KLIFS - the structural kinase database

Searching for structures with analogs of -.

Search results (185 entries covering 92 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
IRAK4	IRAK	TKL	4u9a	A		staurosporine	Human	1751	0.73
IRAK4	IRAK	TKL	4u9a	B		staurosporine	Human	1792	0.73
IRAK4	IRAK	TKL	2oic	A		staurosporine	Human	1739	0.73
PDPK1 (PDK1)	PDK1	AGC	1oky	A	A	staurosporine	Human	3164	0.73
STK16 (MPSK1)	NAK	Other	2buj	B		staurosporine	Human	2230	0.73
IRAK4	IRAK	TKL	2oic	D		staurosporine	Human	1755	0.73
EPHB4 (EphB4)	Eph	TK	2yn8	B		staurosporine	Human	349	0.73
PRKAA2 (AMPKa2)	CAMKL	CAMK	6b1u	C	A	staurosporine	Human	9847	0.73
PIK3CG (p110g)	PIK	Atypical	1e8z	A		staurosporine	Human	9228	0.73
MAP3K5	STE11	STE	2clq	A	B	staurosporine	Human	4736	0.73
EGFR	EGFR	TK	2itq	A	A	1,2,3,4-tetrahydrogen staurosporine	Human	813	0.57
PRKAA1 (AMPKa1)	CAMKL	CAMK	4rew	A		staurosporine	Human	124	0.73
PRKAA1 (AMPKa1)	CAMKL	CAMK	6c9h	A		staurosporine	Human	10714	0.73
PRKAA1 (AMPKa1)	CAMKL	CAMK	4rer	A		staurosporine	Human	121	0.73
PRKAA1 (AMPKa1)	CAMKL	CAMK	6c9j	A		staurosporine	Human	10717	0.73
Prkaa1 (AMPKa1)	CAMKL	CAMK	5ufu	A		staurosporine	Mouse	7590	0.73
EGFR	EGFR	TK	2itw	A	A	1,2,3,4-tetrahydrogen staurosporine	Human	817	0.57
CDK2	CDK	CMGC	4ez7	A		staurosporine	Human	4240	0.73
ERN1 (IRE1)	IRE	Other	4yzc	A	A	staurosporine	Human	6235	0.73
IRAK4	IRAK	TKL	2nry	C	A	staurosporine	Human	1779	0.73
TGFBR1 (TGFbR1)	STKR	TKL	5e8w	A	A	staurosporine	Human	6611	0.73
EPHB4 (EphB4)	Eph	TK	2yn8	A		staurosporine	Human	352	0.73
EPHB4 (EphB4)	Eph	TK	3zew	B	B	staurosporine	Human	357	0.73
PKN1	PKN	AGC	4otg	A	A	lestaurtinib	Human	548	0.40
ERN1 (IRE1)	IRE	Other	4yzc	A	B	staurosporine	Human	6232	0.73
CHEK1 (CHK1)	CAMKL	CAMK	7ako	A	B	staurosporine	Human	13495	0.73
CDK2	CDK	CMGC	7nvq	A		staurosporine	Human	13627	0.73
STK24 (MST3)	STE20	STE	3ckx	A		staurosporine	Human	5599	0.73
STK24 (MST3)	STE20	STE	4qmy	A		staurosporine	Human	5592	0.73
RPS6KA1 (RSK3)	RSK	AGC	2z7r	A		staurosporine	Human	2777	0.73
PRKAA2 (AMPKa2)	CAMKL	CAMK	7myj	A		(5s,6r,7r,9r,13cr,14r,16as)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,14,15,16,16a-octahydro-5h,13ch-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-ol	Human	14273	0.57
MAPKAPK2	MAPKAPK	CAMK	1nxk	A		staurosporine	Human	1342	0.73
CDK2	CDK	CMGC	1pkd	A		7-hydroxystaurosporine	Human	4170	1.00
PRKAA2 (AMPKa2)	CAMKL	CAMK	4cff	C		staurosporine	Human	190	0.73
