KLIFS - the structural kinase database

Searching for structures with analogs of Buparlisib.

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
PDPK1 (PDK1)	PDK1	AGC	3qcs	A	B	6-[2-amino-6-(morpholin-4-yl)pyrimidin-4-yl]-2h-indazol-3-amine	Human	3157	0.40
PDPK1 (PDK1)	PDK1	AGC	3qcs	A	A	6-[2-amino-6-(morpholin-4-yl)pyrimidin-4-yl]-2h-indazol-3-amine	Human	3179	0.40
PIK3CG (p110g)	PIK	Atypical	5oq4	A	B	5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine	Human	9203	0.73
PIK3CG (p110g)	PIK	Atypical	3sd5	A		5-[2,6-di(morpholin-4-yl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine	Human	9243	1.00
PIK3CG (p110g)	PIK	Atypical	5oq4	A	A	5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine	Human	9244	0.73
PIK3CG (p110g)	PIK	Atypical	5jhb	A		[1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol	Human	9238	0.58
PIK3CG (p110g)	PIK	Atypical	5jha	A		[1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)pyrimidin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol	Human	9246	0.76
PIK3CA (p110a)	PIK	Atypical	6oac	A		4-(difluoromethyl)-5-{4-[(3s)-3-methylmorpholin-4-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}pyridin-2-amine	Human	11381	0.44