| IRAK4 | IRAK | TKL | 6eg9 | A | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10905 | 0.42 | |
| KIT | PDGFR | TK | 1t46 | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 404 | 1.00 | |
| BTK | Tec | TK | 4ot5 | A | | 4-tert-butyl-n-{3-[8-({4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}amino)imidazo[1,2-a]pyrazin-6-yl]phenyl}benzamide | Human | 2913 | 0.42 | |
| EPHA2 (EphA2) | Eph | TK | 6het | A | B | ~{n}-(3-chlorophenyl)-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 11560 | 0.49 | |
| Abl1 (ABL1) | Abl | TK | 1fpu | B | | n-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-3-pyridinecarboxamide | Mouse | 5705 | 0.70 | |
| Abl1 (ABL1) | Abl | TK | 1iep | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5703 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 3k5v | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5723 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 6hd6 | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10610 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 3mss | B | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5730 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 3k5v | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5734 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 3k5v | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5722 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 3ik3 | B | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Mouse | 5739 | 0.42 | |
| EPHA2 (EphA2) | Eph | TK | 6q7g | A | C | 3-[(4-imidazol-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11934 | 0.40 | |
| EPHA2 (EphA2) | Eph | TK | 6q7g | A | A | 3-[(4-imidazol-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11933 | 0.40 | |
| EPHA2 (EphA2) | Eph | TK | 6het | A | A | ~{n}-(3-chlorophenyl)-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 11564 | 0.49 | |
| Abl1 (ABL1) | Abl | TK | 3ms9 | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5733 | 1.00 | |
| EPHA2 (EphA2) | Eph | TK | 6q7g | A | B | 3-[(4-imidazol-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11938 | 0.40 | |
| EPHB4 (EphB4) | Eph | TK | 6fnj | B | A | 4-methyl-3-[(2-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10340 | 0.44 | |
| EPHA2 (EphA2) | Eph | TK | 6hes | A | B | 4-methyl-3-[(2-pyridin-3-ylquinazolin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11566 | 0.41 | |
| Abl1 (ABL1) | Abl | TK | 6hd6 | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10611 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 6hd4 | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10648 | 1.00 | |
| MAPK11 (p38b) | MAPK | CMGC | 3gp0 | A | A | nilotinib | Human | 2768 | 0.54 | |
| MAPK11 (p38b) | MAPK | CMGC | 3gp0 | A | B | nilotinib | Human | 2764 | 0.54 | |
| EPHA2 (EphA2) | Eph | TK | 6q7e | A | B | 3-[[4-imidazol-1-yl-6-[(3~{r})-3-oxidanylpyrrolidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11932 | 0.40 | |
| ABL1 | Abl | TK | 6npu | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10942 | 1.00 | |
| EPHA2 (EphA2) | Eph | TK | 6q7b | A | B | 3-[[4-imidazol-1-yl-6-[(3~{s})-3-oxidanylpyrrolidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11935 | 0.40 | |
| EPHB4 (EphB4) | Eph | TK | 6fni | A | B | 4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10333 | 0.44 | |
| STK10 (LOK) | STE20 | STE | 4equ | B | A | n-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-3-(trifluoromethyl)benzamide | Human | 941 | 0.40 | |
| EPHB4 (EphB4) | Eph | TK | 6fnj | B | B | 4-methyl-3-[(2-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10341 | 0.44 | |
| EPHA2 (EphA2) | Eph | TK | 8bof | A | B | 4-methyl-~{n}-(3-methylphenyl)-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14652 | 0.47 | |
| BRAF | RAF | TKL | 6p3d | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 12809 | 0.42 | |
