KLIFS - the structural kinase database

Searching for structures with analogs of -.

Search results (45 entries covering 8 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
EGFR	EGFR	TK	6wa2	D	A	n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide	Human	13439	0.42
EGFR	EGFR	TK	6v6k	D	A	n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide	Human	12223	0.43
EGFR	EGFR	TK	6wa2	C	A	n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide	Human	13447	0.42
EGFR	EGFR	TK	6wa2	D	B	n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide	Human	13437	0.42
EGFR	EGFR	TK	6vhn	A		n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide	Human	12171	0.43
CSNK1D (CK1d)	CK1	CK1	5mqv	D	B	4-(2,5-dimethoxyphenyl)-n-(4-(5-(4-fluorphenyl)-2-(methylthio)-1h-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1h-pyrrole-2-carboxamide	Human	7539	0.47
CSNK1D (CK1d)	CK1	CK1	5mqv	B	A	4-(2,5-dimethoxyphenyl)-n-(4-(5-(4-fluorphenyl)-2-(methylthio)-1h-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1h-pyrrole-2-carboxamide	Human	7542	0.47
EGFR	EGFR	TK	6v6k	B	A	n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide	Human	12202	0.43
EGFR	EGFR	TK	6v6k	F	A	n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide	Human	12204	0.43
EGFR	EGFR	TK	6wa2	B	A	n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide	Human	13443	0.42
CSNK1D (CK1d)	CK1	CK1	5mqv	A	B	4-(2,5-dimethoxyphenyl)-n-(4-(5-(4-fluorphenyl)-2-(methylthio)-1h-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1h-pyrrole-2-carboxamide	Human	7534	0.47
EGFR	EGFR	TK	6v6k	G	B	n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide	Human	12222	0.43
CSNK1D (CK1d)	CK1	CK1	5mqv	C	B	4-(2,5-dimethoxyphenyl)-n-(4-(5-(4-fluorphenyl)-2-(methylthio)-1h-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1h-pyrrole-2-carboxamide	Human	7535	0.47
CSNK1D (CK1d)	CK1	CK1	5mqv	E	B	4-(2,5-dimethoxyphenyl)-n-(4-(5-(4-fluorphenyl)-2-(methylthio)-1h-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1h-pyrrole-2-carboxamide	Human	7538	0.47
TGFBR1 (TGFbR1)	STKR	TKL	5qik	A	A	n-{4-[3-(6-fluoropyridin-3-yl)-4-oxo-4,5,6,7-tetrahydro-1h-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}acetamide	Human	10657	0.43
CSNK1D (CK1d)	CK1	CK1	5mqv	F	A	4-(2,5-dimethoxyphenyl)-n-(4-(5-(4-fluorphenyl)-2-(methylthio)-1h-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1h-pyrrole-2-carboxamide	Human	7536	0.47
CSNK1D (CK1d)	CK1	CK1	5mqv	D	A	4-(2,5-dimethoxyphenyl)-n-(4-(5-(4-fluorphenyl)-2-(methylthio)-1h-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1h-pyrrole-2-carboxamide	Human	7537	0.47
CSNK1D (CK1d)	CK1	CK1	5mqv	C	A	4-(2,5-dimethoxyphenyl)-n-(4-(5-(4-fluorphenyl)-2-(methylthio)-1h-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1h-pyrrole-2-carboxamide	Human	7541	0.47
CSNK1D (CK1d)	CK1	CK1	5mqv	B	B	4-(2,5-dimethoxyphenyl)-n-(4-(5-(4-fluorphenyl)-2-(methylthio)-1h-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1h-pyrrole-2-carboxamide	Human	7540	0.47
EGFR	EGFR	TK	6v6k	A	B	n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide	Human	12168	0.43
EGFR	EGFR	TK	6wa2	C	B	n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide	Human	13436	0.42
EGFR	EGFR	TK	6v6k	A	A	n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide	Human	12179	0.43
