KLIFS - the structural kinase database

Searching for structures with analogs of -.

Search results (27 entries covering 9 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
FGFR1	FGFR	TK	4wun	B	B	n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide	Human	3565	0.74
CDK2	CDK	CMGC	4ek4	A	C	4-bromo-n-(5-methyl-1h-pyrazol-3-yl)benzamide	Human	4369	0.40
CDK2	CDK	CMGC	4ek5	A	B	n-(5-cyclopropyl-1h-pyrazol-3-yl)benzene-1,4-dicarboxamide	Human	4145	0.40
FGFR4	FGFR	TK	5nwz	A		~{n}-[3-[2-(3,5-dimethoxyphenyl)ethyl]-1~{h}-pyrazol-5-yl]-2-(propanoylamino)benzamide	Human	9789	0.42
CDK2	CDK	CMGC	4ek4	A	A	4-bromo-n-(5-methyl-1h-pyrazol-3-yl)benzamide	Human	4212	0.40
CDK2	CDK	CMGC	4fkg	A	A	4-[(5-cyclopropyl-1h-pyrazol-3-yl)carbamoyl]benzoic acid	Human	4020	0.41
FGFR4	FGFR	TK	5nwz	B		~{n}-[3-[2-(3,5-dimethoxyphenyl)ethyl]-1~{h}-pyrazol-5-yl]-2-(propanoylamino)benzamide	Human	9788	0.42
FGFR1	FGFR	TK	4v05	B	B	n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide	Human	3493	0.74
FGFR1	FGFR	TK	4nk9	B		n~4~-{5-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-3-yl}-n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine	Human	3535	0.40
FGFR1	FGFR	TK	4rwk	A	B	n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide	Human	3517	0.74
CDK2	CDK	CMGC	4fkg	A	B	4-[(5-cyclopropyl-1h-pyrazol-3-yl)carbamoyl]benzoic acid	Human	4559	0.41
CDK2	CDK	CMGC	4ek5	A	A	n-(5-cyclopropyl-1h-pyrazol-3-yl)benzene-1,4-dicarboxamide	Human	4037	0.40
FGFR1	FGFR	TK	4rwk	A	A	n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide	Human	3500	0.74
FGFR1	FGFR	TK	4rwk	B	A	n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide	Human	3591	0.74
FGFR1	FGFR	TK	4nk9	A		n~4~-{5-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-3-yl}-n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine	Human	3550	0.40
CDK2	CDK	CMGC	4ek4	A	B	4-bromo-n-(5-methyl-1h-pyrazol-3-yl)benzamide	Human	3957	0.40
FGFR1	FGFR	TK	4wun	A	B	n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide	Human	3595	0.74
FGFR1	FGFR	TK	4v05	A	B	n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide	Human	3593	0.74
FGFR1	FGFR	TK	4rwj	B	B	n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide	Human	3559	0.74
FGFR1	FGFR	TK	4rwj	B	A	n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide	Human	3579	0.74
FGFR1	FGFR	TK	4v05	A	A	n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide	Human	3560	0.74
FGFR1	FGFR	TK	4wun	A	A	n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide	Human	3511	0.74
FGFR1	FGFR	TK	4v05	B	A	n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide	Human	3518	0.74
FGFR1	FGFR	TK	4rwj	A	B	n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide	Human	3519	0.74
FGFR1	FGFR	TK	4rwj	A	A	n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide	Human	3584	0.74
FGFR1	FGFR	TK	4rwk	B	B	n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide	Human	3530	0.74
FGFR1	FGFR	TK	4wun	B	A	n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide	Human	3529	0.74