| EPHA2 (EphA2) | Eph | TK | 8bog | A | A | ~{n}-[4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]phenyl]-3-(trifluoromethyl)benzamide | Human | 14650 | 0.46 | |
| FGFR4 | FGFR | TK | 4uxq | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 930 | 0.42 | |
| FGFR4 | FGFR | TK | 4qrc | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 923 | 0.42 | |
| EPHB4 (EphB4) | Eph | TK | 6fni | A | A | 4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10338 | 0.44 | |
| EPHB4 (EphB4) | Eph | TK | 6fnj | A | A | 4-methyl-3-[(2-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10336 | 0.44 | |
| EPHA2 (EphA2) | Eph | TK | 6hes | A | A | 4-methyl-3-[(2-pyridin-3-ylquinazolin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11550 | 0.41 | |
| EPHB4 (EphB4) | Eph | TK | 6fnj | A | B | 4-methyl-3-[(2-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10334 | 0.44 | |
| DDR1 | DDR | TK | 4bkj | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 3263 | 1.00 | |
| RIPK2 | RIPK | TKL | 4c8b | B | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 1253 | 0.42 | |
| AURKA (AurA) | Aur | Other | 3h0z | A | | 4-{[2-({4-[2-(4-acetylpiperazin-1-yl)-2-oxoethyl]phenyl}amino)-5-fluoropyrimidin-4-yl]amino}-n-(2-chlorophenyl)benzamide | Human | 1970 | 0.41 | |
| ABL1 | Abl | TK | 5mo4 | A | B | nilotinib | Human | 7526 | 0.54 | |
| DDR1 | DDR | TK | 4bkj | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 3259 | 1.00 | |
| DDR1 | DDR | TK | 3zos | B | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3258 | 0.42 | |
| DDR1 | DDR | TK | 3zos | B | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3260 | 0.42 | |
| CSF1R (FMS) | PDGFR | TK | 4r7i | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 2307 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 3ms9 | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5708 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 6hd4 | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10645 | 1.00 | |
| AURKA (AurA) | Aur | Other | 3h0z | C | | 4-{[2-({4-[2-(4-acetylpiperazin-1-yl)-2-oxoethyl]phenyl}amino)-5-fluoropyrimidin-4-yl]amino}-n-(2-chlorophenyl)benzamide | Human | 2063 | 0.41 | |
| DDR1 | DDR | TK | 3zos | A | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3253 | 0.42 | |
| DDR1 | DDR | TK | 4bkj | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 3255 | 1.00 | |
| EPHA2 (EphA2) | Eph | TK | 8boc | A | A | ~{n}-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 15003 | 0.43 | |
| ABL1 | Abl | TK | 3pyy | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1049 | 1.00 | |
| IRAK4 | IRAK | TKL | 6eg9 | B | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10909 | 0.42 | |
| ALK | ALK | TK | 5iug | A | A | n-[3-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}-3-methylphenyl)-1h-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide | Human | 6640 | 0.42 | |
| ALK | ALK | TK | 5iui | A | B | n-[3-(4-amino-3-methylphenyl)-1h-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide | Human | 6642 | 0.47 | |
| EPHA2 (EphA2) | Eph | TK | 8bog | A | C | ~{n}-[4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]phenyl]-3-(trifluoromethyl)benzamide | Human | 14654 | 0.46 | |
| EPHA2 (EphA2) | Eph | TK | 8bof | A | A | 4-methyl-~{n}-(3-methylphenyl)-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14656 | 0.47 | |
| EPHA2 (EphA2) | Eph | TK | 8boh | A | A | 4-methyl-~{n}-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14647 | 0.40 | |
| EPHA2 (EphA2) | Eph | TK | 8boh | A | B | 4-methyl-~{n}-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14651 | 0.40 | |
| EPHA2 (EphA2) | Eph | TK | 8boi | A | B | 4-methyl-~{n}-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14655 | 0.54 | |
| MAPK10 (JNK3) | MAPK | CMGC | 3v6r | A | A | 4-{[4-(dimethylamino)butanoyl]amino}-n-(3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide | Human | 3441 | 0.51 | |
| IRAK4 | IRAK | TKL | 6eg9 | B | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10911 | 0.42 | |
