| JAK2 | JakA | TK | 5tq6 | A | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}(pyrrolidin-1-yl)methanone | Human | 7354 | 0.43 | |
| BTK | Tec | TK | 7n4r | A | B | n-{2-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]ethyl}-n~2~-phenylglycinamide | Human | 14228 | 0.41 | |
| BTK | Tec | TK | 7n4r | A | A | n-{2-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]ethyl}-n~2~-phenylglycinamide | Human | 14226 | 0.41 | |
| BTK | Tec | TK | 8flv | A | C | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}ethan-1-one | Human | 14697 | 0.49 | |
| BTK | Tec | TK | 8flv | A | A | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}ethan-1-one | Human | 14698 | 0.49 | |
| BTK | Tec | TK | 8flv | A | B | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}ethan-1-one | Human | 14699 | 0.49 | |
| BTK | Tec | TK | 8flh | A | A | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]azepan-1-yl}ethan-1-one | Human | 14637 | 0.49 | |
| BTK | Tec | TK | 8flh | A | B | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]azepan-1-yl}ethan-1-one | Human | 14638 | 0.49 | |
| JAK1 | JakA | TK | 5khx | A | A | ~{n}-[3-[methyl(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | Human | 7167 | 0.57 | |
| JAK1 | JakA | TK | 6bbu | A | A | n-{cis-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | Human | 9497 | 0.61 | |
| JAK1 | JakA | TK | 5khx | A | B | ~{n}-[3-[methyl(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | Human | 7166 | 0.57 | |
| BTK | Tec | TK | 7n4r | A | C | n-{2-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]ethyl}-n~2~-phenylglycinamide | Human | 14225 | 0.41 | |
| JAK3 | JakA | TK | 3lxk | A | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 436 | 0.42 | |
| BTK | Tec | TK | 8flh | A | C | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]azepan-1-yl}ethan-1-one | Human | 14639 | 0.49 | |
| JAK2 | JakA | TK | 5tq7 | B | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}[(3r)-3-(phenylsulfonyl)pyrrolidin-1-yl]methanone | Human | 7353 | 0.44 | |
| PKN1 | PKN | AGC | 4oti | A | A | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 551 | 0.42 | |
| PKN1 | PKN | AGC | 4oti | A | B | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 547 | 0.42 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6qaw | A | B | [1-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methylazanium | Human | 10986 | 0.40 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6qaw | A | A | [1-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methylazanium | Human | 10984 | 0.40 | |
| JAK2 | JakA | TK | 5tq7 | A | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}[(3r)-3-(phenylsulfonyl)pyrrolidin-1-yl]methanone | Human | 7355 | 0.44 | |
| JAK2 | JakA | TK | 5tq6 | B | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}(pyrrolidin-1-yl)methanone | Human | 7361 | 0.43 | |
| JAK2 | JakA | TK | 6bbv | A | | n-{cis-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | Human | 9504 | 0.61 | |
| JAK2 | JakA | TK | 3fup | B | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 3654 | 0.42 | |
| JAK2 | JakA | TK | 3fup | A | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 3721 | 0.42 | |
| TYK2 | JakA | TK | 3lxn | A | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 3337 | 0.42 | |
| JAK1 | JakA | TK | 3eyg | A | A | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 1445 | 0.42 | |
| JAK1 | JakA | TK | 3eyg | A | B | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 1453 | 0.42 | |
| JAK1 | JakA | TK | 6bbu | A | B | n-{cis-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | Human | 9496 | 0.61 | |