KLIFS - the structural kinase database

Searching for structures with analogs of Dacomitinib.

Search results (34 entries covering 25 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
EGFR	EGFR	TK	4i23	A		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	870	1.00
AURKA (AurA)	Aur	Other	2c6e	A		n-{5-[(7-{[(2s)-2-hydroxy-3-piperidin-1-ylpropyl]oxy}-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide	Human	1989	0.46
EGFR	EGFR	TK	7a6j	A	B	1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one	Human	14124	0.42
EGFR	EGFR	TK	3ug2	A	A	gefitinib	Human	898	0.54
GAK	NAK	Other	5y80	A	A	gefitinib	Human	10329	0.54
GAK	NAK	Other	5y7z	A		gefitinib	Human	10332	0.54
EGFR	EGFR	TK	4i24	A		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	831	1.00
EGFR	EGFR	TK	4i22	A		gefitinib	Human	823	0.54
EGFR	EGFR	TK	2ity	A		gefitinib	Human	790	0.54
EGFR	EGFR	TK	4wkq	A	A	gefitinib	Human	889	0.54
EGFR	EGFR	TK	4wkq	A	B	gefitinib	Human	837	0.54
GAK	NAK	Other	5y7z	B		gefitinib	Human	10331	0.54
EGFR	EGFR	TK	9ou9	A		4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl (2r)-2,4-dimethylpiperazine-1-carboxylate	Human	15880	0.42
ILK	MLK	TKL	9d5e	A		gefitinib	Human	15992	0.54
ILK	MLK	TKL	9d5h	A		gefitinib	Human	15989	0.54
EGFR	EGFR	TK	8f1y	A		1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one	Human	14940	0.42
EGFR	EGFR	TK	8f1w	A		1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one	Human	14944	0.42
EGFR	EGFR	TK	3ug2	A	B	gefitinib	Human	819	0.54
EGFR	EGFR	TK	2ito	A		gefitinib	Human	783	0.54
EGFR	EGFR	TK	2itz	A		gefitinib	Human	789	0.54
AURKA (AurA)	Aur	Other	2c6e	B		n-{5-[(7-{[(2s)-2-hydroxy-3-piperidin-1-ylpropyl]oxy}-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide	Human	2046	0.46
PKMYT1 (MYT1)	WEE	Other	5vcw	B		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide	Human	8346	0.49
PKMYT1 (MYT1)	WEE	Other	5vcw	A		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide	Human	8335	0.49
EGFR	EGFR	TK	5y25	A		(2r)-n-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]-1-(2-fluoranylethanoyl)pyrrolidine-2-carboxamide	Human	10373	0.53
EGFR	EGFR	TK	4g5j	A	A	n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide	Human	794	0.52
EGFR	EGFR	TK	7a6j	A	A	1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one	Human	14125	0.42
EPHB4 (EphB4)	Eph	TK	2vwu	A		n-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine	Human	370	0.43
GAK	NAK	Other	5y80	A	B	gefitinib	Human	10330	0.54
EGFR	EGFR	TK	4g5p	A		n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide	Human	809	0.52
EGFR	EGFR	TK	9os6	A		canertinib	Human	15893	0.60
RET	Ret	TK	2ivu	A		4-bromo-2-fluoro-n-[(4e)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4(1h)-ylidene]aniline	Human	3364	0.40
EGFR	EGFR	TK	4g5j	A	B	n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide	Human	852	0.52
EGFR	EGFR	TK	4i24	B		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	910	1.00
EGFR	EGFR	TK	7u9a	A		4-(5-chloro-4-fluoro-2-hydroxyanilino)-7-methoxyquinazolin-6-ol	Human	14527	0.45