| MAPK1 (Erk2) | MAPK | CMGC | 4xj0 | B | | 1-[(1s)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-(tetrahydro-2h-pyran-4-ylamino)pyrimidin-4-yl]pyridin-2(1h)-one | Human | 6049 | 0.40 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g9n | A | B | (2~{r})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(3-methylphenyl)-2-oxidanyl-ethyl]propanamide | Human | 11413 | 0.75 | |
| MAPK1 (Erk2) | MAPK | CMGC | 7nr5 | A | B | (2~{r})-2-[5-[5-chloranyl-2-[(2-methyl-1,2,3-triazol-4-yl)amino]pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(3-fluoranyl-5-methoxy-phenyl)-2-oxidanyl-ethyl]propanamide | Human | 13934 | 0.75 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g9j | A | A | 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{r})-1-phenylethyl]ethanamide | Human | 9952 | 0.55 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g9k | A | B | 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-2-oxidanyl-1-phenyl-ethyl]ethanamide | Human | 9947 | 0.59 | |
| MAPK1 (Erk2) | MAPK | CMGC | 7nr9 | A | A | (2~{r})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(2-methoxypyridin-4-yl)-2-oxidanyl-ethyl]propanamide | Human | 13932 | 0.78 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6ge0 | A | A | 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{r})-1-(3-methoxyphenyl)ethyl]ethanamide | Human | 9950 | 0.62 | |
| MAPK1 (Erk2) | MAPK | CMGC | 7nr8 | A | A | (2~{r})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-2-oxidanyl-ethyl]propanamide | Human | 13933 | 0.70 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g93 | A | A | 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2,3-dihydroisoindol-1-one | Human | 9955 | 0.49 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g9k | A | A | 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-2-oxidanyl-1-phenyl-ethyl]ethanamide | Human | 9966 | 0.59 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g9a | A | A | 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-(2-morpholin-4-ylethyl)-3~{h}-isoindol-1-one | Human | 11408 | 0.53 | |
| MAPK1 (Erk2) | MAPK | CMGC | 4o6e | A | A | n-[(1s)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-(tetrahydro-2h-pyran-4-ylamino)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6h)-carboxamide | Human | 2559 | 0.45 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g9h | A | B | ~{n}-~{tert}-butyl-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-methyl-ethanamide | Human | 9958 | 0.56 | |
| MAPK1 (Erk2) | MAPK | CMGC | 4o6e | A | B | n-[(1s)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-(tetrahydro-2h-pyran-4-ylamino)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6h)-carboxamide | Human | 2553 | 0.45 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g93 | A | B | 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2,3-dihydroisoindol-1-one | Human | 9959 | 0.49 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g97 | A | A | 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-(2-methoxyethyl)-3~{h}-isoindol-1-one | Human | 9960 | 0.56 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g9d | A | A | ~{n}-~{tert}-butyl-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]ethanamide | Human | 9972 | 0.54 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g9j | A | B | 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{r})-1-phenylethyl]ethanamide | Human | 9949 | 0.55 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g97 | A | B | 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-(2-methoxyethyl)-3~{h}-isoindol-1-one | Human | 9970 | 0.56 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6ge0 | A | B | 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{r})-1-(3-methoxyphenyl)ethyl]ethanamide | Human | 9961 | 0.62 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g9m | A | B | 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-(2-phenylpropan-2-yl)ethanamide | Human | 9944 | 0.54 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g9d | A | B | ~{n}-~{tert}-butyl-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]ethanamide | Human | 9953 | 0.54 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g9h | A | A | ~{n}-~{tert}-butyl-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-methyl-ethanamide | Human | 9971 | 0.56 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g9n | A | A | (2~{r})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(3-methylphenyl)-2-oxidanyl-ethyl]propanamide | Human | 11410 | 0.75 | |
| MAPK1 (Erk2) | MAPK | CMGC | 4xj0 | A | | 1-[(1s)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-(tetrahydro-2h-pyran-4-ylamino)pyrimidin-4-yl]pyridin-2(1h)-one | Human | 6048 | 0.40 | |
| MAPK1 (Erk2) | MAPK | CMGC | 7nr5 | A | A | (2~{r})-2-[5-[5-chloranyl-2-[(2-methyl-1,2,3-triazol-4-yl)amino]pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(3-fluoranyl-5-methoxy-phenyl)-2-oxidanyl-ethyl]propanamide | Human | 13921 | 0.75 | |
| MAPK1 (Erk2) | MAPK | CMGC | 7nr3 | A | B | 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-[2-oxidanylidene-2-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)ethyl]-3~{h}-isoindol-1-one | Human | 13922 | 0.52 | |
| MAPK1 (Erk2) | MAPK | CMGC | 7nr3 | A | A | 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-[2-oxidanylidene-2-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)ethyl]-3~{h}-isoindol-1-one | Human | 13923 | 0.52 | |
| MAPK1 (Erk2) | MAPK | CMGC | 7nqw | A | B | 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-[2-oxidanylidene-2-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)ethyl]-3~{h}-isoindol-1-one | Human | 13924 | 0.47 | |
| MAPK1 (Erk2) | MAPK | CMGC | 7nqq | A | B | 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(hydroxymethyl)-2,3-dihydroinden-1-yl]ethanamide | Human | 13928 | 0.48 | |
| MAPK1 (Erk2) | MAPK | CMGC | 7nr8 | A | B | (2~{r})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-2-oxidanyl-ethyl]propanamide | Human | 13929 | 0.70 | |
| MAPK1 (Erk2) | MAPK | CMGC | 7nqw | A | A | 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-[2-oxidanylidene-2-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)ethyl]-3~{h}-isoindol-1-one | Human | 13927 | 0.47 | |
| MAPK1 (Erk2) | MAPK | CMGC | 7auv | A | B | (2~{r})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(3-fluoranyl-5-methoxy-phenyl)-2-oxidanyl-ethyl]propanamide | Human | 13930 | 1.00 | |
| MAPK1 (Erk2) | MAPK | CMGC | 7nr9 | A | B | (2~{r})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(2-methoxypyridin-4-yl)-2-oxidanyl-ethyl]propanamide | Human | 13931 | 0.78 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g9a | A | B | 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-(2-morpholin-4-ylethyl)-3~{h}-isoindol-1-one | Human | 11412 | 0.53 | |
| MAPK1 (Erk2) | MAPK | CMGC | 7auv | A | A | (2~{r})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(3-fluoranyl-5-methoxy-phenyl)-2-oxidanyl-ethyl]propanamide | Human | 13925 | 1.00 | |
| MAPK1 (Erk2) | MAPK | CMGC | 7nqq | A | A | 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(hydroxymethyl)-2,3-dihydroinden-1-yl]ethanamide | Human | 13926 | 0.48 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g9m | A | A | 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-(2-phenylpropan-2-yl)ethanamide | Human | 9964 | 0.54 | |
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