KLIFS - the structural kinase database

Searching for structures with analogs of Erlotinib.

Search results (31 entries covering 20 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
MAPK14 (p38a)	MAPK	CMGC	1di9	A		4-[3-methylsulfanylanilino]-6,7-dimethoxyquinazoline	Human	5251	0.51
AURKA (AurA)	Aur	Other	2c6e	A		n-{5-[(7-{[(2s)-2-hydroxy-3-piperidin-1-ylpropyl]oxy}-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide	Human	1989	0.41
EGFR	EGFR	TK	4hjo	A		[6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amine	Human	835	1.00
MERTK (MER)	Axl	TK	7avy	A		n-(2-(2-cyclopropylethoxy)pyrimidin-5-yl)-7-methoxy-6-(piperidin-4-ylmethoxy)quinazolin-4-amine	Human	13369	0.40
EGFR	EGFR	TK	1m17	A	B	[6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amine	Human	905	1.00
EGFR	EGFR	TK	3ug2	A	A	gefitinib	Human	898	0.42
EGFR	EGFR	TK	2ity	A		gefitinib	Human	790	0.42
GAK	NAK	Other	5y80	A	A	gefitinib	Human	10329	0.42
GAK	NAK	Other	5y7z	A		gefitinib	Human	10332	0.42
GAK	NAK	Other	5y80	A	B	gefitinib	Human	10330	0.42
CDK2	CDK	CMGC	1di8	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	4577	0.55
GAK	NAK	Other	5y7z	B		gefitinib	Human	10331	0.42
RIPK2	RIPK	TKL	6rn8	B		2-[4-(1,3-benzothiazol-5-ylamino)-6-~{tert}-butylsulfonyl-quinazolin-7-yl]oxyethyl dihydrogen phosphate	Human	11431	0.40
ABL1	Abl	TK	8ssn	A		6,7-dimethoxy-n-(4-phenoxyphenyl)quinazolin-4-amine	Human	14878	0.47
CSNK2A1 (CK2a1)	CK2	CMGC	3pe2	A	B	5-[(3-ethynylphenyl)amino]pyrimido[4,5-c]quinoline-8-carboxylic acid	Human	5519	0.43
CSNK2A1 (CK2a1)	CK2	CMGC	3pe2	A	A	5-[(3-ethynylphenyl)amino]pyrimido[4,5-c]quinoline-8-carboxylic acid	Human	5508	0.43
RET	Ret	TK	5amn	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	6412	0.55
EGFR	EGFR	TK	4i22	A		gefitinib	Human	823	0.42
EGFR	EGFR	TK	4wkq	A	A	gefitinib	Human	889	0.42
EGFR	EGFR	TK	3ug2	A	B	gefitinib	Human	819	0.42
EGFR	EGFR	TK	2ito	A		gefitinib	Human	783	0.42
EGFR	EGFR	TK	2itz	A		gefitinib	Human	789	0.42
AURKA (AurA)	Aur	Other	2c6e	B		n-{5-[(7-{[(2s)-2-hydroxy-3-piperidin-1-ylpropyl]oxy}-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide	Human	2046	0.41
RIPK2	RIPK	TKL	6rn8	A		2-[4-(1,3-benzothiazol-5-ylamino)-6-~{tert}-butylsulfonyl-quinazolin-7-yl]oxyethyl dihydrogen phosphate	Human	11434	0.40
TTBK1	TTBK	CK1	4btk	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	771	0.55
EGFR	EGFR	TK	4wkq	A	B	gefitinib	Human	837	0.42
EGFR	EGFR	TK	1m17	A	A	[6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amine	Human	873	1.00
TTBK2	TTBK	CK1	6u0k	A	A	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12046	0.55
TTBK2	TTBK	CK1	6u0k	B	B	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12047	0.55
TTBK2	TTBK	CK1	6u0k	A	B	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12048	0.55
TTBK2	TTBK	CK1	6u0k	B	A	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12049	0.55