KLIFS - the structural kinase database

Searching for structures with analogs of Lifirafenib.

Kinase	Family	Group	PDB	Chain	Orthosteric ligand	Organism	Details	Similarity (MFP)
BRAF	RAF	TKL	4r5y	B	5-({(1r,1as,6br)-1-[5-(trifluoromethyl)-1h-benzimidazol-2-yl]-1a,6b-dihydro-1h-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1h)-one	Human	6413	0.90
BRAF	RAF	TKL	4r5y	A	5-({(1r,1as,6br)-1-[5-(trifluoromethyl)-1h-benzimidazol-2-yl]-1a,6b-dihydro-1h-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1h)-one	Human	6414	0.90
BRAF	RAF	TKL	3q96	B	(2s)-n-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide	Human	3089	0.43
BRAF	RAF	TKL	3q96	A	(2s)-n-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide	Human	3072	0.43