KLIFS - the structural kinase database

Searching for structures with analogs of Naquotinib.

Search results (11 entries covering 9 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
MAP3K7 (TAK1)	MLK	TKL	5jh6	A		2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl prop-2-enoate	Human	7427	0.42
MAP3K7 (TAK1)	MLK	TKL	5j9l	A		n-(4-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide	Human	7426	0.43
MAP3K7 (TAK1)	MLK	TKL	5j8i	A		n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide	Human	7428	0.42
EGFR	EGFR	TK	5ugb	A		4-(4-{[2-{[(3s)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9h-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium	Human	7515	0.42
EGFR	EGFR	TK	5uga	A	A	4-(4-{[2-{[(3s)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9h-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium	Human	7517	0.42
EGFR	EGFR	TK	5uga	A	B	4-(4-{[2-{[(3s)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9h-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium	Human	7511	0.42
EGFR	EGFR	TK	5y9t	A		6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3r)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazine-2-carboxamide	Human	10053	1.00
FLT3	PDGFR	TK	6jqr	A		6-ethyl-3-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide	Human	11802	0.56
MAP2K7	STE7	STE	6yg3	A	B	n-(4-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide	Human	12681	0.43
MAP2K7	STE7	STE	6yg3	A	A	n-(4-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide	Human	12689	0.43
MERTK (MER)	Axl	TK	7ab1	A		6-ethyl-3-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide	Human	12933	0.56