| FGFR2 | FGFR | TK | 7kie | B | A | n-{4-[(e)-2-{4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}ethenyl]phenyl}prop-2-enamide | Human | 13282 | 0.40 | |
| FGFR2 | FGFR | TK | 7kie | B | B | n-{4-[(e)-2-{4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}ethenyl]phenyl}prop-2-enamide | Human | 13284 | 0.40 | |
| EGFR | EGFR | TK | 5hg5 | A | B | n-{3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}propanamide | Human | 6376 | 0.54 | |
| EGFR | EGFR | TK | 7lg8 | A | | 6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3r)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazine-2-carboxamide | Human | 14120 | 0.40 | |
| EGFR | EGFR | TK | 5hg5 | A | A | n-{3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}propanamide | Human | 6375 | 0.54 | |
| EGFR | EGFR | TK | 3ika | A | B | n-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | Human | 855 | 0.60 | |
| EGFR | EGFR | TK | 5x2k | A | | n-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | Human | 9568 | 0.60 | |
| JAK3 | JakA | TK | 4z16 | C | | n-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide | Human | 6397 | 0.44 | |
| FGFR2 | FGFR | TK | 7kie | A | B | n-{4-[(e)-2-{4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}ethenyl]phenyl}prop-2-enamide | Human | 13286 | 0.40 | |
| FGFR2 | FGFR | TK | 7kie | A | A | n-{4-[(e)-2-{4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}ethenyl]phenyl}prop-2-enamide | Human | 13287 | 0.40 | |
| MAP2K7 | STE7 | STE | 6yg3 | A | A | n-(4-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide | Human | 12689 | 0.60 | |
| EGFR | EGFR | TK | 8hy7 | A | | ~{n}-[3-[[6-fluoranyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]quinazolin-4-yl]amino]phenyl]prop-2-enamide | Human | 14941 | 0.62 | |
| JAK3 | JakA | TK | 4z16 | D | | n-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide | Human | 6394 | 0.44 | |
| EGFR | EGFR | TK | 7zyn | A | B | n-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | Human | 14728 | 0.60 | |
| EGFR | EGFR | TK | 5xdk | A | | n-[3-[[2-[[4-(4-ethanoylpiperazin-1-yl)-2-methoxy-phenyl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide | Human | 9065 | 0.40 | |
| EGFR | EGFR | TK | 7zyn | A | A | n-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | Human | 14727 | 0.60 | |
| EGFR | EGFR | TK | 5y9t | A | | 6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3r)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazine-2-carboxamide | Human | 10053 | 0.40 | |
| JAK3 | JakA | TK | 4z16 | B | | n-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide | Human | 6396 | 0.44 | |
| MAPK3 (Erk1) | MAPK | CMGC | 6ges | B | B | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10924 | 0.40 | |
| MAPK3 (Erk1) | MAPK | CMGC | 6ges | B | A | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10925 | 0.40 | |
| SRC | Src | TK | 6ate | A | | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10920 | 0.40 | |
| EGFR | EGFR | TK | 5gmp | A | B | n-[3-[2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-5-methyl-7-oxidanylidene-pyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide | Human | 8168 | 0.41 | |
| JAK3 | JakA | TK | 4z16 | A | | n-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide | Human | 6395 | 0.44 | |
| MAP3K7 (TAK1) | MLK | TKL | 5j7s | A | | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 7429 | 0.40 | |
| MAP3K7 (TAK1) | MLK | TKL | 5e7r | A | | 2-chloro-n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}acetamide | Human | 7412 | 0.46 | |
| MAP2K7 | STE7 | STE | 6yg3 | A | B | n-(4-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide | Human | 12681 | 0.60 | |
| MAP3K7 (TAK1) | MLK | TKL | 5jh6 | A | | 2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl prop-2-enoate | Human | 7427 | 0.47 | |
| MAP3K7 (TAK1) | MLK | TKL | 5j8i | A | | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | Human | 7428 | 0.59 | |
| MAP3K7 (TAK1) | MLK | TKL | 5jk3 | A | | ~{n}-[2-[5-chloranyl-2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide | Human | 7430 | 0.43 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g54 | A | B | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10937 | 0.40 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g54 | A | A | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10938 | 0.40 | |
| JAK2 | JakA | TK | 4jia | A | B | 5-(4-methoxyphenyl)-n-[4-(4-methylpiperazin-1-yl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3640 | 0.41 | |
| JAK2 | JakA | TK | 4jia | A | A | 5-(4-methoxyphenyl)-n-[4-(4-methylpiperazin-1-yl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3691 | 0.41 | |
| PRKACA (PKACa) | PKA | AGC | 6frx | A | | ~{n}-[3-[(5-chloranyl-2-phenylazanyl-pyrimidin-4-yl)amino]phenyl]prop-2-enamide | Human | 11261 | 0.40 | |
| EGFR | EGFR | TK | 5gmp | A | A | n-[3-[2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-5-methyl-7-oxidanylidene-pyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide | Human | 8167 | 0.41 | |
| EGFR | EGFR | TK | 5xdl | A | | n-[3-[[2-[[4-(4-ethanoylpiperazin-1-yl)-2-methoxy-phenyl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide | Human | 9066 | 0.40 | |
| EGFR | EGFR | TK | 3ika | A | A | n-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | Human | 802 | 0.60 | |
| MAPK3 (Erk1) | MAPK | CMGC | 6ges | A | B | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10926 | 0.40 | |
| MAPK3 (Erk1) | MAPK | CMGC | 6ges | A | A | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10923 | 0.40 | |
| MAP3K7 (TAK1) | MLK | TKL | 5j9l | A | | n-(4-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide | Human | 7426 | 0.60 | |
Match: