KLIFS - the structural kinase database

Searching for structures with analogs of -.

Search results (69 entries covering 19 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
VRK1	VRK	CK1	5uvf	A		(7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one	Human	7521	1.00
VRK1	VRK	CK1	6cnx	A	B	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-8-(3-methylbutyl)-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9810	0.82
VRK1	VRK	CK1	6dd4	D	A	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-dipropyl-7,8-dihydropteridin-6(5h)-one	Human	9938	0.73
JAK2-b	JakB	TK	6g3c	A	B	2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-one	Human	10976	0.66
VRK2	VRK	CK1	5uu1	A		(7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one	Human	7499	1.00
RPS6KA3 (RSK2)	RSK	AGC	5d9k	B		(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one	Human	5987	1.00
VRK1	VRK	CK1	6cmm	D	A	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9764	0.69
VRK1	VRK	CK1	6csw	B	B	(7r)-5-butyl-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dimethyl-7,8-dihydropteridin-6(5h)-one	Human	9808	0.63
VRK1	VRK	CK1	6bp0	D	B	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5h)-one	Human	8739	0.75
VRK1	VRK	CK1	6npn	B		(7r)-7-methyl-2-[(3-oxo-2,3-dihydro-1h-indazol-6-yl)amino]-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	11244	0.45
VRK1	VRK	CK1	6cnx	D	A	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-8-(3-methylbutyl)-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9814	0.82
VRK1	VRK	CK1	6cqh	D	A	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9771	0.64
VRK1	VRK	CK1	6vzh	D		(7~{r})-2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7-dimethyl-8-prop-2-ynyl-7~{h}-pteridin-6-one	Human	12055	0.81
VRK1	VRK	CK1	6dd4	D	B	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-dipropyl-7,8-dihydropteridin-6(5h)-one	Human	9934	0.73
RPS6KA3 (RSK2)	RSK	AGC	5d9k	A		(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one	Human	5988	1.00
VRK1	VRK	CK1	6cfm	B	B	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9725	0.81
VRK1	VRK	CK1	6bp0	B	A	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5h)-one	Human	8740	0.75
VRK1	VRK	CK1	6cfm	B	A	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9724	0.81
VRK1	VRK	CK1	6cnx	A	A	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-8-(3-methylbutyl)-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9815	0.82
VRK1	VRK	CK1	6btw	D	A	2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-phenyl-7,8-dihydropteridin-6(5h)-one	Human	9415	0.40
VRK1	VRK	CK1	6cfm	D	A	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9721	0.81
VRK1	VRK	CK1	6bru	B	B	(7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5h)-one	Human	9087	0.75
VRK1	VRK	CK1	6cqh	D	B	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9767	0.64
VRK1	VRK	CK1	6vxu	B		(7r)-8-(cyclopropylmethyl)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	13362	0.60
VRK1	VRK	CK1	6cfm	A	A	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9723	0.81
VRK1	VRK	CK1	6cnx	B	A	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-8-(3-methylbutyl)-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9803	0.82
VRK1	VRK	CK1	5uvf	D		(7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one	Human	7522	1.00
VRK1	VRK	CK1	6cnx	C	B	(7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-8-(3-methylbutyl)-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9804	0.82
VRK1	VRK	CK1	6cmm	B	B	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9761	0.69
VRK1	VRK	CK1	6dd4	B	B	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-dipropyl-7,8-dihydropteridin-6(5h)-one	Human	9933	0.73
VRK1	VRK	CK1	6cmm	B	A	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9766	0.69
VRK1	VRK	CK1	6csw	D	A	(7r)-5-butyl-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dimethyl-7,8-dihydropteridin-6(5h)-one	Human	9817	0.63
VRK1	VRK	CK1	6bp0	D	A	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5h)-one	Human	8745	0.75
VRK1	VRK	CK1	6vzh	B		(7~{r})-2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7-dimethyl-8-prop-2-ynyl-7~{h}-pteridin-6-one	Human	12056	0.81
