| FGR | Src | TK | 7uy0 | A | C | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 14564 | 0.45 | |
| BTK | Tec | TK | 4yhf | A | A | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2916 | 0.70 | |
| BTK | Tec | TK | 7l5p | A | A | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14269 | 0.57 | |
| HCK | Src | TK | 3vs3 | B | | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2665 | 0.45 | |
| EGFR | EGFR | TK | 5gty | D | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8368 | 0.62 | |
| EGFR | EGFR | TK | 5j9y | A | A | (r)-1-(3-(4-amino-3-(naphthalen-1-yl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one | Human | 6946 | 0.68 | |
| PIK3CG (p110g) | PIK | Atypical | 3ene | A | | 1-methyl-3-naphthalen-2-yl-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 9188 | 0.40 | |
| EGFR | EGFR | TK | 5gty | C | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8366 | 0.62 | |
| EGFR | EGFR | TK | 5gnk | A | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(1-methylimidazol-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 7525 | 0.61 | |
| EGFR | EGFR | TK | 5yu9 | D | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9431 | 1.00 | |
| BTK | Tec | TK | 7l5o | A | B | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14271 | 0.57 | |
| EGFR | EGFR | TK | 5gty | D | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8356 | 0.62 | |
| WNK3 (Wnk3) | WNK | Other | 5o2b | B | A | 1-cyclopentyl-3-(1h-pyrrolo[2,3-b]pyridin-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 8154 | 0.41 | |
| EGFR | EGFR | TK | 5gty | E | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8359 | 0.62 | |
| BTK | Tec | TK | 7l5o | A | C | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14268 | 0.57 | |
| BTK | Tec | TK | 7l5p | A | B | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14270 | 0.57 | |
| EGFR | EGFR | TK | 5yu9 | A | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9430 | 1.00 | |
| MAP2K7 | STE7 | STE | 6qhr | A | | 1-[(3~{r})-3-[4-azanyl-3-(1~{h}-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 11082 | 0.51 | |
| BTK | Tec | TK | 6omu | A | A | 1-[4-({[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino}methyl)piperidin-1-yl]prop-2-en-1-one | Human | 11529 | 0.52 | |
| EGFR | EGFR | TK | 5yu9 | C | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9432 | 1.00 | |
| STK24 (MST3) | STE20 | STE | 4qmw | A | A | 1-cyclopentyl-3-(1h-pyrrolo[2,3-b]pyridin-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 5577 | 0.41 | |
| BTK | Tec | TK | 5p9i | A | C | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 7638 | 1.00 | |
| MAP2K7 | STE7 | STE | 7ovj | A | B | 1-[(3~{r})-3-[4-azanyl-3-[1-[2,2-bis(fluoranyl)-2-phenyl-ethyl]-1,2,3-triazol-4-yl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 14299 | 0.49 | |
| FGR | Src | TK | 7uy0 | B | A | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 14566 | 0.45 | |
| MAP2K7 | STE7 | STE | 6qg7 | A | | (r)-1-(3-(4-amino-3-(naphthalen-1-yl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one | Human | 11083 | 0.68 | |
| MAP2K7 | STE7 | STE | 6qft | A | | 1-[(3~{r})-3-(4-azanyl-3-iodanyl-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]propan-1-one | Human | 11085 | 0.51 | |
| HCK | Src | TK | 5zj6 | A | | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 9987 | 0.45 | |
| EGFR | EGFR | TK | 5yu9 | C | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9427 | 1.00 | |
| MAP2K7 | STE7 | STE | 7ovk | A | | 1-[(3~{r})-3-[4-azanyl-3-[1-(5-bromanyl-2-oxidanyl-phenyl)-1,2,3-triazol-4-yl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 14298 | 0.44 | |
| EGFR | EGFR | TK | 5gty | H | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8362 | 0.62 | |
| EGFR | EGFR | TK | 5gty | A | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8363 | 0.62 | |
| EGFR | EGFR | TK | 5gty | E | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8353 | 0.62 | |
