Searching for structures with analogs of -.

Search results (38 entries covering 19 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
MAPK1 (Erk2)MAPKCMGC6ge0AB2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{r})-1-(3-methoxyphenyl)ethyl]ethanamideHuman99610.62
MAPK1 (Erk2)MAPKCMGC6g9mAB2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-(2-phenylpropan-2-yl)ethanamideHuman99440.54
MAPK1 (Erk2)MAPKCMGC6g9hAA~{n}-~{tert}-butyl-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-methyl-ethanamideHuman99710.56
MAPK1 (Erk2)MAPKCMGC6g9hAB~{n}-~{tert}-butyl-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-methyl-ethanamideHuman99580.56
MAPK1 (Erk2)MAPKCMGC6g9dAB~{n}-~{tert}-butyl-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]ethanamideHuman99530.54
MAPK1 (Erk2)MAPKCMGC6g9kAA2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-2-oxidanyl-1-phenyl-ethyl]ethanamideHuman99660.59
MAPK1 (Erk2)MAPKCMGC6g9nAA(2~{r})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(3-methylphenyl)-2-oxidanyl-ethyl]propanamideHuman114100.75
MAPK1 (Erk2)MAPKCMGC6g9kAB2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-2-oxidanyl-1-phenyl-ethyl]ethanamideHuman99470.59
MAPK1 (Erk2)MAPKCMGC6g9jAA2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{r})-1-phenylethyl]ethanamideHuman99520.55
MAPK1 (Erk2)MAPKCMGC6g97AB6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-(2-methoxyethyl)-3~{h}-isoindol-1-oneHuman99700.56
MAPK1 (Erk2)MAPKCMGC4xj0B1-[(1s)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-(tetrahydro-2h-pyran-4-ylamino)pyrimidin-4-yl]pyridin-2(1h)-oneHuman60490.40
MAPK1 (Erk2)MAPKCMGC7nr9AA(2~{r})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(2-methoxypyridin-4-yl)-2-oxidanyl-ethyl]propanamideHuman139320.78
MAPK1 (Erk2)MAPKCMGC6ge0AA2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{r})-1-(3-methoxyphenyl)ethyl]ethanamideHuman99500.62
MAPK1 (Erk2)MAPKCMGC7nr8AA(2~{r})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-2-oxidanyl-ethyl]propanamideHuman139330.70
MAPK1 (Erk2)MAPKCMGC7nr5AB(2~{r})-2-[5-[5-chloranyl-2-[(2-methyl-1,2,3-triazol-4-yl)amino]pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(3-fluoranyl-5-methoxy-phenyl)-2-oxidanyl-ethyl]propanamideHuman139340.75
MAPK1 (Erk2)MAPKCMGC4o6eABn-[(1s)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-(tetrahydro-2h-pyran-4-ylamino)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6h)-carboxamideHuman25530.45
MAPK1 (Erk2)MAPKCMGC6g93AA6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2,3-dihydroisoindol-1-oneHuman99550.49
MAPK1 (Erk2)MAPKCMGC4o6eAAn-[(1s)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-(tetrahydro-2h-pyran-4-ylamino)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6h)-carboxamideHuman25590.45
MAPK1 (Erk2)MAPKCMGC4xj0A1-[(1s)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-(tetrahydro-2h-pyran-4-ylamino)pyrimidin-4-yl]pyridin-2(1h)-oneHuman60480.40
MAPK1 (Erk2)MAPKCMGC6g9nAB(2~{r})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(3-methylphenyl)-2-oxidanyl-ethyl]propanamideHuman114130.75
MAPK1 (Erk2)MAPKCMGC6g9aAA6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-(2-morpholin-4-ylethyl)-3~{h}-isoindol-1-oneHuman114080.53
MAPK1 (Erk2)MAPKCMGC6g93AB6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2,3-dihydroisoindol-1-oneHuman99590.49
MAPK1 (Erk2)MAPKCMGC6g97AA6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-(2-methoxyethyl)-3~{h}-isoindol-1-oneHuman99600.56
MAPK1 (Erk2)MAPKCMGC6g9dAA~{n}-~{tert}-butyl-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]ethanamideHuman99720.54
MAPK1 (Erk2)MAPKCMGC6g9jAB2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{r})-1-phenylethyl]ethanamideHuman99490.55
MAPK1 (Erk2)MAPKCMGC7nr3AB6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-[2-oxidanylidene-2-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)ethyl]-3~{h}-isoindol-1-oneHuman139220.52
MAPK1 (Erk2)MAPKCMGC7nr5AA(2~{r})-2-[5-[5-chloranyl-2-[(2-methyl-1,2,3-triazol-4-yl)amino]pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(3-fluoranyl-5-methoxy-phenyl)-2-oxidanyl-ethyl]propanamideHuman139210.75
MAPK1 (Erk2)MAPKCMGC7nr3AA6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-[2-oxidanylidene-2-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)ethyl]-3~{h}-isoindol-1-oneHuman139230.52
MAPK1 (Erk2)MAPKCMGC7nr9AB(2~{r})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(2-methoxypyridin-4-yl)-2-oxidanyl-ethyl]propanamideHuman139310.78
MAPK1 (Erk2)MAPKCMGC7nqwAA6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-[2-oxidanylidene-2-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)ethyl]-3~{h}-isoindol-1-oneHuman139270.47
MAPK1 (Erk2)MAPKCMGC7nqwAB6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-[2-oxidanylidene-2-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)ethyl]-3~{h}-isoindol-1-oneHuman139240.47
MAPK1 (Erk2)MAPKCMGC7nqqAB2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(hydroxymethyl)-2,3-dihydroinden-1-yl]ethanamideHuman139280.48
MAPK1 (Erk2)MAPKCMGC7nr8AB(2~{r})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-2-oxidanyl-ethyl]propanamideHuman139290.70
MAPK1 (Erk2)MAPKCMGC7auvAB(2~{r})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(3-fluoranyl-5-methoxy-phenyl)-2-oxidanyl-ethyl]propanamideHuman139301.00
MAPK1 (Erk2)MAPKCMGC6g9aAB6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-(2-morpholin-4-ylethyl)-3~{h}-isoindol-1-oneHuman114120.53
MAPK1 (Erk2)MAPKCMGC7auvAA(2~{r})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(3-fluoranyl-5-methoxy-phenyl)-2-oxidanyl-ethyl]propanamideHuman139251.00
MAPK1 (Erk2)MAPKCMGC7nqqAA2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-[(1~{s})-1-(hydroxymethyl)-2,3-dihydroinden-1-yl]ethanamideHuman139260.48
MAPK1 (Erk2)MAPKCMGC6g9mAA2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{h}-isoindol-2-yl]-~{n}-(2-phenylpropan-2-yl)ethanamideHuman99640.54