KLIFS - the structural kinase database

Searching for structures with analogs of Amdizalisib.

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
PIK3CD (p110d)	PIK	Atypical	5m6u	A		4-azanyl-6-[[(1~{s})-1-(4-oxidanylidene-3-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile	Human	9094	0.44
PIK3CG (p110g)	PIK	Atypical	5kae	A		4-azanyl-6-[[(1~{s})-1-(6-fluoranyl-3-phenyl-4-piperazin-1-ylcarbonyl-quinolin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile	Human	9241	0.42
PIK3CG (p110g)	PIK	Atypical	5eds	A		4-azanyl-6-[[(1~{s})-1-[6-fluoranyl-1-(3-methylsulfonylphenyl)benzimidazol-2-yl]ethyl]amino]pyrimidine-5-carbonitrile	Human	9208	0.40
Pik3cd (p110d)	PIK	Atypical	5ncy	A	A	4-azanyl-6-[[(1~{s})-1-(3-methyl-5-oxidanylidene-6-phenyl-[1,3]thiazolo[3,2-a]pyridin-7-yl)ethyl]amino]pyrimidine-5-carbonitrile	Mouse	9379	0.54
Pik3cd (p110d)	PIK	Atypical	5ncy	A	B	4-azanyl-6-[[(1~{s})-1-(3-methyl-5-oxidanylidene-6-phenyl-[1,3]thiazolo[3,2-a]pyridin-7-yl)ethyl]amino]pyrimidine-5-carbonitrile	Mouse	9357	0.54
Pik3cd (p110d)	PIK	Atypical	5ncz	A	B	4-azanyl-6-[[(1~{s})-1-[6-[3-[(dimethylamino)methyl]phenyl]-3-methyl-5-oxidanylidene-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile	Mouse	9388	0.46
Pik3cd (p110d)	PIK	Atypical	5ncz	A	A	4-azanyl-6-[[(1~{s})-1-[6-[3-[(dimethylamino)methyl]phenyl]-3-methyl-5-oxidanylidene-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile	Mouse	9396	0.46