| BTK | Tec | TK | 5p9m | A | A | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Human | 7634 | 0.50 | |
| BTK | Tec | TK | 6omu | A | B | 1-[4-({[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino}methyl)piperidin-1-yl]prop-2-en-1-one | Human | 11530 | 0.52 | |
| EGFR | EGFR | TK | 5gty | B | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8367 | 0.62 | |
| EGFR | EGFR | TK | 5gty | G | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8369 | 0.62 | |
| EGFR | EGFR | TK | 5yu9 | D | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9429 | 1.00 | |
| STK24 (MST3) | STE20 | STE | 4qmw | A | B | 1-cyclopentyl-3-(1h-pyrrolo[2,3-b]pyridin-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 5582 | 0.41 | |
| EGFR | EGFR | TK | 5yu9 | B | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9433 | 1.00 | |
| Btk (BTK) | Tec | TK | 8ff0 | A | | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Mouse | 14834 | 0.50 | |
| EGFR | EGFR | TK | 5gty | A | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8352 | 0.62 | |
| EGFR | EGFR | TK | 5gty | H | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8357 | 0.62 | |
| FGR | Src | TK | 7uy0 | B | B | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 14565 | 0.45 | |
| FGR | Src | TK | 7uy0 | A | B | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 14563 | 0.45 | |
| MAP2K7 | STE7 | STE | 6yg2 | A | B | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 12686 | 0.80 | |
| EGFR | EGFR | TK | 5gty | F | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8364 | 0.62 | |
| HCK | Src | TK | 2c0t | B | A | n-(4-{4-amino-1-[1-(tetrahydro-2h-pyran-4-yl)piperidin-4-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2642 | 0.42 | |
| EGFR | EGFR | TK | 5gty | G | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8355 | 0.62 | |
| EGFR | EGFR | TK | 5yu9 | B | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9434 | 1.00 | |
| HCK | Src | TK | 5h0g | A | | (2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{n},4-dimethyl-pentanamide | Human | 8536 | 0.44 | |
| WNK3 (Wnk3) | WNK | Other | 5o2b | A | B | 1-cyclopentyl-3-(1h-pyrrolo[2,3-b]pyridin-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 8153 | 0.41 | |
| WNK3 (Wnk3) | WNK | Other | 5o2b | B | B | 1-cyclopentyl-3-(1h-pyrrolo[2,3-b]pyridin-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 8161 | 0.41 | |
| WNK3 (Wnk3) | WNK | Other | 5o2b | A | A | 1-cyclopentyl-3-(1h-pyrrolo[2,3-b]pyridin-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 8163 | 0.41 | |
| EGFR | EGFR | TK | 5gty | F | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8354 | 0.62 | |
| EGFR | EGFR | TK | 5gnk | A | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(1-methylimidazol-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 7524 | 0.61 | |
| FGR | Src | TK | 7uy0 | B | C | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 14562 | 0.45 | |
| FGR | Src | TK | 7uy0 | A | A | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 14568 | 0.45 | |
| MAP2K7 | STE7 | STE | 6yg2 | A | A | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 12678 | 0.80 | |
| MAP2K7 | STE7 | STE | 6qg4 | A | | 1-[(3~{r})-3-[4-azanyl-3-(4-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 11084 | 0.61 | |
| MAP2K7 | STE7 | STE | 7ovi | A | | 1-[(3~{r})-3-[4-azanyl-3-[1-(2-phenylethyl)-1,2,3-triazol-4-yl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 14301 | 0.52 | |
| MAP2K7 | STE7 | STE | 6ib0 | A | | 1-[(3~{r})-3-(4-azanyl-3-ethynyl-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]prop-2-en-1-one | Human | 10922 | 0.62 | |
| MAP2K7 | STE7 | STE | 7ovj | A | A | 1-[(3~{r})-3-[4-azanyl-3-[1-[2,2-bis(fluoranyl)-2-phenyl-ethyl]-1,2,3-triazol-4-yl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 14306 | 0.49 | |
| MAP2K7 | STE7 | STE | 6qho | A | | 1-[(3~{r})-3-(4-azanylpyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]propan-1-one | Human | 11079 | 0.43 | |
