KLIFS - the structural kinase database

Searching for structures with analogs of Ebvaciclib.

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
CDK2	CDK	CMGC	7kjs	A		6-(difluoromethyl)-8-[(1r,2r)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8h)-one	Human	13740	1.00
CDK2	CDK	CMGC	2wxv	C		n,1-dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]amino}-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide	Human	4504	0.42
CDK2	CDK	CMGC	8erd	A	A	(2-{[1-(methanesulfonyl)piperidin-4-yl]amino}quinazolin-7-yl)[(2s)-2-methylpyrrolidin-1-yl]methanone	Human	14949	0.49
CDK2	CDK	CMGC	8erd	A	B	(2-{[1-(methanesulfonyl)piperidin-4-yl]amino}quinazolin-7-yl)[(2s)-2-methylpyrrolidin-1-yl]methanone	Human	14951	0.49
CDK2	CDK	CMGC	2wxv	A		n,1-dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]amino}-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide	Human	4318	0.42
MAPK10 (JNK3)	MAPK	CMGC	4y46	A		1-{trans-4-[(8-cyclopentyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl}-3-propan-2-ylurea	Human	3414	0.42
CDK6	CDK	CMGC	8i0m	A		2-[(4-azanylcyclohexyl)amino]-7-cyclopentyl-~{n},~{n}-dimethyl-pyrrolo[2,3-d]pyrimidine-6-carboxamide	Human	15164	0.40
CDK9	CDK	CMGC	8i0l	A		2-[(4-azanylcyclohexyl)amino]-7-cyclopentyl-~{n},~{n}-dimethyl-pyrrolo[2,3-d]pyrimidine-6-carboxamide	Human	15170	0.40
CDK2	CDK	CMGC	2fvd	A		(4-amino-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone	Human	4408	0.42