| MAPK8 (JNK1) | MAPK | CMGC | 8x5m | A | B | 3-[4-(dimethylamino)butanoylamino]-~{n}-[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide | Human | 15100 | 0.53 | |
| FGFR4 | FGFR | TK | 4tyj | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 925 | 0.42 | |
| EPHA2 (EphA2) | Eph | TK | 8boi | A | A | 4-methyl-~{n}-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14645 | 0.54 | |
| EPHA2 (EphA2) | Eph | TK | 8bod | A | B | ~{n}-[3,5-bis(chloranyl)phenyl]-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14646 | 0.47 | |
| MAPK8 (JNK1) | MAPK | CMGC | 8x5m | A | A | 3-[4-(dimethylamino)butanoylamino]-~{n}-[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide | Human | 15099 | 0.53 | |
| AURKA (AurA) | Aur | Other | 3h0z | B | | 4-{[2-({4-[2-(4-acetylpiperazin-1-yl)-2-oxoethyl]phenyl}amino)-5-fluoropyrimidin-4-yl]amino}-n-(2-chlorophenyl)benzamide | Human | 1986 | 0.41 | |
| EPHA2 (EphA2) | Eph | TK | 6q7c | A | A | 3-[[4-imidazol-1-yl-6-[(3~{s})-3-oxidanylpiperidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11931 | 0.40 | |
| Abl1 (ABL1) | Abl | TK | 3ms9 | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5713 | 1.00 | |
| EPHA2 (EphA2) | Eph | TK | 8bog | A | B | ~{n}-[4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]phenyl]-3-(trifluoromethyl)benzamide | Human | 14649 | 0.46 | |
| EPHA2 (EphA2) | Eph | TK | 6fnf | A | B | 4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10420 | 0.44 | |
| EPHA2 (EphA2) | Eph | TK | 6q7c | A | B | 3-[[4-imidazol-1-yl-6-[(3~{s})-3-oxidanylpiperidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11930 | 0.40 | |
| EPHA2 (EphA2) | Eph | TK | 6hev | A | B | 4-methyl-3-[(2-pyridin-3-ylpyrido[2,3-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11565 | 0.42 | |
| EPHA2 (EphA2) | Eph | TK | 6q7b | A | A | 3-[[4-imidazol-1-yl-6-[(3~{s})-3-oxidanylpyrrolidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11927 | 0.40 | |
| EPHA2 (EphA2) | Eph | TK | 6fng | A | A | 4-methyl-3-[(2-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10414 | 0.44 | |
| EPHA2 (EphA2) | Eph | TK | 8bom | A | B | ~{n}-(3-methoxyphenyl)-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14653 | 0.45 | |
| EPHA2 (EphA2) | Eph | TK | 6fnf | A | A | 4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10417 | 0.44 | |
| EPHA2 (EphA2) | Eph | TK | 8bok | A | A | ~{n}-(3,5-dimethoxyphenyl)-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14648 | 0.43 | |
| EPHA2 (EphA2) | Eph | TK | 6heu | A | B | 3-[(4,6-dipyridin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11552 | 0.40 | |
| EPHA2 (EphA2) | Eph | TK | 6q7e | A | A | 3-[[4-imidazol-1-yl-6-[(3~{r})-3-oxidanylpyrrolidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11926 | 0.40 | |
| EPHA2 (EphA2) | Eph | TK | 6hey | A | B | 3-[(4,6-dipyridin-3-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11558 | 0.48 | |
| EPHA2 (EphA2) | Eph | TK | 6fng | A | B | 4-methyl-3-[(2-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10416 | 0.44 | |
| EPHA2 (EphA2) | Eph | TK | 6heu | A | A | 3-[(4,6-dipyridin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11563 | 0.40 | |
| EPHA2 (EphA2) | Eph | TK | 6hev | A | A | 4-methyl-3-[(2-pyridin-3-ylpyrido[2,3-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11561 | 0.42 | |
| EPHA2 (EphA2) | Eph | TK | 6hey | A | A | 3-[(4,6-dipyridin-3-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11557 | 0.48 | |
| EPHA2 (EphA2) | Eph | TK | 8boc | A | B | ~{n}-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 15002 | 0.43 | |
| EPHA2 (EphA2) | Eph | TK | 8bom | A | A | ~{n}-(3-methoxyphenyl)-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14658 | 0.45 | |
| EPHA2 (EphA2) | Eph | TK | 8bok | A | B | ~{n}-(3,5-dimethoxyphenyl)-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14659 | 0.43 | |
| EPHA2 (EphA2) | Eph | TK | 8bod | A | A | ~{n}-[3,5-bis(chloranyl)phenyl]-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14657 | 0.47 | |
