KLIFS - the structural kinase database

Searching for structures with analogs of Selonsertib.

Search results (29 entries covering 9 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
MAP3K5	STE11	STE	7mu7	A	B	3-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-1-(pyrazin-2-yl)-1h-pyrazole-4-carboxamide	Human	14220	0.52
MAP3K5	STE11	STE	6vre	A	B	3-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-1-(pyrazin-2-yl)-1h-pyrazole-4-carboxamide	Human	12233	0.52
MAP3K5	STE11	STE	6e2o	B		4-(4-cyclopropyl-1h-imidazol-1-yl)-n-[3-(4-cyclopropyl-4h-1,2,4-triazol-3-yl)phenyl]pyridine-2-carboxamide	Human	10573	0.41
MAP3K5	STE11	STE	6xih	A	B	(2r)-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}oxane-2-carboxamide	Human	12700	0.53
MAP3K5	STE11	STE	5vil	A		2-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-5-sulfamoylbenzamide	Human	9512	0.54
MAP3K5	STE11	STE	6vre	B	B	3-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-1-(pyrazin-2-yl)-1h-pyrazole-4-carboxamide	Human	12234	0.52
MAP3K5	STE11	STE	5v24	B	A	2-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]-n-(pyridin-2-yl)-1,3-thiazole-4-carboxamide	Human	8026	0.43
MAP3K5	STE11	STE	6e2o	A		4-(4-cyclopropyl-1h-imidazol-1-yl)-n-[3-(4-cyclopropyl-4h-1,2,4-triazol-3-yl)phenyl]pyridine-2-carboxamide	Human	10574	0.41
MAP3K5	STE11	STE	5up3	A		2-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-2,3-dihydro-1h-isoindol-1-one	Human	8105	0.40
MAP3K5	STE11	STE	6oyt	A		5-(4-cyclopropyl-1h-imidazol-1-yl)-2-fluoro-4-methyl-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}benzamide	Human	11837	1.00
MAP3K5	STE11	STE	6xih	B	B	(2r)-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}oxane-2-carboxamide	Human	12701	0.53
MAP3K5	STE11	STE	6vre	B	A	3-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-1-(pyrazin-2-yl)-1h-pyrazole-4-carboxamide	Human	12235	0.52
MAP3K5	STE11	STE	5v24	A	B	2-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]-n-(pyridin-2-yl)-1,3-thiazole-4-carboxamide	Human	8021	0.43
MAP3K5	STE11	STE	6oyt	B		5-(4-cyclopropyl-1h-imidazol-1-yl)-2-fluoro-4-methyl-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}benzamide	Human	11835	1.00
MAP3K5	STE11	STE	6xih	B	A	(2r)-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}oxane-2-carboxamide	Human	12702	0.53
MAP3K5	STE11	STE	5vio	A		4-methoxy-n~1~-methyl-n~3~-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}benzene-1,3-dicarboxamide	Human	9510	0.53
MAP3K5	STE11	STE	6oyt	D		5-(4-cyclopropyl-1h-imidazol-1-yl)-2-fluoro-4-methyl-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}benzamide	Human	11844	1.00
MAP3K5	STE11	STE	5vio	D		4-methoxy-n~1~-methyl-n~3~-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}benzene-1,3-dicarboxamide	Human	9505	0.53
MAP3K5	STE11	STE	5vio	B		4-methoxy-n~1~-methyl-n~3~-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}benzene-1,3-dicarboxamide	Human	9507	0.53
MAP3K5	STE11	STE	5v24	A	A	2-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]-n-(pyridin-2-yl)-1,3-thiazole-4-carboxamide	Human	8022	0.43
MAP3K5	STE11	STE	5up3	B		2-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-2,3-dihydro-1h-isoindol-1-one	Human	8110	0.40
MAP3K5	STE11	STE	6xih	A	A	(2r)-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}oxane-2-carboxamide	Human	12703	0.53
MAP3K5	STE11	STE	6oyt	C		5-(4-cyclopropyl-1h-imidazol-1-yl)-2-fluoro-4-methyl-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}benzamide	Human	11840	1.00
MAP3K5	STE11	STE	5vil	B		2-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-5-sulfamoylbenzamide	Human	9509	0.54
MAP3K5	STE11	STE	5vil	D		2-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-5-sulfamoylbenzamide	Human	9508	0.54
MAP3K5	STE11	STE	7mu7	A	A	3-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-1-(pyrazin-2-yl)-1h-pyrazole-4-carboxamide	Human	14221	0.52
MAP3K5	STE11	STE	5v24	B	B	2-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]-n-(pyridin-2-yl)-1,3-thiazole-4-carboxamide	Human	8023	0.43
MAP3K5	STE11	STE	6vre	A	A	3-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-1-(pyrazin-2-yl)-1h-pyrazole-4-carboxamide	Human	12236	0.52
MAP3K5	STE11	STE	5vil	C		2-methoxy-n-{6-[4-(propan-2-yl)-4h-1,2,4-triazol-3-yl]pyridin-2-yl}-5-sulfamoylbenzamide	Human	9506	0.54