MELK	CAMKL	CAMK	6vxr	A	B	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	12644	0.69
MELK	CAMKL	CAMK	6vxr	A	A	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	12645	0.69
VRK1	VRK	CK1	6bp0	B	B	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5h)-one	Human	8741	0.75
VRK1	VRK	CK1	6npn	A		(7r)-7-methyl-2-[(3-oxo-2,3-dihydro-1h-indazol-6-yl)amino]-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	11243	0.45
JAK2-b	JakB	TK	5ut1	A	B	(7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one	Human	8049	1.00
VRK1	VRK	CK1	6cqh	A	B	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9768	0.64
VRK1	VRK	CK1	5uvf	B		(7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one	Human	7523	1.00
VRK1	VRK	CK1	6cnx	B	B	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-8-(3-methylbutyl)-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9806	0.82
VRK1	VRK	CK1	6csw	B	A	(7r)-5-butyl-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dimethyl-7,8-dihydropteridin-6(5h)-one	Human	9812	0.63
JAK2-b	JakB	TK	6g3c	B	A	2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-one	Human	10977	0.66
JAK2-b	JakB	TK	6g3c	A	A	2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-one	Human	10978	0.66
JAK2-b	JakB	TK	5ut1	A	A	(7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one	Human	8046	1.00
JAK2-b	JakB	TK	6g3c	B	B	2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-one	Human	10975	0.66
JAK2-b	JakB	TK	5wik	B		(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one	Human	10387	1.00
VRK1	VRK	CK1	6npn	C		(7r)-7-methyl-2-[(3-oxo-2,3-dihydro-1h-indazol-6-yl)amino]-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	11241	0.45
VRK1	VRK	CK1	6csw	D	B	(7r)-5-butyl-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dimethyl-7,8-dihydropteridin-6(5h)-one	Human	9809	0.63
VRK1	VRK	CK1	6bru	B	A	(7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5h)-one	Human	9088	0.75
VRK1	VRK	CK1	6cmm	D	B	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9759	0.69
VRK1	VRK	CK1	6cfm	D	B	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9722	0.81
VRK1	VRK	CK1	6btw	A	B	2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-phenyl-7,8-dihydropteridin-6(5h)-one	Human	9425	0.40
VRK1	VRK	CK1	6cfm	A	B	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9718	0.81
VRK1	VRK	CK1	6bru	D	A	(7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5h)-one	Human	9084	0.75
VRK1	VRK	CK1	6cqh	B	B	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9770	0.64
VRK1	VRK	CK1	6cqh	B	A	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9769	0.64
VRK1	VRK	CK1	6cqh	A	A	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9774	0.64
VRK1	VRK	CK1	6btw	B	A	2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-phenyl-7,8-dihydropteridin-6(5h)-one	Human	9424	0.40
VRK1	VRK	CK1	6btw	A	A	2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-phenyl-7,8-dihydropteridin-6(5h)-one	Human	9418	0.40
VRK1	VRK	CK1	6btw	B	B	2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-phenyl-7,8-dihydropteridin-6(5h)-one	Human	9411	0.40
VRK1	VRK	CK1	6cnx	D	B	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-8-(3-methylbutyl)-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9807	0.82
VRK1	VRK	CK1	6npn	D		(7r)-7-methyl-2-[(3-oxo-2,3-dihydro-1h-indazol-6-yl)amino]-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	11242	0.45
VRK1	VRK	CK1	6btw	D	B	2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-phenyl-7,8-dihydropteridin-6(5h)-one	Human	9420	0.40
VRK1	VRK	CK1	6bru	D	B	(7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5h)-one	Human	9083	0.75
VRK1	VRK	CK1	6cnx	C	A	(7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-8-(3-methylbutyl)-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one	Human	9805	0.82
VRK1	VRK	CK1	6dd4	B	A	(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-dipropyl-7,8-dihydropteridin-6(5h)-one	Human	9937	0.73
VRK1	VRK	CK1	5uvf	C		(7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one	Human	7520	1.00