| BTK | Tec | TK | 4yhf | A | A | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2916 | 0.40 | |
| EGFR | EGFR | TK | 5yu9 | D | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9431 | 0.52 | |
| EGFR | EGFR | TK | 5yu9 | A | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9430 | 0.52 | |
| BTK | Tec | TK | 6omu | A | A | 1-[4-({[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino}methyl)piperidin-1-yl]prop-2-en-1-one | Human | 11529 | 1.00 | |
| EGFR | EGFR | TK | 5yu9 | C | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9432 | 0.52 | |
| BTK | Tec | TK | 5p9i | A | C | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 7638 | 0.52 | |
| EGFR | EGFR | TK | 5yu9 | C | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9427 | 0.52 | |
| BTK | Tec | TK | 5p9m | A | A | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Human | 7634 | 0.43 | |
| BTK | Tec | TK | 6omu | A | B | 1-[4-({[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino}methyl)piperidin-1-yl]prop-2-en-1-one | Human | 11530 | 1.00 | |
| EGFR | EGFR | TK | 5yu9 | D | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9429 | 0.52 | |
| EGFR | EGFR | TK | 5yu9 | B | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9433 | 0.52 | |
| Btk (BTK) | Tec | TK | 8ff0 | A | | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Mouse | 14834 | 0.43 | |
| MAP2K7 | STE7 | STE | 6yg2 | A | B | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 12686 | 0.42 | |
| EGFR | EGFR | TK | 5yu9 | B | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9434 | 0.52 | |
| HCK | Src | TK | 5h0g | A | | (2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{n},4-dimethyl-pentanamide | Human | 8536 | 0.40 | |
| MAP2K7 | STE7 | STE | 6yg2 | A | A | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 12678 | 0.42 | |
| HCK | Src | TK | 3vs4 | A | | 5-(4-phenoxyphenyl)-7-(tetrahydro-2h-pyran-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2654 | 0.40 | |
| HCK | Src | TK | 3vs5 | B | | 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2669 | 0.40 | |
| HCK | Src | TK | 3vs5 | A | | 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2645 | 0.40 | |
| HCK | Src | TK | 5h09 | A | | ethyl (2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanoate | Human | 8537 | 0.40 | |
| HCK | Src | TK | 3vry | A | | 4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | Human | 2647 | 0.41 | |
| HCK | Src | TK | 5h0e | A | | (2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanamide | Human | 8538 | 0.42 | |
| HCK | Src | TK | 3vry | B | | 4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | Human | 2646 | 0.41 | |
| HCK | Src | TK | 3vs4 | B | | 5-(4-phenoxyphenyl)-7-(tetrahydro-2h-pyran-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2638 | 0.40 | |
| EGFR | EGFR | TK | 5yu9 | A | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9428 | 0.52 | |
| BTK | Tec | TK | 5p9j | A | B | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 7628 | 0.42 | |
| BTK | Tec | TK | 5p9i | A | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 7627 | 0.52 | |
| BTK | Tec | TK | 3gen | A | B | 4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | Human | 2900 | 0.41 | |
| BTK | Tec | TK | 6di3 | A | | 6-[(3s)-3-(acryloylamino)pyrrolidin-1-yl]-2-(4-phenoxyphenoxy)pyridine-3-carboxamide | Human | 10474 | 0.42 | |
| BTK | Tec | TK | 4yhf | B | B | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2912 | 0.40 | |
| BTK | Tec | TK | 5p9m | A | B | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Human | 7639 | 0.43 | |
| BTK | Tec | TK | 3gen | A | A | 4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | Human | 2928 | 0.41 | |
| BTK | Tec | TK | 4yhf | B | A | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2897 | 0.40 | |
| BTK | Tec | TK | 5p9j | A | C | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 7640 | 0.42 | |
| BTK | Tec | TK | 5p9j | A | A | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 7637 | 0.42 | |
| BTK | Tec | TK | 5p9i | A | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 7642 | 0.52 | |
| BTK | Tec | TK | 5p9m | A | C | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Human | 7641 | 0.43 | |
| BTK | Tec | TK | 4yhf | A | B | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2902 | 0.40 | |
Match: