KLIFS - the structural kinase database

Searching for structures with analogs of Deucravacitinib.

Search results (12 entries covering 4 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
TYK2-b	JakB	TK	7k7o	A	A	6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide	Human	13835	0.73
TYK2-b	JakB	TK	7k7q	A	B	6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-n-methylpyridazine-3-carboxamide	Human	13836	0.58
TYK2-b	JakB	TK	6nzp	B	A	6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide	Human	11496	0.90
TYK2-b	JakB	TK	6nzp	A	B	6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide	Human	11501	0.90
TYK2-b	JakB	TK	6nzh	A	A	6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide	Human	11450	0.40
TYK2-b	JakB	TK	6nzh	B	B	6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide	Human	11452	0.40
TYK2-b	JakB	TK	6nzp	B	B	6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide	Human	11497	0.90
TYK2-b	JakB	TK	6nzh	A	B	6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide	Human	11442	0.40
TYK2-b	JakB	TK	7k7q	A	A	6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-n-methylpyridazine-3-carboxamide	Human	13838	0.58
TYK2-b	JakB	TK	6nzh	B	A	6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide	Human	11447	0.40
TYK2-b	JakB	TK	7k7o	A	B	6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide	Human	13837	0.73
TYK2-b	JakB	TK	6nzp	A	A	6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide	Human	11504	0.90