| EGFR | EGFR | TK | 4i23 | A | | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 870 | 0.60 | |
| EPHA2 (EphA2) | Eph | TK | 5ia4 | A | B | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 7168 | 0.42 | |
| MET | Met | TK | 6sdc | A | A | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 11532 | 0.42 | |
| EGFR | EGFR | TK | 4g5j | A | B | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 852 | 0.57 | |
| EGFR | EGFR | TK | 4i24 | B | | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 910 | 0.60 | |
| EPHA2 (EphA2) | Eph | TK | 5ia4 | A | A | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 7189 | 0.42 | |
| EGFR | EGFR | TK | 3ug2 | A | A | gefitinib | Human | 898 | 0.73 | |
| EGFR | EGFR | TK | 2ity | A | | gefitinib | Human | 790 | 0.73 | |
| GAK | NAK | Other | 5y80 | A | A | gefitinib | Human | 10329 | 0.73 | |
| GAK | NAK | Other | 5y7z | A | | gefitinib | Human | 10332 | 0.73 | |
| GAK | NAK | Other | 5y80 | A | B | gefitinib | Human | 10330 | 0.73 | |
| STK10 (LOK) | STE20 | STE | 6i2y | B | | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 10788 | 0.42 | |
| EPHB4 (EphB4) | Eph | TK | 2vwu | A | | n-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine | Human | 370 | 0.46 | |
| STK10 (LOK) | STE20 | STE | 6i2y | A | | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 10787 | 0.42 | |
| EGFR | EGFR | TK | 4i24 | A | | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 831 | 0.60 | |
| GAK | NAK | Other | 5y7z | B | | gefitinib | Human | 10331 | 0.73 | |
| EGFR | EGFR | TK | 2j5f | A | | n-[4-(3-bromo-phenylamino)-quinazolin-6-yl]-acrylamide | Human | 862 | 0.42 | |
| EGFR | EGFR | TK | 4i22 | A | | gefitinib | Human | 823 | 0.73 | |
| EGFR | EGFR | TK | 4wkq | A | A | gefitinib | Human | 889 | 0.73 | |
| EGFR | EGFR | TK | 4g5p | A | | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 809 | 0.57 | |
| MAPK14 (p38a) | MAPK | CMGC | 4a9y | A | | n-(3-{[7-methoxy-6-(2-pyrrolidin-1-ylethoxy)quinazolin-4-yl]amino}-4-methylphenyl)-2-morpholin-4-ylisonicotinamide | Human | 5073 | 0.42 | |
| EGFR | EGFR | TK | 3ug2 | A | B | gefitinib | Human | 819 | 0.73 | |
| MAPK14 (p38a) | MAPK | CMGC | 2bak | A | | n-(3-{[7-methoxy-6-(2-pyrrolidin-1-ylethoxy)quinazolin-4-yl]amino}-4-methylphenyl)-2-morpholin-4-ylisonicotinamide | Human | 5114 | 0.42 | |
| EGFR | EGFR | TK | 2ito | A | | gefitinib | Human | 783 | 0.73 | |
| EGFR | EGFR | TK | 2itz | A | | gefitinib | Human | 789 | 0.73 | |
| PKMYT1 (MYT1) | WEE | Other | 5vcw | B | | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide | Human | 8346 | 0.43 | |
| PKMYT1 (MYT1) | WEE | Other | 5vcw | A | | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide | Human | 8335 | 0.43 | |
| EGFR | EGFR | TK | 5y25 | A | | (2r)-n-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]-1-(2-fluoranylethanoyl)pyrrolidine-2-carboxamide | Human | 10373 | 0.72 | |
| EGFR | EGFR | TK | 4wkq | A | B | gefitinib | Human | 837 | 0.73 | |
| EGFR | EGFR | TK | 4g5j | A | A | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 794 | 0.57 | |
| EGFR | EGFR | TK | 4lqm | A | | n-[4-(3-bromo-phenylamino)-quinazolin-6-yl]-acrylamide | Human | 785 | 0.42 | |
| MET | Met | TK | 3lq8 | A | B | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 2964 | 0.42 | |
| MET | Met | TK | 3lq8 | A | A | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 2998 | 0.42 | |
| MET | Met | TK | 6sd9 | A | | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 11531 | 0.42 | |
| MET | Met | TK | 6sdc | A | B | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 11534 | 0.42 | |
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