KLIFS - the structural kinase database

Searching for structures with analogs of Itacitinib.

Search results (15 entries covering 5 PDB structures)

Kinase	Family	Group	PDB	Chain	Orthosteric ligand	Organism	Details	Similarity (MFP)
BMP2K (BIKE)	NAK	Other	4w9x	A	baricitinib	Human	3273	0.56
JAK2	JakA	TK	6vgl	D	(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13220	0.43
JAK2	JakA	TK	6vgl	C	(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13221	0.43
JAK2	JakA	TK	6vgl	B	(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13222	0.43
JAK2	JakA	TK	6vgl	A	(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13223	0.43
JAK2	JakA	TK	6vn8	A	baricitinib	Human	13291	0.56
JAK2	JakA	TK	6vnk	D	(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13292	0.43
JAK2	JakA	TK	6vnk	A	(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13293	0.43
JAK2	JakA	TK	6vnk	B	(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13295	0.43
JAK2	JakA	TK	6vn8	B	baricitinib	Human	13301	0.56
JAK2	JakA	TK	6vnk	C	(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13304	0.43
JAK2	JakA	TK	6vsn	D	(3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13343	0.43
JAK2	JakA	TK	6vsn	C	(3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13350	0.43
JAK2	JakA	TK	6vsn	A	(3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13353	0.43
JAK2	JakA	TK	6vsn	B	(3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13356	0.43