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Searching for structures with analogs of
Dacomitinib
.
Search results (30 entries covering 21 PDB structures)
#
Kinase
Family
Group
PDB
Chain
(Alternate) Model
Orthosteric ligand
Organism
Details
Similarity (MFP)
File
EGFR
EGFR
TK
7u9a
A
4-(5-chloro-4-fluoro-2-hydroxyanilino)-7-methoxyquinazolin-6-ol
Human
14527
0.45
EGFR
EGFR
TK
4i23
A
(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide
Human
870
1.00
AURKA (AurA)
Aur
Other
2c6e
A
n-{5-[(7-{[(2s)-2-hydroxy-3-piperidin-1-ylpropyl]oxy}-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide
Human
1989
0.46
EGFR
EGFR
TK
4g5j
A
B
n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide
Human
852
0.52
EGFR
EGFR
TK
7a6j
A
B
1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one
Human
14124
0.42
EGFR
EGFR
TK
3ug2
A
A
gefitinib
Human
898
0.54
GAK
NAK
Other
5y80
A
A
gefitinib
Human
10329
0.54
GAK
NAK
Other
5y7z
A
gefitinib
Human
10332
0.54
EGFR
EGFR
TK
4i24
A
(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide
Human
831
1.00
GAK
NAK
Other
5y7z
B
gefitinib
Human
10331
0.54
EGFR
EGFR
TK
8f1y
A
1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one
Human
14940
0.42
EGFR
EGFR
TK
8f1w
A
1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one
Human
14944
0.42
EGFR
EGFR
TK
3ug2
A
B
gefitinib
Human
819
0.54
EGFR
EGFR
TK
2ito
A
gefitinib
Human
783
0.54
EGFR
EGFR
TK
2itz
A
gefitinib
Human
789
0.54
AURKA (AurA)
Aur
Other
2c6e
B
n-{5-[(7-{[(2s)-2-hydroxy-3-piperidin-1-ylpropyl]oxy}-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide
Human
2046
0.46
PKMYT1 (MYT1)
WEE
Other
5vcw
B
(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide
Human
8346
0.49
PKMYT1 (MYT1)
WEE
Other
5vcw
A
(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide
Human
8335
0.49
EGFR
EGFR
TK
5y25
A
(2r)-n-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]-1-(2-fluoranylethanoyl)pyrrolidine-2-carboxamide
Human
10373
0.53
EGFR
EGFR
TK
4g5j
A
A
n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide
Human
794
0.52
GAK
NAK
Other
5y80
A
B
gefitinib
Human
10330
0.54
EPHB4 (EphB4)
Eph
TK
2vwu
A
n-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine
Human
370
0.43
RET
Ret
TK
2ivu
A
4-bromo-2-fluoro-n-[(4e)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4(1h)-ylidene]aniline
Human
3364
0.40
EGFR
EGFR
TK
4i22
A
gefitinib
Human
823
0.54
EGFR
EGFR
TK
4wkq
A
A
gefitinib
Human
889
0.54
EGFR
EGFR
TK
4g5p
A
n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide
Human
809
0.52
EGFR
EGFR
TK
4wkq
A
B
gefitinib
Human
837
0.54
EGFR
EGFR
TK
4i24
B
(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide
Human
910
1.00
EGFR
EGFR
TK
2ity
A
gefitinib
Human
790
0.54
EGFR
EGFR
TK
7a6j
A
A
1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one
Human
14125
0.42
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Dacomitinib
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