| ERBB3 (ErbB3) | EGFR | TK | 6op9 | A | A | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 11545 | 0.43 | |
| STK10 (LOK) | STE20 | STE | 5ajq | B | A | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 940 | 0.43 | |
| STK10 (LOK) | STE20 | STE | 4bc6 | A | A | 4-[(3,5-dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 942 | 0.47 | |
| STK10 (LOK) | STE20 | STE | 5ajq | B | B | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 948 | 0.43 | |
| STK24 (MST3) | STE20 | STE | 4qmn | A | B | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 5604 | 0.43 | |
| STK10 (LOK) | STE20 | STE | 4bc6 | A | B | 4-[(3,5-dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 961 | 0.47 | |
| STK10 (LOK) | STE20 | STE | 5ajq | A | B | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 955 | 0.43 | |
| SIK3 (QSK) | CAMKL | CAMK | 8r4q | A | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 15241 | 0.43 | |
| SRC | Src | TK | 4mxo | B | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 978 | 0.43 | |
| CAMK2A (CaMK2a) | CAMK2 | CAMK | 3soa | A | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 2473 | 0.43 | |
| STK24 (MST3) | STE20 | STE | 4qmn | A | A | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 5587 | 0.43 | |
| ULK3 | ULK | Other | 6fdy | U | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 10389 | 0.43 | |
| PKMYT1 (MYT1) | WEE | Other | 5vcy | A | A | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 8345 | 0.43 | |
| PKMYT1 (MYT1) | WEE | Other | 5vcy | A | B | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 8338 | 0.43 | |
| PKMYT1 (MYT1) | WEE | Other | 5vcz | A | B | 4-[(3,5-dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 8336 | 0.47 | |
| PKMYT1 (MYT1) | WEE | Other | 5vcz | A | A | 4-[(3,5-dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 8342 | 0.47 | |
| EPHA2 (EphA2) | Eph | TK | 5i9x | A | B | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 7177 | 0.43 | |
| EPHA2 (EphA2) | Eph | TK | 5i9x | A | A | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 7182 | 0.43 | |
| ABL1 | Abl | TK | 3ue4 | B | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 1074 | 0.43 | |
| ABL1 | Abl | TK | 3ue4 | A | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 1057 | 0.43 | |
| SRC | Src | TK | 4mxy | A | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 982 | 0.43 | |
| SRC | Src | TK | 4mxy | B | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 972 | 0.43 | |
| SRC | Src | TK | 4mxz | A | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 969 | 0.43 | |
| SRC | Src | TK | 4mxz | B | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 988 | 0.43 | |
| SRC | Src | TK | 4mxx | B | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 976 | 0.43 | |
| SRC | Src | TK | 4mxo | A | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 990 | 0.43 | |
| SRC | Src | TK | 4mxx | A | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 989 | 0.43 | |
| WEE1 (Wee1) | WEE | Other | 5vc3 | A | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 8329 | 0.43 | |
| IGF1R | InsR | TK | 3f5p | F | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1029 | 0.64 | |
| IGF1R | InsR | TK | 3f5p | H | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1006 | 0.64 | |
| IGF1R | InsR | TK | 3f5p | I | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1016 | 0.64 | |
| IGF1R | InsR | TK | 3f5p | K | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1013 | 0.64 | |
| IGF1R | InsR | TK | 3f5p | C | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1022 | 0.64 | |
| IGF1R | InsR | TK | 3f5p | D | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1015 | 0.64 | |
| IGF1R | InsR | TK | 3f5p | M | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1001 | 0.64 | |
| IGF1R | InsR | TK | 3f5p | T | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1037 | 0.64 | |
| IGF1R | InsR | TK | 3f5p | E | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1042 | 0.64 | |
| IGF1R | InsR | TK | 3f5p | S | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 996 | 0.64 | |
| IGF1R | InsR | TK | 3f5p | G | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1005 | 0.64 | |
| IGF1R | InsR | TK | 3f5p | R | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1019 | 0.64 | |
| IGF1R | InsR | TK | 3f5p | B | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1044 | 0.64 | |
| IGF1R | InsR | TK | 3f5p | L | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1039 | 0.64 | |
| IGF1R | InsR | TK | 3f5p | A | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 995 | 0.64 | |
| ERBB3 (ErbB3) | EGFR | TK | 6op9 | A | B | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 11544 | 0.43 | |
| STK10 (LOK) | STE20 | STE | 5ajq | A | A | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 950 | 0.43 | |
| WEE1 (Wee1) | WEE | Other | 5vc4 | A | | 4-[(3,5-dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 8334 | 0.47 | |
| IGF1R | InsR | TK | 3f5p | J | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1040 | 0.64 | |
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