| MAP2K7 | STE7 | STE | 6ib2 | A | | 1-[(3~{r})-3-[4-azanyl-3-[1-(4-ethanoylphenyl)-1,2,3-triazol-4-yl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 10921 | 0.46 | |
| HCK | Src | TK | 2c0i | A | A | n-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)-trans-cyclohexyl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2662 | 0.42 | |
| HCK | Src | TK | 3vs0 | A | | n-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide | Human | 2633 | 0.40 | |
| HCK | Src | TK | 3vs1 | B | | 1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea | Human | 2636 | 0.42 | |
| HCK | Src | TK | 2c0o | B | A | n-(4-{1-[4-(4-acetylpiperazin-1-yl)-trans-cyclohexyl]-4-amino-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2663 | 0.43 | |
| HCK | Src | TK | 2c0i | B | A | n-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)-trans-cyclohexyl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2650 | 0.42 | |
| HCK | Src | TK | 3vs4 | A | | 5-(4-phenoxyphenyl)-7-(tetrahydro-2h-pyran-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2654 | 0.46 | |
| HCK | Src | TK | 3vs0 | B | | n-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide | Human | 2644 | 0.40 | |
| HCK | Src | TK | 2c0i | B | B | n-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)-trans-cyclohexyl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2640 | 0.42 | |
| HCK | Src | TK | 3vs2 | B | | 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2632 | 0.45 | |
| HCK | Src | TK | 3vs5 | B | | 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2669 | 0.47 | |
| HCK | Src | TK | 3vs2 | A | | 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2651 | 0.45 | |
| HCK | Src | TK | 2c0t | A | B | n-(4-{4-amino-1-[1-(tetrahydro-2h-pyran-4-yl)piperidin-4-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2667 | 0.42 | |
| HCK | Src | TK | 3vs7 | A | | 1-cyclopentyl-3-(1h-pyrrolo[2,3-b]pyridin-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 2659 | 0.41 | |
| HCK | Src | TK | 3vs5 | A | | 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2645 | 0.47 | |
| HCK | Src | TK | 3vs7 | B | | 1-cyclopentyl-3-(1h-pyrrolo[2,3-b]pyridin-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 2648 | 0.41 | |
| HCK | Src | TK | 4lue | A | | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2655 | 0.45 | |
| HCK | Src | TK | 2c0t | A | A | n-(4-{4-amino-1-[1-(tetrahydro-2h-pyran-4-yl)piperidin-4-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2653 | 0.42 | |
| HCK | Src | TK | 2c0o | A | A | n-(4-{1-[4-(4-acetylpiperazin-1-yl)-trans-cyclohexyl]-4-amino-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2666 | 0.43 | |
| HCK | Src | TK | 4lue | B | | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2668 | 0.45 | |
| HCK | Src | TK | 5h09 | A | | ethyl (2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanoate | Human | 8537 | 0.43 | |
| HCK | Src | TK | 5h0h | A | | (2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{n},~{n},4-trimethyl-pentanamide | Human | 8539 | 0.44 | |
| HCK | Src | TK | 2c0t | B | B | n-(4-{4-amino-1-[1-(tetrahydro-2h-pyran-4-yl)piperidin-4-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2634 | 0.42 | |
| HCK | Src | TK | 2c0o | A | B | n-(4-{1-[4-(4-acetylpiperazin-1-yl)-trans-cyclohexyl]-4-amino-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2652 | 0.43 | |
| HCK | Src | TK | 3vs3 | A | | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2643 | 0.45 | |
| HCK | Src | TK | 3vry | A | | 4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | Human | 2647 | 0.51 | |
| HCK | Src | TK | 2c0i | A | B | n-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)-trans-cyclohexyl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2649 | 0.42 | |
| HCK | Src | TK | 5h0e | A | | (2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanamide | Human | 8538 | 0.44 | |
| HCK | Src | TK | 3vry | B | | 4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | Human | 2646 | 0.51 | |
