KLIFS - the structural kinase database

Searching for structures with analogs of Fasudil.

Search results (21 entries covering 11 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
PRKACA (PKACa)	PKA	AGC	3vqh	A	A	n-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide	Human	5271	0.44
PAK4	STE20	STE	5vef	A	A	5-(1,4-diazepan-1-sulfonyl)isoquinoline	Human	8569	1.00
AKT2	Akt	AGC	2jdo	A		isoquinoline-5-sulfonic acid (2-(2-(4-chlorobenzyloxy)ethylamino)ethyl)amide	Human	1922	0.44
ROCK1	DMPK	AGC	2etk	B		1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine	Human	2723	0.63
ROCK1	DMPK	AGC	3d9v	A		(s)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine	Human	2696	0.43
PRKACA (PKACa)	PKA	AGC	3vqh	A	B	n-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide	Human	5275	0.44
DAPK2	DAPK	CAMK	2cke	C		n-(2-aminoethyl)isoquinoline-5-sulfonamide	Human	1135	0.48
ROCK1	DMPK	AGC	3d9v	B		(s)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine	Human	2701	0.43
CSNK2A1 (CK2a1)	CK2	CMGC	8pvp	A		~{n}-[5-[(3-chloranyl-4-phenyl-phenyl)methylamino]pentyl]isoquinoline-5-sulfonamide	Human	14977	0.40
CDC42BPB (MRCKb)	DMPK	AGC	3tku	A		5-(1,4-diazepan-1-sulfonyl)isoquinoline	Human	4862	1.00
CDC42BPB (MRCKb)	DMPK	AGC	3tku	B		5-(1,4-diazepan-1-sulfonyl)isoquinoline	Human	4859	1.00
DAPK2	DAPK	CAMK	2cke	A		n-(2-aminoethyl)isoquinoline-5-sulfonamide	Human	1143	0.48
DAPK2	DAPK	CAMK	2cke	B		n-(2-aminoethyl)isoquinoline-5-sulfonamide	Human	1132	0.48
DAPK2	DAPK	CAMK	2cke	D		n-(2-aminoethyl)isoquinoline-5-sulfonamide	Human	1141	0.48
HASPIN (Haspin)	Haspin	Other	3fmd	A	B	n-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide	Human	3810	0.44
HASPIN (Haspin)	Haspin	Other	3fmd	A	A	n-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide	Human	3798	0.44
PAK4	STE20	STE	5vef	A	B	5-(1,4-diazepan-1-sulfonyl)isoquinoline	Human	8571	1.00
ROCK1	DMPK	AGC	2etk	A		1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine	Human	2707	0.63
ROCK1	DMPK	AGC	2esm	A		5-(1,4-diazepan-1-sulfonyl)isoquinoline	Human	2726	1.00
ROCK1	DMPK	AGC	2esm	B		5-(1,4-diazepan-1-sulfonyl)isoquinoline	Human	2714	1.00
Prkaca (PKACa)	PKA	AGC	2erz	E		1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine	Mouse	5895	0.63