KLIFS - the structural kinase database

Searching for structures with analogs of Lirafugratinib.

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
FGFR2	FGFR	TK	8stg	A		n-{4-[(5p)-4-amino-5-{3-fluoro-4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7-methyl-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl}-2-methylprop-2-enamide	Human	14762	1.00
FGFR2	FGFR	TK	8u1f	A		n-[4-(4-amino-7-methyl-5-{4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7h-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-2-methylpropanamide	Human	15202	0.64
FGFR2	FGFR	TK	8swe	A	B	n-{4-[4-amino-5-(4-methoxyphenyl)-7-methyl-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl}prop-2-enamide	Human	15201	0.49
FGFR2	FGFR	TK	8swe	A	A	n-{4-[4-amino-5-(4-methoxyphenyl)-7-methyl-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl}prop-2-enamide	Human	15200	0.49