PRKAA2 (AMPKa2)	CAMKL	CAMK	5iso	A		staurosporine	Human	7981	0.73
PRKAA2 (AMPKa2)	CAMKL	CAMK	6b1u	A	A	staurosporine	Human	9848	0.73
PRKAA2 (AMPKa2)	CAMKL	CAMK	5ezv	C	A	staurosporine	Human	6430	0.73
EGFR	EGFR	TK	2itq	A	B	1,2,3,4-tetrahydrogen staurosporine	Human	846	0.57
PRKAA2 (AMPKa2)	CAMKL	CAMK	6b1u	C	B	staurosporine	Human	9850	0.73
PRKAA2 (AMPKa2)	CAMKL	CAMK	5iso	C		staurosporine	Human	7980	0.73
PRKAA2 (AMPKa2)	CAMKL	CAMK	4zhx	C	B	(5s,6r,7r,9r,13cr,14r,16as)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,14,15,16,16a-octahydro-5h,13ch-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-ol	Human	6423	0.57
TTK	TTK	Other	3hmo	A		staurosporine	Human	4707	0.73
PIM1	PIM	CAMK	1yhs	A		staurosporine	Human	2444	0.73
FES	Fer	TK	3cd3	A	A	staurosporine	Human	2814	0.73
FES	Fer	TK	3cbl	A	B	staurosporine	Human	2811	0.73
IRAK4	IRAK	TKL	2nry	A	A	staurosporine	Human	1753	0.73
FES	Fer	TK	3bkb	A	B	staurosporine	Human	2813	0.73
FES	Fer	TK	3bkb	A	A	staurosporine	Human	2810	0.73
ERN1 (IRE1)	IRE	Other	4yzc	B	A	staurosporine	Human	6227	0.73
PRKAA2 (AMPKa2)	CAMKL	CAMK	4cfe	C		staurosporine	Human	192	0.73
FES	Fer	TK	3cd3	A	B	staurosporine	Human	2815	0.73
PRKAA2 (AMPKa2)	CAMKL	CAMK	4cff	A		staurosporine	Human	191	0.73
EGFR	EGFR	TK	2itw	A	B	1,2,3,4-tetrahydrogen staurosporine	Human	914	0.57
EPHB4 (EphB4)	Eph	TK	3zew	B	A	staurosporine	Human	351	0.73
CDK2	CDK	CMGC	1pkd	C		7-hydroxystaurosporine	Human	3973	1.00
CDK2	CDK	CMGC	4erw	A		staurosporine	Human	4370	0.73
ZAP70	Syk	TK	1u59	A	B	staurosporine	Human	2733	0.73
LYN	Src	TK	3a4o	X		staurosporine	Human	1812	0.73
IRAK4	IRAK	TKL	4u97	A		staurosporine	Human	1754	0.73
MASTL	MAST	AGC	5loh	B	B	staurosporine	Human	7087	0.73
MASTL	MAST	AGC	5loh	A	B	staurosporine	Human	7085	0.73
MASTL	MAST	AGC	5loh	A	A	staurosporine	Human	7086	0.73
JAK3	JakA	TK	1yvj	A	A	1,2,3,4-tetrahydrogen-staurosporine	Human	460	0.62
MASTL	MAST	AGC	5loh	B	A	staurosporine	Human	7088	0.73
FES	Fer	TK	3cbl	A	A	staurosporine	Human	2808	0.73
JAK3	JakA	TK	1yvj	A	B	1,2,3,4-tetrahydrogen-staurosporine	Human	451	0.62
GSK3B	GSK	CMGC	1q3d	A		staurosporine	Human	705	0.73
TGFBR1 (TGFbR1)	STKR	TKL	5e8x	A	B	staurosporine	Human	6617	0.73
STK32A (YANK1)	YANK	AGC	4fr4	B	A	staurosporine	Human	4692	0.73
IRAK4	IRAK	TKL	4u97	B		staurosporine	Human	1742	0.73
IRAK4	IRAK	TKL	2oic	B		staurosporine	Human	1752	0.73
LIMK1	LISK	TKL	3s95	B	A	staurosporine	Human	1245	0.73
