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Searching for structures with analogs of
Merestinib
.
Search results (11 entries covering 6 PDB structures)
#
Kinase
Family
Group
PDB
Chain
(Alternate) Model
Orthosteric ligand
Organism
Details
Similarity (MFP)
File
MET
Met
TK
3f82
A
n-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Human
2977
0.41
MET
Met
TK
4eev
A
A
n-(3-fluoro-4-{[1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Human
3012
1.00
MET
Met
TK
4eev
A
B
n-(3-fluoro-4-{[1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Human
3023
1.00
MET
Met
TK
3ce3
A
1-(4-fluorophenyl)-n-[3-fluoro-4-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide
Human
6769
0.43
Ripk3 (RIPK3)
RIPK
TKL
6oko
A
A
1-(4-fluorophenyl)-n-[3-fluoro-4-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide
Mouse
11438
0.43
Ripk3 (RIPK3)
RIPK
TKL
6oko
B
B
1-(4-fluorophenyl)-n-[3-fluoro-4-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide
Mouse
11441
0.43
MET
Met
TK
6sdd
A
n-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Human
11533
0.41
Ripk3 (RIPK3)
RIPK
TKL
6oko
B
A
1-(4-fluorophenyl)-n-[3-fluoro-4-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide
Mouse
11440
0.43
Ripk3 (RIPK3)
RIPK
TKL
6oko
A
B
1-(4-fluorophenyl)-n-[3-fluoro-4-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide
Mouse
11439
0.43
MERTK (MER)
Axl
TK
7aay
A
B
n-(3-fluoro-4-{[1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Human
12935
1.00
MERTK (MER)
Axl
TK
7aay
A
A
n-(3-fluoro-4-{[1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
Human
12940
1.00
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Merestinib
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