Searching for structures with analogs of Naporafenib.

Search results (34 entries covering 14 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
EPHA2 (EphA2)EphTK6q7gAC3-[(4-imidazol-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamideHuman119340.44
EPHA2 (EphA2)EphTK6q7gAB3-[(4-imidazol-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamideHuman119380.44
EPHA2 (EphA2)EphTK6q7gAA3-[(4-imidazol-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamideHuman119330.44
BRAFRAFTKL5vamBAn-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamideHuman81860.44
MAP2K7STE7STE6yg6BA~{n}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{s})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamideHuman126730.41
MAP2K7STE7STE6yg7AB~{n}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{r})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamideHuman126740.41
MAP2K7STE7STE6yg6AA~{n}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{s})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamideHuman126760.41
MAP2K7STE7STE6yg7AA~{n}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{r})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamideHuman126830.41
MAP2K7STE7STE6yg6AB~{n}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{s})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamideHuman126870.41
MAP2K7STE7STE6yg6BB~{n}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{s})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamideHuman126940.41
MAP2K7STE7STE6yg7BB~{n}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{r})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamideHuman126850.41
MAP2K7STE7STE6yg7BA~{n}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{r})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamideHuman126960.41
MAPK14 (p38a)MAPKCMGC3kq7AAn-(2-methyl-5-{[(2-morpholin-4-ylpyridin-4-yl)carbonyl]amino}phenyl)-6-({2-[(2s)-1-methylpyrrolidin-2-yl]ethyl}amino)pyridine-3-carboxamideHuman50810.45
MAPK14 (p38a)MAPKCMGC4a9yAn-(3-{[7-methoxy-6-(2-pyrrolidin-1-ylethoxy)quinazolin-4-yl]amino}-4-methylphenyl)-2-morpholin-4-ylisonicotinamideHuman50730.42
MAPK14 (p38a)MAPKCMGC3d83An-{4'-[(cyclopropylmethyl)carbamoyl]-6-methylbiphenyl-3-yl}-2-morpholin-4-ylpyridine-4-carboxamideHuman50280.59
MAPK14 (p38a)MAPKCMGC3kq7ABn-(2-methyl-5-{[(2-morpholin-4-ylpyridin-4-yl)carbonyl]amino}phenyl)-6-({2-[(2s)-1-methylpyrrolidin-2-yl]ethyl}amino)pyridine-3-carboxamideHuman50570.45
MAPK14 (p38a)MAPKCMGC2bakAn-(3-{[7-methoxy-6-(2-pyrrolidin-1-ylethoxy)quinazolin-4-yl]amino}-4-methylphenyl)-2-morpholin-4-ylisonicotinamideHuman51140.42
LCKSrcTK2ofvA3-(2-aminoquinazolin-6-yl)-4-methyl-n-[3-(trifluoromethyl)phenyl]benzamideHuman22800.40
MAPK13 (p38d)MAPKCMGC4eymA2-(morpholin-4-yl)-n-[4-(pyridin-4-yloxy)phenyl]pyridine-4-carboxamideHuman29450.44
TEK (TIE2)TieTK2p4iA4-methyl-3-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)-n-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]benzamideHuman55490.40
TEK (TIE2)TieTK2p4iB4-methyl-3-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)-n-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]benzamideHuman55500.40
LCKSrcTK2ofvB3-(2-aminoquinazolin-6-yl)-4-methyl-n-[3-(trifluoromethyl)phenyl]benzamideHuman22940.40
BTKTecTK7kxmAB4-tert-butyl-n-(2-methyl-3-{2-[4-(morpholine-4-carbonyl)phenyl]-1h-imidazo[4,5-b]pyridin-7-yl}phenyl)benzamideHuman135640.40
BTKTecTK7kxmAC4-tert-butyl-n-(2-methyl-3-{2-[4-(morpholine-4-carbonyl)phenyl]-1h-imidazo[4,5-b]pyridin-7-yl}phenyl)benzamideHuman135670.40
BTKTecTK7kxmAA4-tert-butyl-n-(2-methyl-3-{2-[4-(morpholine-4-carbonyl)phenyl]-1h-imidazo[4,5-b]pyridin-7-yl}phenyl)benzamideHuman135690.40
BRAFRAFTKL5vamBBn-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamideHuman81870.44
BRAFRAFTKL5valBn-(3-tert-butylphenyl)-4-methyl-3-[6-(morpholin-4-yl)pyrimidin-4-yl]benzamideHuman81880.48
BRAFRAFTKL5vamAAn-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamideHuman81850.44
BRAFRAFTKL5valAn-(3-tert-butylphenyl)-4-methyl-3-[6-(morpholin-4-yl)pyrimidin-4-yl]benzamideHuman81900.48
BRAFRAFTKL5vamABn-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamideHuman81890.44
BRAFRAFTKL6n0pBAn-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamideHuman115941.00
BRAFRAFTKL6n0pAAn-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamideHuman115971.00
BRAFRAFTKL6n0pABn-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamideHuman115961.00
BRAFRAFTKL6n0pBBn-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamideHuman115951.00