| RIPK2 | RIPK | TKL | 4c8b | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 1254 | 0.42 | |
| DDR1 | DDR | TK | 3zos | A | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3262 | 0.42 | |
| ABL1 | Abl | TK | 3cs9 | B | B | nilotinib | Human | 1112 | 0.54 | |
| ABL1 | Abl | TK | 6npv | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10949 | 1.00 | |
| ABL1 | Abl | TK | 2hyy | C | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1048 | 1.00 | |
| ABL1 | Abl | TK | 6npv | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10948 | 1.00 | |
| ABL1 | Abl | TK | 3pyy | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1098 | 1.00 | |
| ABL1 | Abl | TK | 3pyy | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1071 | 1.00 | |
| ABL1 | Abl | TK | 6npe | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10947 | 1.00 | |
| ABL1 | Abl | TK | 2hyy | B | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1078 | 1.00 | |
| ABL1 | Abl | TK | 6npv | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10950 | 1.00 | |
| ABL1 | Abl | TK | 6npe | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10945 | 1.00 | |
| ABL1 | Abl | TK | 3cs9 | C | A | nilotinib | Human | 1046 | 0.54 | |
| ABL1 | Abl | TK | 2hyy | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1092 | 1.00 | |
| ABL1 | Abl | TK | 3pyy | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1062 | 1.00 | |
| ABL1 | Abl | TK | 3cs9 | C | B | nilotinib | Human | 1093 | 0.54 | |
| ABL1 | Abl | TK | 3cs9 | D | B | nilotinib | Human | 1066 | 0.54 | |
| ABL1 | Abl | TK | 5hu9 | A | B | 4-[(4-methylpiperazin-1-yl)methyl]-n-(4-methyl-3-{[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]oxy}phenyl)-3-(trifluoromethyl)benzamide | Human | 6755 | 0.42 | |
| ABL1 | Abl | TK | 3cs9 | A | A | nilotinib | Human | 1080 | 0.54 | |
| ABL1 | Abl | TK | 5hu9 | A | A | 4-[(4-methylpiperazin-1-yl)methyl]-n-(4-methyl-3-{[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]oxy}phenyl)-3-(trifluoromethyl)benzamide | Human | 6754 | 0.42 | |
| ABL1 | Abl | TK | 2e2b | A | | n-[3-(4,5'-bipyrimidin-2-ylamino)-4-methylphenyl]-4-{[(3s)-3-(dimethylamino)pyrrolidin-1-yl]methyl}-3-(trifluoromethyl)benzamide | Human | 1054 | 0.56 | |
| ABL1 | Abl | TK | 6npu | B | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10944 | 1.00 | |
| ABL1 | Abl | TK | 5mo4 | A | A | nilotinib | Human | 7527 | 0.54 | |
| ABL1 | Abl | TK | 2hyy | D | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1068 | 1.00 | |
| ABL1 | Abl | TK | 6npe | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10943 | 1.00 | |
| ABL1 | Abl | TK | 6npv | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10951 | 1.00 | |
| ABL1 | Abl | TK | 6npe | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10946 | 1.00 | |
| ABL1 | Abl | TK | 3cs9 | A | B | nilotinib | Human | 1107 | 0.54 | |
| ABL1 | Abl | TK | 3cs9 | B | A | nilotinib | Human | 1050 | 0.54 | |
| JAK2 | JakA | TK | 4d1s | A | B | 2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1h-pyrrole-3-carboxamide | Human | 3627 | 0.42 | |
| JAK2 | JakA | TK | 4d1s | A | A | 2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1h-pyrrole-3-carboxamide | Human | 3634 | 0.42 | |
| SYK | Syk | TK | 1xbb | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1196 | 1.00 | |
| SYK | Syk | TK | 1xbb | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1184 | 1.00 | |
| SRC | Src | TK | 1y57 | A | | 4-[(4-methylpiperazin-1-yl)methyl]-n-{3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide | Human | 986 | 0.82 | |
| SRC | Src | TK | 7ote | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 14240 | 0.42 | |
| MAPK10 (JNK3) | MAPK | CMGC | 3v6r | B | A | 4-{[4-(dimethylamino)butanoyl]amino}-n-(3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide | Human | 3427 | 0.51 | |
