KLIFS - the structural kinase database

Searching for structures with analogs of Fadraciclib.

Search results (44 entries covering 27 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
CDK2	CDK	CMGC	3ddq	C	A	r-roscovitine	Human	4364	0.51
CDK2	CDK	CMGC	5mhq	A	B	(2~{r},3~{s})-3-[[9-propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]pentan-2-ol	Human	9408	0.64
CDK2	CDK	CMGC	3ddp	C	B	(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-ol	Human	6778	0.45
CDK2	CDK	CMGC	3ddq	A	A	r-roscovitine	Human	4477	0.51
CDK2	CDK	CMGC	2a0c	X	A	2-{[(2-{[(1r)-1-(hydroxymethyl)propyl]amino}-9-isopropyl-9h-purin-6-yl)amino]methyl}phenol	Human	4157	0.56
CDK2	CDK	CMGC	3ddq	C	B	r-roscovitine	Human	4289	0.51
RPS6KA1 (RSK3)	RSK	AGC	2z7s	A		2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-ol	Human	2776	0.44
CDK5	CDK	CMGC	1unl	A		r-roscovitine	Human	2785	0.51
CDK2	CDK	CMGC	2a4l	A		r-roscovitine	Human	4238	0.51
CDK2	CDK	CMGC	3ddp	A	B	(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-ol	Human	6780	0.45
ABL1	Abl	TK	6bl8	A	A	purvalanol b	Human	9699	0.41
CDK2	CDK	CMGC	8fp0	A	B	r-roscovitine	Human	14756	0.51
CDK2	CDK	CMGC	8fp0	A	A	r-roscovitine	Human	14758	0.51
CSNK1G3 (CK1g3)	CK1	CK1	2izu	A	B	2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-ol	Human	2225	0.44
CDK6	CDK	CMGC	2f2c	B		(2s)-2-({6-[(3-amino-5-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-ol	Human	2795	0.44
SRPK2	SRPK	CMGC	2x7g	A		purvalanol b	Human	1409	0.41
ABL1	Abl	TK	6bl8	B	A	purvalanol b	Human	9701	0.41
ABL1	Abl	TK	6bl8	B	B	purvalanol b	Human	9700	0.41
ABL1	Abl	TK	6bl8	A	B	purvalanol b	Human	9698	0.41
SRC	Src	TK	1yom	A		2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-ol	Human	973	0.44
SRC	Src	TK	1yom	B		2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-ol	Human	987	0.44
CDK12 (CRK7)	CDK	CMGC	8bul	B		(2~{r})-2-[[6-(3-phenylpropylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol	Human	14911	0.46
CDK12 (CRK7)	CDK	CMGC	6td3	E		(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-ol	Human	12369	0.45
CDK12 (CRK7)	CDK	CMGC	8bu9	B		r-roscovitine	Human	14914	0.51
CDK12 (CRK7)	CDK	CMGC	8buq	B		(2~{r})-2-[[6-[[1-(3-chlorophenyl)pyrazol-3-yl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol	Human	14917	0.47
CDK12 (CRK7)	CDK	CMGC	6td3	H		(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-ol	Human	12370	0.45
CDK12 (CRK7)	CDK	CMGC	6td3	B		(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-ol	Human	12371	0.45
CDK12 (CRK7)	CDK	CMGC	8buh	B		6-[[[2-[[(2~{r})-1-oxidanylbutan-2-yl]amino]-9-propan-2-yl-purin-6-yl]amino]methyl]-3-pyridin-2-yl-1~{h}-pyridin-2-one	Human	14922	0.44
CDK12 (CRK7)	CDK	CMGC	8bup	B		(2~{r})-2-[[6-[3-(3-methylphenyl)propylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol	Human	14923	0.47
CDK12 (CRK7)	CDK	CMGC	8bum	B		(2r)-2-[[6-(5-naphthalen-1-ylpentylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol	Human	14924	0.45
CDK12 (CRK7)	CDK	CMGC	8buk	B		(2~{r})-2-[[6-(naphthalen-2-ylmethylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol	Human	14927	0.50
CDK12 (CRK7)	CDK	CMGC	8buj	B		(2~{r})-2-[[6-(octylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol	Human	14933	0.52
CDK12 (CRK7)	CDK	CMGC	8buo	B		(2~{r})-2-[[6-[(3-fluoranyl-4-pyridin-2-yl-phenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol	Human	14934	0.45
CDK12 (CRK7)	CDK	CMGC	8but	B		2-[[6-[[4-(2-hydroxyethyloxy)phenyl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol	Human	14936	0.47
CDK2	CDK	CMGC	1ckp	A	A	purvalanol b	Human	4066	0.41
CDK2	CDK	CMGC	2a0c	X	B	2-{[(2-{[(1r)-1-(hydroxymethyl)propyl]amino}-9-isopropyl-9h-purin-6-yl)amino]methyl}phenol	Human	3868	0.56
CDK2	CDK	CMGC	1ckp	A	B	purvalanol b	Human	4214	0.41
CDK2	CDK	CMGC	3ddq	A	B	r-roscovitine	Human	4269	0.51
CDK2	CDK	CMGC	5mhq	A	A	(2~{r},3~{s})-3-[[9-propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]pentan-2-ol	Human	9409	0.64
CDK2	CDK	CMGC	3ddp	A	A	(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-ol	Human	6781	0.45
CDK2	CDK	CMGC	3ddp	C	A	(2r)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-ol	Human	6784	0.45
CDK9	CDK	CMGC	3lq5	A		(2s)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9h-purin-2-yl}amino)butan-1-ol	Human	2253	0.45
CSNK1G3 (CK1g3)	CK1	CK1	2izu	A	A	2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-ol	Human	2218	0.44
CDK12 (CRK7)	CDK	CMGC	8bun	B		(2~{r})-2-[[6-[(4-phenylphenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol	Human	14916	0.49