KLIFS - the structural kinase database

Searching for structures with analogs of Capivasertib.

Search results (13 entries covering 7 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
AKT2	Akt	AGC	2x39	A		4-amino-n-(4-chlorobenzyl)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	Human	1913	0.68
AKT2	Akt	AGC	2xh5	A		4-(4-tert-butylbenzyl)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium	Human	1924	0.47
AKT1	Akt	AGC	3ocb	A		(2s)-2-(4-chlorobenzyl)-3-oxo-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]propan-1-amine	Human	2548	0.57
AKT1	Akt	AGC	4gv1	A	B	4-amino-n-[(1s)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	Human	2536	1.00
JAK3	JakA	TK	5ttu	A	A	1-[(3ar,7ar)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)octahydro-6h-pyrrolo[2,3-c]pyridin-6-yl]propan-1-one	Human	7435	0.44
JAK3	JakA	TK	5ttu	A	B	1-[(3ar,7ar)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)octahydro-6h-pyrrolo[2,3-c]pyridin-6-yl]propan-1-one	Human	7438	0.44
AKT1	Akt	AGC	3ocb	B		(2s)-2-(4-chlorobenzyl)-3-oxo-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]propan-1-amine	Human	2534	0.57
AKT1	Akt	AGC	4gv1	A	A	4-amino-n-[(1s)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	Human	2543	1.00
MAPK1 (Erk2)	MAPK	CMGC	6qaw	A	B	[1-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methylazanium	Human	10986	0.45
MAPK1 (Erk2)	MAPK	CMGC	6qaw	A	A	[1-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methylazanium	Human	10984	0.45
JAK3	JakA	TK	7c3n	A	B	3-[(3s,4r)-3-methyl-7-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile	Human	12391	0.46
JAK3	JakA	TK	7c3n	A	C	3-[(3s,4r)-3-methyl-7-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile	Human	12390	0.46
JAK3	JakA	TK	7c3n	A	A	3-[(3s,4r)-3-methyl-7-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile	Human	12389	0.46