ITK	Tec	TK	1sm2	A		staurosporine	Human	74	0.73
IRAK4	IRAK	TKL	2nry	D	B	staurosporine	Human	1746	0.73
IRAK4	IRAK	TKL	2nry	C	B	staurosporine	Human	1750	0.73
IRAK4	IRAK	TKL	2nry	A	B	staurosporine	Human	1777	0.73
IRAK4	IRAK	TKL	2oic	C		staurosporine	Human	1734	0.73
PKN1	PKN	AGC	4otg	A	B	lestaurtinib	Human	549	0.40
STK32A (YANK1)	YANK	AGC	4fr4	C	B	staurosporine	Human	4694	0.73
EPHB4 (EphB4)	Eph	TK	3zew	A	A	staurosporine	Human	373	0.73
STK32A (YANK1)	YANK	AGC	4fr4	D	A	staurosporine	Human	4688	0.73
STK32A (YANK1)	YANK	AGC	4fr4	F	A	staurosporine	Human	4691	0.73
MAPKAPK2	MAPKAPK	CAMK	1nxk	D		staurosporine	Human	1334	0.73
MAPKAPK2	MAPKAPK	CAMK	1nxk	C		staurosporine	Human	1312	0.73
MAPKAPK2	MAPKAPK	CAMK	2pzy	C		staurosporine	Human	1279	0.73
MAPKAPK2	MAPKAPK	CAMK	1nxk	B		staurosporine	Human	1292	0.73
FES	Fer	TK	3bkb	A	C	staurosporine	Human	2812	0.73
IKBKB (IKKb)	IKK	Other	4kik	B	B	k-252a	Human	293	0.47
IKBKB (IKKb)	IKK	Other	4kik	A	A	k-252a	Human	290	0.47
IKBKB (IKKb)	IKK	Other	4kik	B	A	k-252a	Human	295	0.47
IKBKB (IKKb)	IKK	Other	4kik	A	B	k-252a	Human	288	0.47
EPHB4 (EphB4)	Eph	TK	3zew	A	B	staurosporine	Human	377	0.73
ERN1 (IRE1)	IRE	Other	4yzc	B	B	staurosporine	Human	6231	0.73
STK32A (YANK1)	YANK	AGC	4fr4	E	A	staurosporine	Human	4689	0.73
STK32A (YANK1)	YANK	AGC	4fr4	B	B	staurosporine	Human	4695	0.73
STK32A (YANK1)	YANK	AGC	4fr4	F	B	staurosporine	Human	4686	0.73
PRKAA1 (AMPKa1)	CAMKL	CAMK	6c9g	A		staurosporine	Human	10715	0.73
RIPK2	RIPK	TKL	5ng2	B	B	staurosporine	Human	8052	0.73
RIPK2	RIPK	TKL	5ng2	A	B	staurosporine	Human	8056	0.73
RIPK2	RIPK	TKL	5ng2	B	A	staurosporine	Human	8053	0.73
RIPK2	RIPK	TKL	5ng2	A	A	staurosporine	Human	8050	0.73
MKNK2 (MNK2)	MAPKAPK	CAMK	2hw7	A		staurosporine	Human	764	0.73
ABL1	Abl	TK	2hz4	B		1,2,3,4-tetrahydrogen-staurosporine	Human	1058	0.62
JAK2	JakA	TK	8bpw	A	B	lestaurtinib	Human	15039	0.40
JAK2	JakA	TK	8bpw	A	A	lestaurtinib	Human	15044	0.40
SYK	Syk	TK	1xbc	A	B	staurosporine	Human	1207	0.73
SYK	Syk	TK	1xbc	A	A	staurosporine	Human	1165	0.73
DYRK1A	DYRK	CMGC	4nct	A		pkc412	Human	3794	0.54
DYRK1A	DYRK	CMGC	4nct	C		pkc412	Human	3779	0.54
DYRK1A	DYRK	CMGC	4nct	B		pkc412	Human	3743	0.54
DYRK1A	DYRK	CMGC	4nct	D		pkc412	Human	3751	0.54
STK32A (YANK1)	YANK	AGC	4fr4	A	A	staurosporine	Human	4693	0.73
STK32A (YANK1)	YANK	AGC	4fr4	E	B	staurosporine	Human	4685	0.73
STK32A (YANK1)	YANK	AGC	4fr4	A	B	staurosporine	Human	4690	0.73
STK32A (YANK1)	YANK	AGC	4fr4	C	A	staurosporine	Human	4684	0.73
STK32A (YANK1)	YANK	AGC	4fr4	D	B	staurosporine	Human	4687	0.73
CHEK1 (CHK1)	CAMKL	CAMK	1nvs	A		rel-(9r,12s)-9,10,11,12-tetrahydro-9,12-epoxy-1h-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2h)-dione	Human	1591	0.42
CHEK1 (CHK1)	CAMKL	CAMK	1nvr	A		staurosporine	Human	1585	0.73
CHEK1 (CHK1)	CAMKL	CAMK	7ako	A	A	staurosporine	Human	13490	0.73
CHEK1 (CHK1)	CAMKL	CAMK	7ako	B	A	staurosporine	Human	13492	0.73
CHEK1 (CHK1)	CAMKL	CAMK	5oor	A		staurosporine	Human	8603	0.73
CHEK1 (CHK1)	CAMKL	CAMK	7ako	B	B	staurosporine	Human	13496	0.73
CHEK1 (CHK1)	CAMKL	CAMK	1nvq	A		7-hydroxystaurosporine	Human	1642	1.00
PAK1	STE20	STE	2hy8	1		(5s,6r,7r,9r)-12-hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9-tetrahydro-5h,14h-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one	Human	172	0.66
MELK	CAMKL	CAMK	5m5a	A	A	k-252a	Human	8735	0.47
MELK	CAMKL	CAMK	5m5a	A	B	k-252a	Human	8733	0.47
STK16 (MPSK1)	NAK	Other	2buj	A		staurosporine	Human	2229	0.73
GSK3B	GSK	CMGC	1q3d	B		staurosporine	Human	752	0.73
CSK	Csk	TK	3d7t	A		staurosporine	Human	2941	0.73
CSK	Csk	TK	1byg	A		staurosporine	Human	2943	0.73
LCK	Src	TK	1qpd	A		staurosporine	Human	2267	0.73
LCK	Src	TK	1qpj	A		staurosporine	Human	2283	0.73
MAP3K5	STE11	STE	4bf2	A		staurosporine	Human	4743	0.73
MAP3K5	STE11	STE	2clq	A	A	staurosporine	Human	4740	0.73
MAP3K5	STE11	STE	2clq	B	A	staurosporine	Human	4755	0.73
MAP3K5	STE11	STE	4bf2	B		staurosporine	Human	4745	0.73
MAP3K5	STE11	STE	2clq	B	B	staurosporine	Human	4732	0.73
DAPK1	DAPK	CAMK	1wvy	A		staurosporine	Human	5661	0.73
EGFR	EGFR	TK	2itu	A	B	1,2,3,4-tetrahydrogen staurosporine	Human	859	0.57
EGFR	EGFR	TK	2itu	A	A	1,2,3,4-tetrahydrogen staurosporine	Human	779	0.57
CDK2	CDK	CMGC	1aq1	A		staurosporine	Human	4267	0.73
IRAK4	IRAK	TKL	2nry	B	B	staurosporine	Human	1772	0.73
IRAK4	IRAK	TKL	2nry	B	A	staurosporine	Human	1758	0.73
IRAK4	IRAK	TKL	2nry	D	A	staurosporine	Human	1789	0.73
ALK	ALK	TK	3lcs	A	A	staurosporine	Human	5381	0.73
ALK	ALK	TK	3lcs	A	B	staurosporine	Human	5376	0.73
PDPK1 (PDK1)	PDK1	AGC	1okz	A		7-hydroxystaurosporine	Human	3209	1.00
PDPK1 (PDK1)	PDK1	AGC	1oky	A	B	staurosporine	Human	3195	0.73
LIMK1	LISK	TKL	3s95	A	A	staurosporine	Human	1246	0.73
LIMK1	LISK	TKL	3s95	A	B	staurosporine	Human	1248	0.73
LIMK1	LISK	TKL	3s95	B	B	staurosporine	Human	1247	0.73
PRKCQ (PKCt)	PKC	AGC	1xjd	A		staurosporine	Human	5357	0.73
ITK	Tec	TK	1snu	A		staurosporine	Human	82	0.73
ITK	Tec	TK	1snu	B		staurosporine	Human	33	0.73
ITK	Tec	TK	1sm2	B		staurosporine	Human	73	0.73
FYN	Src	TK	2dq7	X		staurosporine	Human	1941	0.73
TGFBR1 (TGFbR1)	STKR	TKL	5e8w	A	B	staurosporine	Human	6614	0.73
TGFBR1 (TGFbR1)	STKR	TKL	5e8x	A	A	staurosporine	Human	6615	0.73
RPS6KB1 (p70S6K)	RSK	AGC	3a61	A		staurosporine	Human	1846	0.73
RPS6KB1 (p70S6K)	RSK	AGC	3a62	A		staurosporine	Human	1867	0.73
RPS6KB1 (p70S6K)	RSK	AGC	3a60	B		staurosporine	Human	1856	0.73
RPS6KB1 (p70S6K)	RSK	AGC	3a60	A		staurosporine	Human	1852	0.73
RPS6KB1 (p70S6K)	RSK	AGC	4rlo	B		staurosporine	Human	7220	0.73
PAK4	STE20	STE	5ved	A		staurosporine	Human	8570	0.73
PRKAA1 (AMPKa1)	CAMKL	CAMK	6c9f	A		staurosporine	Human	10716	0.73
MET	Met	TK	1r0p	A		k-252a	Human	2991	0.47
MAP2K1	STE7	STE	3eqf	A		k-252a	Human	3317	0.47
MAP2K6	STE7	STE	3fme	A		staurosporine	Human	1231	0.73
PRKAA2 (AMPKa2)	CAMKL	CAMK	4zhx	A	A	(5s,6r,7r,9r,13cr,14r,16as)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,14,15,16,16a-octahydro-5h,13ch-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-ol	Human	6425	0.57
PRKAA2 (AMPKa2)	CAMKL	CAMK	5ezv	A	B	staurosporine	Human	6428	0.73
PRKAA2 (AMPKa2)	CAMKL	CAMK	6b1u	A	B	staurosporine	Human	9849	0.73
PRKAA2 (AMPKa2)	CAMKL	CAMK	4cfe	A		staurosporine	Human	195	0.73
PRKAA2 (AMPKa2)	CAMKL	CAMK	4zhx	C	A	(5s,6r,7r,9r,13cr,14r,16as)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,14,15,16,16a-octahydro-5h,13ch-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-ol	Human	6427	0.57
PRKAA2 (AMPKa2)	CAMKL	CAMK	5ezv	C	B	staurosporine	Human	6426	0.73
PRKAA2 (AMPKa2)	CAMKL	CAMK	5ezv	A	A	staurosporine	Human	6424	0.73
PRKAA2 (AMPKa2)	CAMKL	CAMK	6b2e	A		staurosporine	Human	9851	0.73
PRKAA2 (AMPKa2)	CAMKL	CAMK	4zhx	A	B	(5s,6r,7r,9r,13cr,14r,16as)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,14,15,16,16a-octahydro-5h,13ch-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-ol	Human	6429	0.57
AAK1	NAK	Other	4wsq	B	B	k-252a	Human	3835	0.47
AAK1	NAK	Other	4wsq	A	A	k-252a	Human	3834	0.47
AAK1	NAK	Other	4wsq	B	A	k-252a	Human	3833	0.47
AAK1	NAK	Other	4wsq	A	B	k-252a	Human	3836	0.47
TGFBR2 (TGFbR2)	STKR	TKL	5e8y	A		staurosporine	Human	6627	0.73
Ripk4 (ANKRD3)	RIPK	TKL	5wnl	A		staurosporine	Mouse	9891	0.73
Ripk4 (ANKRD3)	RIPK	TKL	5wnj	A		lestaurtinib	Mouse	9893	0.40
ZAP70	Syk	TK	1u59	A	A	staurosporine	Human	2734	0.73