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Navigate through KLIFS

Kinase classification
Kinase (HGNC):
Family:
Group:
Organism:
Similarity and (sub)structure
SMILES:
Type of search:
PhysChem properties
Min:Max:
Molecular Weight
LogP
Hydrogen Donors
Hydrogen Acceptors
Heavy Atoms
Rotatable Bonds
Rings
Kinase-ligand interactions
(* = Any interaction, H = H-bond, A = Aromatic, I = Ionic, X = No interaction)
I g.l II III αC
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
αC b.l IV
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
IV V GK hinge linker αD αE
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
αE VI c.l VII VIII x
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
DFG a.l
81
82
83
84
85
Targeted (sub)pockets
Main pocket:
Front cleft
Gate area
Back cleft

Subpockets:
Front pocket I
Front pocket II
Back pocket I A
Back pocket I B
Back pocket II-in
Back pocket IIA-in
Back pocket IIB-in
Back pocket II-out
Back pocket IIB
Back pocket III
Back pocket IV
Back pocket V
Properties
Min:Max:
KLIFS quality score
Release date:
Resolution


Ligand-bound:
Conformation

DFG :
αC-helix :
Salt bridge KIII.17 and EαC.24




Min:Max:
G-rich loop angle :
G-rich loop rotation :
G-rich loop distance :




Activation loop position
Asp. (xDFG.81) rotation
Phe. (xDFG.82) rotation
αC-helix position


Binding pocket sequence
I g.l II III αC
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
αC b.l IV
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
IV V GK hinge linker αD αE
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
αE VI c.l VII VIII x
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
DFG a.l
81
82
83
84
85
Match wild-type sequence instead of structure sequence
Binding pocket waters
I1
I2
I3
I4
I5
I6
I7
I8
I9
I10
I11
O1
O2
O3
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