| EGFR | EGFR | TK | 8eme | B | | n-{7-methyl-1-[(3s)-1-(prop-2-enoyl)azepan-3-yl]-1h-benzimidazol-2-yl}-5-(prop-2-enamido)thiophene-3-carboxamide | Human | 15375 | 0.52 | |
| EGFR | EGFR | TK | 5feq | A | | ~{n}-[1-[(3~{r})-1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-benzimidazol-2-yl]-2-methyl-pyridine-4-carboxamide | Human | 6883 | 0.90 | |
| EGFR | EGFR | TK | 5fee | A | | ~{n}-[7-methyl-1-[(3~{r})-1-propanoylazepan-3-yl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide | Human | 6881 | 0.54 | |
| FGFR1 | FGFR | TK | 6c19 | B | A | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(methylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 10855 | 0.41 | |
| FGFR1 | FGFR | TK | 6c1b | A | B | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 10861 | 0.40 | |
| FGFR1 | FGFR | TK | 6c1b | B | B | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 11167 | 0.40 | |
| FGFR1 | FGFR | TK | 6c19 | B | B | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(methylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 10862 | 0.41 | |
| FGFR1 | FGFR | TK | 6c1c | B | B | 7-(cyclohexylamino)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 11158 | 0.40 | |
| FGFR1 | FGFR | TK | 6c1c | A | A | 7-(cyclohexylamino)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 11164 | 0.40 | |
| FGFR1 | FGFR | TK | 6c1b | B | A | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 10856 | 0.40 | |
| FGFR1 | FGFR | TK | 6c19 | A | A | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(methylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 11163 | 0.41 | |
| FGFR1 | FGFR | TK | 6c19 | A | B | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(methylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 10859 | 0.41 | |
| FGFR1 | FGFR | TK | 6c1b | A | A | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 11169 | 0.40 | |
| FGFR1 | FGFR | TK | 6c1c | B | A | 7-(cyclohexylamino)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 10858 | 0.40 | |
| FGFR1 | FGFR | TK | 6c1c | A | B | 7-(cyclohexylamino)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 10853 | 0.40 | |
| EGFR | EGFR | TK | 5fed | A | | ~{n}-[7-methyl-1-[(3~{r})-1-propanoylazepan-3-yl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide | Human | 6882 | 0.54 | |
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