypicalPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER