Searching for structures with analogs of Filgotinib.
Search results (8 entries covering 3 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | Similarity (MFP) | File |
|---|---|---|---|---|---|---|---|---|---|---|---|
| JAK2-b | JakB | TK | 5ut5 | A | A | n-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide | Human | 8042 | 1.00 | ||
| JAK2-b | JakB | TK | 5ut5 | A | B | n-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide | Human | 8037 | 1.00 | ||
| JAK2 | JakA | TK | 4p7e | B | n-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide | Human | 3701 | 1.00 | |||
| JAK1 | JakA | TK | 6rsc | A | B | 1-[4-(cyanomethyl)-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12468 | 0.41 | ||
| JAK1 | JakA | TK | 6rsc | B | B | 1-[4-(cyanomethyl)-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12469 | 0.41 | ||
| JAK1 | JakA | TK | 6rsc | A | A | 1-[4-(cyanomethyl)-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12477 | 0.41 | ||
| JAK2 | JakA | TK | 4p7e | A | n-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide | Human | 3682 | 1.00 | |||
| JAK1 | JakA | TK | 6rsc | B | A | 1-[4-(cyanomethyl)-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12474 | 0.41 |
Filgotinib
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