Searching for structures with analogs of -.

Search results (27 entries covering 15 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
CDK2CDKCMGC4acmAB3-amino-6-(4-{[2-(dimethylamino)ethyl]sulfamoyl}phenyl)-n-pyridin-3-ylpyrazine-2-carboxamideHuman39830.55
PIK3CG (p110g)PIKAtypical4anwAA3-amino-6-{4-chloro-3-[(2,3-difluorophenyl)sulfamoyl]phenyl}-n-methylpyrazine-2-carboxamideHuman91740.45
PIK3CG (p110g)PIKAtypical4anwAB3-amino-6-{4-chloro-3-[(2,3-difluorophenyl)sulfamoyl]phenyl}-n-methylpyrazine-2-carboxamideHuman91750.45
PIK3CG (p110g)PIKAtypical4anuA3-amino-n-methyl-6-[3-(1h-tetrazol-5-yl)phenyl]pyrazine-2-carboxamideHuman91620.43
MAP4K4 (HGK)STE20STE5di1A4-{6-amino-5-[4-(methylsulfonyl)phenyl]pyridin-3-yl}phenolHuman63540.43
SYKSykTK4dflA3-amino-6-{3-[(methylsulfonyl)amino]phenyl}-n-(piperidin-4-ylmethyl)pyrazine-2-carboxamideHuman11520.45
KITPDGFRTK7khkA4,5-dimethyl-n-(2-phenyl-1h-pyrrolo[2,3-b]pyridin-5-yl)-1h-pyrazole-3-carboxamideHuman137870.40
GSK3BGSKCMGC6hk4AB3-azanyl-6-(4-morpholin-4-ylsulfonylphenyl)-~{n}-pyridin-3-yl-pyrazine-2-carboxamideHuman114230.54
CDK2CDKCMGC4acmAA3-amino-6-(4-{[2-(dimethylamino)ethyl]sulfamoyl}phenyl)-n-pyridin-3-ylpyrazine-2-carboxamideHuman42470.55
CDK2CDKCMGC2vtlAn-phenyl-1h-pyrazole-3-carboxamideHuman38700.40
CDK2CDKCMGC2vtiAn-(4-sulfamoylphenyl)-1h-indazole-3-carboxamideHuman41770.40
GSK3BGSKCMGC6hk3BB3-azanyl-~{n}-(2-methoxyphenyl)-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]pyrazine-2-carboxamideHuman114240.53
GSK3BGSKCMGC4achA3-amino-n-(3-methoxypropyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamideHuman6530.45
GSK3BGSKCMGC6hk4BB3-azanyl-6-(4-morpholin-4-ylsulfonylphenyl)-~{n}-pyridin-3-yl-pyrazine-2-carboxamideHuman114270.54
GSK3BGSKCMGC4acdA3-amino-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-n-pyridin-3-ylpyrazine-2-carboxamideHuman7230.56
GSK3BGSKCMGC4achB3-amino-n-(3-methoxypropyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamideHuman7020.45
GSK3BGSKCMGC4accB3-amino-6-(4-{[2-(dimethylamino)ethyl]sulfamoyl}phenyl)-n-pyridin-3-ylpyrazine-2-carboxamideHuman6690.55
GSK3BGSKCMGC6hk4AA3-azanyl-6-(4-morpholin-4-ylsulfonylphenyl)-~{n}-pyridin-3-yl-pyrazine-2-carboxamideHuman114290.54
GSK3BGSKCMGC6hk4BA3-azanyl-6-(4-morpholin-4-ylsulfonylphenyl)-~{n}-pyridin-3-yl-pyrazine-2-carboxamideHuman114300.54
GSK3BGSKCMGC6hk3BA3-azanyl-~{n}-(2-methoxyphenyl)-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]pyrazine-2-carboxamideHuman114220.53
GSK3BGSKCMGC6hk7A3-azanyl-~{n}-(2-methoxyethyl)-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]pyrazine-2-carboxamideHuman114280.45
GSK3BGSKCMGC4acdB3-amino-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-n-pyridin-3-ylpyrazine-2-carboxamideHuman6920.56
GSK3BGSKCMGC6hk3AA3-azanyl-~{n}-(2-methoxyphenyl)-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]pyrazine-2-carboxamideHuman114250.53
GSK3BGSKCMGC6hk3AB3-azanyl-~{n}-(2-methoxyphenyl)-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]pyrazine-2-carboxamideHuman114260.53
GSK3BGSKCMGC4accA3-amino-6-(4-{[2-(dimethylamino)ethyl]sulfamoyl}phenyl)-n-pyridin-3-ylpyrazine-2-carboxamideHuman7040.55
PIK3CA (p110a)PIKAtypical5ul1AB3-amino-6-(4-{[(2s)-1-(dimethylamino)propan-2-yl]sulfonyl}phenyl)-n-phenylpyrazine-2-carboxamideHuman93080.69
PIK3CA (p110a)PIKAtypical5ul1AA3-amino-6-(4-{[(2s)-1-(dimethylamino)propan-2-yl]sulfonyl}phenyl)-n-phenylpyrazine-2-carboxamideHuman93160.69