| MAPK10 (JNK3) | MAPK | CMGC | 3v6r | A | B | 4-{[4-(dimethylamino)butanoyl]amino}-n-(3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide | Human | 3436 | 0.51 | |
| MAPK10 (JNK3) | MAPK | CMGC | 3v6r | B | B | 4-{[4-(dimethylamino)butanoyl]amino}-n-(3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide | Human | 3417 | 0.51 | |
| MAPK10 (JNK3) | MAPK | CMGC | 3v6s | A | B | 3-{[4-(dimethylamino)butanoyl]amino}-n-(4-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide | Human | 3449 | 0.50 | |
| MAPK10 (JNK3) | MAPK | CMGC | 3v6s | B | B | 3-{[4-(dimethylamino)butanoyl]amino}-n-(4-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide | Human | 3425 | 0.50 | |
| FGFR1 | FGFR | TK | 4v01 | A | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3556 | 0.42 | |
| FGFR1 | FGFR | TK | 4v01 | A | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3590 | 0.42 | |
| FGFR1 | FGFR | TK | 4v04 | A | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3542 | 0.42 | |
| FGFR1 | FGFR | TK | 4v01 | B | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3497 | 0.42 | |
| FGFR1 | FGFR | TK | 4v04 | B | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3524 | 0.42 | |
| FGFR1 | FGFR | TK | 4v01 | B | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3594 | 0.42 | |
| MAPK14 (p38a) | MAPK | CMGC | 3hec | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 5166 | 1.00 | |
| MAPK14 (p38a) | MAPK | CMGC | 3hec | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 5035 | 1.00 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 5grn | A | B | n-[2-(dimethylamino)ethyl]-n-[[4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methyl]pyridine-3-carboxamide | Human | 9478 | 0.64 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 5grn | A | A | n-[2-(dimethylamino)ethyl]-n-[[4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methyl]pyridine-3-carboxamide | Human | 9479 | 0.64 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 6jol | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 12103 | 1.00 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | A | B | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13390 | 0.46 | |
| ACVR1 (ALK2) | STKR | TKL | 6jux | A | B | 4-(1-ethyl-3-pyridin-3-yl-pyrazol-4-yl)-~{n}-(4-piperazin-1-ylphenyl)pyrimidin-2-amine | Human | 12160 | 0.43 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | B | B | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13391 | 0.46 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | B | A | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13392 | 0.46 | |
| KIT | PDGFR | TK | 4u0i | A | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 405 | 0.42 | |
| KIT | PDGFR | TK | 1t46 | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 393 | 1.00 | |
| KIT | PDGFR | TK | 4u0i | A | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 396 | 0.42 | |
| ABL2 | Abl | TK | 3gvu | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 109 | 1.00 | |
| ABL2 | Abl | TK | 3gvu | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 117 | 1.00 | |
| LCK | Src | TK | 2pl0 | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 2290 | 1.00 | |
| LCK | Src | TK | 3bys | A | | 4-methyl-n~3~-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl)-n~1~-[3-(trifluoromethyl)phenyl]benzene-1,3-dicarboxamide | Human | 2293 | 0.42 | |
| ROR1 | Ror | TK | 6tu9 | B | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 11945 | 0.42 | |
| ROR1 | Ror | TK | 6tu9 | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 11944 | 0.42 | |
| IRAK4 | IRAK | TKL | 6eg9 | A | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10906 | 0.42 | |
| ALK | ALK | TK | 5iui | A | A | n-[3-(4-amino-3-methylphenyl)-1h-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide | Human | 6641 | 0.47 | |
| ALK | ALK | TK | 5iug | A | B | n-[3-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}-3-methylphenyl)-1h-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide | Human | 6639 | 0.42 | |
