KLIFS - the structural kinase database

Searching for structures with analogs of -.

Search results (43 entries covering 7 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
BMPR1B	STKR	TKL	3mdy	C	B	4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1500	0.43
BMPR1B	STKR	TKL	3mdy	C	A	4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1503	0.43
BMPR1B	STKR	TKL	3mdy	A	A	4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1502	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	I		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1261	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	N		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1257	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	J		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1277	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	G		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1272	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	C		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1269	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	S		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1259	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	R		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1256	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	T		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1264	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	A		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1266	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	O		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1262	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	L		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1265	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	M		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1268	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	V		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1271	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	E		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1263	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	H		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1260	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	D		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1258	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	B		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1273	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	X		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1275	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	P		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1270	0.43
BMPR1B	STKR	TKL	3mdy	A	B	4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1501	0.43
DCLK1	DCAMKL	CAMK	5jzn	A		5-chloro-n-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-n'-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine	Human	6986	0.40
FES	Fer	TK	4e93	A	B	5-chloro-n-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-n'-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine	Human	2809	0.40
DCLK1	DCAMKL	CAMK	5jzn	B		5-chloro-n-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-n'-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine	Human	6982	0.40
FES	Fer	TK	4e93	A	A	5-chloro-n-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-n'-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine	Human	2816	0.40
ACVRL1 (ALK1)	STKR	TKL	3my0	F		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1276	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	Q		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1274	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	U		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1278	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	W		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1255	0.43
ACVRL1 (ALK1)	STKR	TKL	3my0	K		4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1267	0.43
ACVR1 (ALK2)	STKR	TKL	3q4u	B	A	4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1510	0.43
ACVR1 (ALK2)	STKR	TKL	3q4u	C	B	4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1533	0.43
ACVR1 (ALK2)	STKR	TKL	3q4u	A	A	4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1527	0.43
ACVR1 (ALK2)	STKR	TKL	6uns	A	B	4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	13781	0.43
ACVR1 (ALK2)	STKR	TKL	6uns	A	A	4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	13782	0.43
ACVR1 (ALK2)	STKR	TKL	3q4u	D	B	4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1529	0.43
ACVR1 (ALK2)	STKR	TKL	3q4u	B	B	4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1523	0.43
ACVR1 (ALK2)	STKR	TKL	3q4u	C	A	4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1516	0.43
ACVR1 (ALK2)	STKR	TKL	3q4u	A	B	4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1524	0.43
ACVR1 (ALK2)	STKR	TKL	3q4u	D	A	4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	Human	1520	0.43
ALK	ALK	TK	2xb7	A		5-chloro-n-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-n'-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine	Human	5365	0.40