KLIFS - the structural kinase database

Searching for structures with analogs of Fisogatinib.

Search results (13 entries covering 6 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
FGFR4	FGFR	TK	4xcu	A	A	n-(2-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}-3-methylphenyl)prop-2-enamide	Human	928	0.60
FGFR4	FGFR	TK	6v9c	A	A	n-[(3r,4s)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide	Human	12096	0.61
FGFR4	FGFR	TK	6nvk	A	B	n-[(3s,4s)-3-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}oxan-4-yl]propanamide	Human	11390	0.78
FGFR4	FGFR	TK	6nvk	A	A	n-[(3s,4s)-3-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}oxan-4-yl]propanamide	Human	11395	0.78
FGFR4	FGFR	TK	4xcu	A	B	n-(2-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}-3-methylphenyl)prop-2-enamide	Human	924	0.60
FGFR4	FGFR	TK	6v9c	A	B	n-[(3r,4s)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide	Human	12095	0.61
FGFR4	FGFR	TK	7f3m	A		6-[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one	Human	14034	0.41
SYK	Syk	TK	3srv	A	B	2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide	Human	1162	0.43
SYK	Syk	TK	3srv	A	A	2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide	Human	1154	0.43
SYK	Syk	TK	3srv	B	B	2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide	Human	1206	0.43
SYK	Syk	TK	3srv	B	A	2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide	Human	1181	0.43
EIF2AK3 (PEK)	PEK	Other	4x7j	A	A	2-amino-n-[4-methoxy-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-(methylamino)quinazolin-6-yl]benzamide	Human	6848	0.41
EIF2AK3 (PEK)	PEK	Other	4x7j	A	B	2-amino-n-[4-methoxy-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-(methylamino)quinazolin-6-yl]benzamide	Human	6841	0.41