| HCK | Src | TK | 2c0o | B | B | n-(4-{1-[4-(4-acetylpiperazin-1-yl)-trans-cyclohexyl]-4-amino-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2657 | 0.43 | |
| HCK | Src | TK | 5h0b | A | | (2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]azaniumyl]-4-methyl-pentanoate | Human | 8567 | 0.43 | |
| HCK | Src | TK | 5zj6 | B | | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 9988 | 0.45 | |
| HCK | Src | TK | 3vs4 | B | | 5-(4-phenoxyphenyl)-7-(tetrahydro-2h-pyran-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2638 | 0.46 | |
| FGFR1 | FGFR | TK | 6mzw | B | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11165 | 0.51 | |
| FGFR1 | FGFR | TK | 6mzq | A | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 10860 | 0.51 | |
| FGFR1 | FGFR | TK | 6mzq | B | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11161 | 0.51 | |
| FGFR1 | FGFR | TK | 6mzw | A | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11162 | 0.51 | |
| FGFR1 | FGFR | TK | 6mzq | B | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11171 | 0.51 | |
| FGFR1 | FGFR | TK | 6mzw | A | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11157 | 0.51 | |
| FGFR1 | FGFR | TK | 6mzq | A | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11156 | 0.51 | |
| FGFR1 | FGFR | TK | 6mzw | B | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 10857 | 0.51 | |
| EGFR | EGFR | TK | 5j9z | A | | (r)-1-(3-(4-amino-3-(1-methyl-1h-indol-3-yl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one | Human | 6947 | 0.65 | |
| EGFR | EGFR | TK | 5gty | B | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8360 | 0.62 | |
| EGFR | EGFR | TK | 5yu9 | A | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9428 | 1.00 | |
| EGFR | EGFR | TK | 5j9y | A | B | (r)-1-(3-(4-amino-3-(naphthalen-1-yl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one | Human | 6945 | 0.68 | |
| EGFR | EGFR | TK | 5gty | C | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8358 | 0.62 | |
| ITK | Tec | TK | 4hcv | A | | 3-{4-amino-1-[(3s)-1-propanoylpiperidin-3-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-n-[4-(propan-2-yl)phenyl]benzamide | Human | 32 | 0.50 | |
| ITK | Tec | TK | 4hct | A | | 3-{1-[(3r)-1-acryloylpiperidin-3-yl]-4-amino-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-n-(3-tert-butylphenyl)benzamide | Human | 44 | 0.60 | |
| ITK | Tec | TK | 4hcu | A | | 3-{4-amino-1-[(3r)-1-propanoylpiperidin-3-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-n-[4-(propan-2-yl)phenyl]benzamide | Human | 81 | 0.50 | |
| BTK | Tec | TK | 5p9j | A | B | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 7628 | 0.80 | |
| BTK | Tec | TK | 5p9i | A | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 7627 | 1.00 | |
| BTK | Tec | TK | 3gen | A | B | 4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | Human | 2900 | 0.51 | |
| BTK | Tec | TK | 4yhf | B | B | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2912 | 0.70 | |
| BTK | Tec | TK | 5p9m | A | B | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Human | 7639 | 0.50 | |
| BTK | Tec | TK | 3gen | A | A | 4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | Human | 2928 | 0.51 | |
| BTK | Tec | TK | 4yhf | B | A | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2897 | 0.70 | |
| BTK | Tec | TK | 5p9j | A | C | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 7640 | 0.80 | |
| BTK | Tec | TK | 5p9j | A | A | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 7637 | 0.80 | |
| BTK | Tec | TK | 5p9i | A | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 7642 | 1.00 | |
| BTK | Tec | TK | 5p9m | A | C | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Human | 7641 | 0.50 | |
| BTK | Tec | TK | 4yhf | A | B | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2902 | 0.70 | |
| BTK | Tec | TK | 7l5o | A | A | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14272 | 0.57 | |
| HCK | Src | TK | 3vs1 | A | | 1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea | Human | 2635 | 0.42 | |
Match: