KLIFS - the structural kinase database

Searching for structures with analogs of -.

Search results (15 entries covering 8 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
MET	Met	TK	5hor	A		1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea	Human	7276	1.00
CDK8	CDK	CMGC	4f70	A		1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[2-(morpholin-4-yl)ethyl]urea	Human	3852	0.40
DYRK1A	DYRK	CMGC	6eij	B		~{n}-[5-[3-(2-morpholin-4-ylethylcarbamoylamino)phenyl]-[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide	Human	10516	0.48
DYRK1A	DYRK	CMGC	6eij	C		~{n}-[5-[3-(2-morpholin-4-ylethylcarbamoylamino)phenyl]-[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide	Human	10538	0.48
DYRK1A	DYRK	CMGC	6eij	A		~{n}-[5-[3-(2-morpholin-4-ylethylcarbamoylamino)phenyl]-[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide	Human	10518	0.48
DYRK1A	DYRK	CMGC	6eij	D		~{n}-[5-[3-(2-morpholin-4-ylethylcarbamoylamino)phenyl]-[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide	Human	10559	0.48
MAP3K8 (COT)	STE-Unique	STE	5iu2	A	A	n-[2-(morpholin-4-yl)ethyl]-6-(8-phenyl-1h-imidazo[4,5-c][1,7]naphthyridin-1-yl)-1,3-benzothiazol-2-amine	Human	6980	0.41
MAP3K8 (COT)	STE-Unique	STE	5iu2	B	B	n-[2-(morpholin-4-yl)ethyl]-6-(8-phenyl-1h-imidazo[4,5-c][1,7]naphthyridin-1-yl)-1,3-benzothiazol-2-amine	Human	6978	0.41
MAP3K8 (COT)	STE-Unique	STE	5iu2	A	B	n-[2-(morpholin-4-yl)ethyl]-6-(8-phenyl-1h-imidazo[4,5-c][1,7]naphthyridin-1-yl)-1,3-benzothiazol-2-amine	Human	6981	0.41
MAP3K8 (COT)	STE-Unique	STE	5iu2	B	A	n-[2-(morpholin-4-yl)ethyl]-6-(8-phenyl-1h-imidazo[4,5-c][1,7]naphthyridin-1-yl)-1,3-benzothiazol-2-amine	Human	6979	0.41
MET	Met	TK	5hni	X		methyl (6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1h-benzimidazol-2-yl)carbamate	Human	7280	0.53
MET	Met	TK	5hni	Y		methyl (6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1h-benzimidazol-2-yl)carbamate	Human	7278	0.53
MET	Met	TK	5hoa	A		1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea	Human	7279	1.00
MET	Met	TK	5hlw	A		1-[2-(1-ethylpiperidin-4-yl)ethyl]-3-(6-{[6-(thiophen-2-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)urea	Human	7275	0.58
MET	Met	TK	5ho6	A		1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea	Human	7277	1.00