| ALK | ALK | TK | 5iuh | A | | 4-[(4-methylpiperazin-1-yl)methyl]-n-{3-[3-methyl-4-({[5-(propan-2-yl)-1,2-oxazol-3-yl]carbamoyl}amino)phenyl]-1h-pyrazol-5-yl}benzamide | Human | 6638 | 0.46 | |
| PDPK1 (PDK1) | PDK1 | AGC | 2xck | A | | 1-methyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-n-[(2-methylpyridin-4-yl)methyl]-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 3201 | 0.42 | |
| TEK (TIE2) | Tie | TK | 2osc | A | | n-{4-methyl-3-[(3-pyrimidin-4-ylpyridin-2-yl)amino]phenyl}-3-(trifluoromethyl)benzamide | Human | 5555 | 0.40 | |
| STK10 (LOK) | STE20 | STE | 4equ | A | A | n-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-3-(trifluoromethyl)benzamide | Human | 957 | 0.40 | |
| STK10 (LOK) | STE20 | STE | 4equ | B | B | n-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-3-(trifluoromethyl)benzamide | Human | 959 | 0.40 | |
| STK10 (LOK) | STE20 | STE | 4equ | A | B | n-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-3-(trifluoromethyl)benzamide | Human | 938 | 0.40 | |
| BTK | Tec | TK | 6w07 | A | A | ~{n}-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-3-propan-2-yloxy-azetidine-1-carboxamide | Human | 13096 | 0.40 | |
| BTK | Tec | TK | 6w07 | A | C | ~{n}-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-3-propan-2-yloxy-azetidine-1-carboxamide | Human | 13097 | 0.40 | |
| BTK | Tec | TK | 6w07 | A | B | ~{n}-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-3-propan-2-yloxy-azetidine-1-carboxamide | Human | 13102 | 0.40 | |
| Abl1 (ABL1) | Abl | TK | 1opj | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5732 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 3mss | C | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5719 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 3ik3 | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Mouse | 5731 | 0.42 | |
| Abl1 (ABL1) | Abl | TK | 6hd6 | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10608 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 1iep | B | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5727 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 1opj | B | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5736 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 6hd6 | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10609 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 3ms9 | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5706 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 3oxz | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Mouse | 5721 | 0.42 | |
| Abl1 (ABL1) | Abl | TK | 3mss | D | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5702 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 1fpu | A | | n-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-3-pyridinecarboxamide | Mouse | 5728 | 0.70 | |
| Abl1 (ABL1) | Abl | TK | 6hd4 | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10646 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 6hd4 | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10647 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 3k5v | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5710 | 1.00 | |
| Abl1 (ABL1) | Abl | TK | 3mss | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5724 | 1.00 | |
| DDR1 | DDR | TK | 4bkj | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 3256 | 1.00 | |
| ABL1 | Abl | TK | 2e2b | B | | n-[3-(4,5'-bipyrimidin-2-ylamino)-4-methylphenyl]-4-{[(3s)-3-(dimethylamino)pyrrolidin-1-yl]methyl}-3-(trifluoromethyl)benzamide | Human | 1065 | 0.56 | |
| ABL1 | Abl | TK | 3cs9 | D | A | nilotinib | Human | 1077 | 0.54 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | A | A | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13389 | 0.46 | |
| ACVR1 (ALK2) | STKR | TKL | 6jux | A | A | 4-(1-ethyl-3-pyridin-3-yl-pyrazol-4-yl)-~{n}-(4-piperazin-1-ylphenyl)pyrimidin-2-amine | Human | 12161 | 0.43 | |
Match: