| EGFR | EGFR | TK | 3w2s | A | B | 1-{3-[2-chloro-4-({5-[2-(2-hydroxyethoxy)ethyl]-5h-pyrrolo[3,2-d]pyrimidin-4-yl}amino)phenoxy]phenyl}-3-cyclohexylurea | Human | 792 | 0.54 | |
| EGFR | EGFR | TK | 3w2o | A | A | n-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide | Human | 9119 | 1.00 | |
| EGFR | EGFR | TK | 3w2r | A | A | 1-{3-[2-chloro-4-({5-[2-(2-hydroxyethoxy)ethyl]-5h-pyrrolo[3,2-d]pyrimidin-4-yl}amino)phenoxy]phenyl}-3-cyclohexylurea | Human | 822 | 0.54 | |
| EGFR | EGFR | TK | 3w2o | A | B | n-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide | Human | 9118 | 1.00 | |
| KDR | VEGFR | TK | 3vhe | A | | 1-{2-fluoro-4-[(5-methyl-5h-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}-3-[3-(trifluoromethyl)phenyl]urea | Human | 5331 | 0.41 | |
| EGFR | EGFR | TK | 3w2r | A | B | 1-{3-[2-chloro-4-({5-[2-(2-hydroxyethoxy)ethyl]-5h-pyrrolo[3,2-d]pyrimidin-4-yl}amino)phenoxy]phenyl}-3-cyclohexylurea | Human | 885 | 0.54 | |
| EGFR | EGFR | TK | 3w32 | A | | 4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-n-[2-(methylsulfonyl)ethyl]-8,9-dihydro-7h-pyrimido[4,5-b]azepine-6-carboxamide | Human | 784 | 0.51 | |
| EGFR | EGFR | TK | 3w2p | A | B | n-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-4-(dimethylamino)butanamide | Human | 838 | 0.81 | |
| EGFR | EGFR | TK | 3poz | A | | n-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide | Human | 7308 | 1.00 | |
| EGFR | EGFR | TK | 3w2p | A | A | n-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-4-(dimethylamino)butanamide | Human | 829 | 0.81 | |
| EGFR | EGFR | TK | 3w2s | A | A | 1-{3-[2-chloro-4-({5-[2-(2-hydroxyethoxy)ethyl]-5h-pyrrolo[3,2-d]pyrimidin-4-yl}amino)phenoxy]phenyl}-3-cyclohexylurea | Human | 778 | 0.54 | |
| ERBB2 (ErbB2) | EGFR | TK | 3pp0 | B | B | 2-{2-[4-({5-chloro-6-[3-(trifluoromethyl)phenoxy]pyridin-3-yl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol | Human | 4819 | 0.60 | |
| ERBB2 (ErbB2) | EGFR | TK | 3pp0 | A | A | 2-{2-[4-({5-chloro-6-[3-(trifluoromethyl)phenoxy]pyridin-3-yl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol | Human | 4815 | 0.60 | |
| ERBB2 (ErbB2) | EGFR | TK | 3pp0 | B | A | 2-{2-[4-({5-chloro-6-[3-(trifluoromethyl)phenoxy]pyridin-3-yl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol | Human | 4816 | 0.60 | |
| ERBB2 (ErbB2) | EGFR | TK | 3rcd | C | | n-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide | Human | 9323 | 1.00 | |
| ERBB2 (ErbB2) | EGFR | TK | 3pp0 | A | B | 2-{2-[4-({5-chloro-6-[3-(trifluoromethyl)phenoxy]pyridin-3-yl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol | Human | 4820 | 0.60 | |
| ERBB2 (ErbB2) | EGFR | TK | 3rcd | A | | n-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide | Human | 9325 | 1.00 | |
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