KLIFS - the structural kinase database

Searching for structures with analogs of -.

Search results (18 entries covering 8 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
PIM1	PIM	CAMK	2c3i	B	A	1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl}phenyl)ethanone	Human	2348	0.60
NTRK3 (TRKC)	Trk	TK	4ymj	B	A	4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile	Human	100	0.40
PIM1	PIM	CAMK	2c3i	B	B	1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl}phenyl)ethanone	Human	2374	0.60
PIM1	PIM	CAMK	4a7c	A		n-(piperidin-4-ylmethyl)-3-[3-(trifluoromethyloxy)phenyl]-[1,2,3]triazolo[4,5-b]pyridin-5-amine	Human	2321	0.40
CLK1	CLK	CMGC	6yta	A	B	1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl}phenyl)ethanone	Human	12417	0.60
DYRK1A	DYRK	CMGC	6s11	A	A	6-pyridin-4-yl-3-[3-(trifluoromethyloxy)phenyl]imidazo[1,2-b]pyridazine	Human	11361	0.54
DYRK1A	DYRK	CMGC	6s11	B	B	6-pyridin-4-yl-3-[3-(trifluoromethyloxy)phenyl]imidazo[1,2-b]pyridazine	Human	11372	0.54
DYRK1A	DYRK	CMGC	6s11	B	A	6-pyridin-4-yl-3-[3-(trifluoromethyloxy)phenyl]imidazo[1,2-b]pyridazine	Human	11378	0.54
DYRK1A	DYRK	CMGC	6s11	A	B	6-pyridin-4-yl-3-[3-(trifluoromethyloxy)phenyl]imidazo[1,2-b]pyridazine	Human	11364	0.54
ACVR1 (ALK2)	STKR	TKL	4dym	A		1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl}phenyl)ethanone	Human	1509	0.60
ACVR1 (ALK2)	STKR	TKL	3oom	A	A	1-{3-[6-(tetrahydro-2h-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone	Human	1517	0.42
ACVR1 (ALK2)	STKR	TKL	3oom	A	B	1-{3-[6-(tetrahydro-2h-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone	Human	1518	0.42
HASPIN (Haspin)	Haspin	Other	3f2n	A	B	(2s)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol	Human	3813	0.40
HASPIN (Haspin)	Haspin	Other	3f2n	A	A	(2s)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol	Human	3803	0.40
NTRK3 (TRKC)	Trk	TK	4ymj	A	A	4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile	Human	101	0.40
NTRK3 (TRKC)	Trk	TK	4ymj	A	B	4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile	Human	98	0.40
NTRK3 (TRKC)	Trk	TK	4ymj	B	B	4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile	Human	99	0.40
CLK1	CLK	CMGC	6yta	A	A	1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl}phenyl)ethanone	Human	12423	0.60