EGFR	EGFR	TK	6v6k	B	B	n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide	Human	12229	0.43
EGFR	EGFR	TK	6v6k	F	B	n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide	Human	12214	0.43
EGFR	EGFR	TK	6wa2	B	B	n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide	Human	13444	0.42
EGFR	EGFR	TK	6v6k	H	A	n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide	Human	12216	0.43
EGFR	EGFR	TK	6v6k	E	B	n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide	Human	12193	0.43
EGFR	EGFR	TK	6v6k	G	A	n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide	Human	12195	0.43
CSNK1D (CK1d)	CK1	CK1	5mqv	E	A	4-(2,5-dimethoxyphenyl)-n-(4-(5-(4-fluorphenyl)-2-(methylthio)-1h-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1h-pyrrole-2-carboxamide	Human	7543	0.47
CSNK1D (CK1d)	CK1	CK1	5mqv	F	B	4-(2,5-dimethoxyphenyl)-n-(4-(5-(4-fluorphenyl)-2-(methylthio)-1h-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1h-pyrrole-2-carboxamide	Human	7533	0.47
MAPK10 (JNK3)	MAPK	CMGC	7orf	A	A	n-[4-[[4-[5-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-imidazol-4-yl]pyridin-2-yl]amino]phenyl]-3-(propanoylamino)benzamide	Human	13812	0.61
CSNK1D (CK1d)	CK1	CK1	5mqv	A	A	4-(2,5-dimethoxyphenyl)-n-(4-(5-(4-fluorphenyl)-2-(methylthio)-1h-imidazol-4-yl)-pyridin-2-yl)-1-methyl-1h-pyrrole-2-carboxamide	Human	7532	0.47
MAPK10 (JNK3)	MAPK	CMGC	7ore	A	B	4-(dimethylamino)-n-[(5z)-9-[[4-[5-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-imidazol-4-yl]pyridin-2-yl]amino]-11,12-dihydrobenzo[c][1,2]benzodiazocin-2-yl]butanamide	Human	13810	0.61
MAPK10 (JNK3)	MAPK	CMGC	7ore	A	A	4-(dimethylamino)-n-[(5z)-9-[[4-[5-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-imidazol-4-yl]pyridin-2-yl]amino]-11,12-dihydrobenzo[c][1,2]benzodiazocin-2-yl]butanamide	Human	13811	0.61
MAPK10 (JNK3)	MAPK	CMGC	7ore	A	C	4-(dimethylamino)-n-[(5z)-9-[[4-[5-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-imidazol-4-yl]pyridin-2-yl]amino]-11,12-dihydrobenzo[c][1,2]benzodiazocin-2-yl]butanamide	Human	13813	0.61
MAPK10 (JNK3)	MAPK	CMGC	7orf	A	B	n-[4-[[4-[5-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-imidazol-4-yl]pyridin-2-yl]amino]phenyl]-3-(propanoylamino)benzamide	Human	13814	0.61
MAPK14 (p38a)	MAPK	CMGC	5ml5	A		3-(2,5-dimethoxyphenyl)-~{n}-[4-[4-(4-fluorophenyl)-2-methylsulfanyl-1~{h}-imidazol-5-yl]pyridin-2-yl]propanamide	Human	7544	0.45
EGFR	EGFR	TK	6v6k	E	A	n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide	Human	12187	0.43
EGFR	EGFR	TK	6wa2	A	A	n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide	Human	13434	0.42
EGFR	EGFR	TK	6v6k	H	B	n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide	Human	12190	0.43
EGFR	EGFR	TK	6v6k	C	A	n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide	Human	12207	0.43
EGFR	EGFR	TK	6v6k	C	B	n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide	Human	12209	0.43
EGFR	EGFR	TK	6v6k	D	B	n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide	Human	12212	0.43
EGFR	EGFR	TK	6wa2	A	B	n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide	Human	13442	0.42
TGFBR1 (TGFbR1)	STKR	TKL	5qik	A	B	n-{4-[3-(6-fluoropyridin-3-yl)-4-oxo-4,5,6,7-tetrahydro-1h-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}acetamide	Human	10662	0.43