| MET | Met | TK | 5hor | A | | 1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea | Human | 7276 | 1.00 | |
| CDK8 | CDK | CMGC | 4f70 | A | | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[2-(morpholin-4-yl)ethyl]urea | Human | 3852 | 0.40 | |
| DYRK1A | DYRK | CMGC | 6eij | B | | ~{n}-[5-[3-(2-morpholin-4-ylethylcarbamoylamino)phenyl]-[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide | Human | 10516 | 0.48 | |
| DYRK1A | DYRK | CMGC | 6eij | C | | ~{n}-[5-[3-(2-morpholin-4-ylethylcarbamoylamino)phenyl]-[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide | Human | 10538 | 0.48 | |
| DYRK1A | DYRK | CMGC | 6eij | A | | ~{n}-[5-[3-(2-morpholin-4-ylethylcarbamoylamino)phenyl]-[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide | Human | 10518 | 0.48 | |
| DYRK1A | DYRK | CMGC | 6eij | D | | ~{n}-[5-[3-(2-morpholin-4-ylethylcarbamoylamino)phenyl]-[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide | Human | 10559 | 0.48 | |
| MAP3K8 (COT) | STE-Unique | STE | 5iu2 | A | A | n-[2-(morpholin-4-yl)ethyl]-6-(8-phenyl-1h-imidazo[4,5-c][1,7]naphthyridin-1-yl)-1,3-benzothiazol-2-amine | Human | 6980 | 0.41 | |
| MAP3K8 (COT) | STE-Unique | STE | 5iu2 | B | B | n-[2-(morpholin-4-yl)ethyl]-6-(8-phenyl-1h-imidazo[4,5-c][1,7]naphthyridin-1-yl)-1,3-benzothiazol-2-amine | Human | 6978 | 0.41 | |
| MAP3K8 (COT) | STE-Unique | STE | 5iu2 | A | B | n-[2-(morpholin-4-yl)ethyl]-6-(8-phenyl-1h-imidazo[4,5-c][1,7]naphthyridin-1-yl)-1,3-benzothiazol-2-amine | Human | 6981 | 0.41 | |
| MAP3K8 (COT) | STE-Unique | STE | 5iu2 | B | A | n-[2-(morpholin-4-yl)ethyl]-6-(8-phenyl-1h-imidazo[4,5-c][1,7]naphthyridin-1-yl)-1,3-benzothiazol-2-amine | Human | 6979 | 0.41 | |
| MET | Met | TK | 5hni | X | | methyl (6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1h-benzimidazol-2-yl)carbamate | Human | 7280 | 0.53 | |
| MET | Met | TK | 5hni | Y | | methyl (6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1h-benzimidazol-2-yl)carbamate | Human | 7278 | 0.53 | |
| MET | Met | TK | 5hoa | A | | 1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea | Human | 7279 | 1.00 | |
| MET | Met | TK | 5hlw | A | | 1-[2-(1-ethylpiperidin-4-yl)ethyl]-3-(6-{[6-(thiophen-2-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)urea | Human | 7275 | 0.58 | |
| MET | Met | TK | 5ho6 | A | | 1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea | Human | 7277 | 1.00 | |