| IRAK4 | IRAK | TKL | 6ega | B | B | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-n-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10910 | 0.42 | |
| IRAK4 | IRAK | TKL | 6eg9 | A | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10905 | 0.67 | |
| Abl1 (ABL1) | Abl | TK | 3oy3 | A | | 5-[(5-{[4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-3-(trifluoromethyl)phenyl]carbamoyl}-2-methylphenyl)ethynyl]-1-methyl-1h-imidazole-2-carboxamide | Mouse | 5711 | 0.66 | |
| Abl1 (ABL1) | Abl | TK | 3ik3 | B | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Mouse | 5739 | 0.67 | |
| Abl1 (ABL1) | Abl | TK | 3oy3 | B | | 5-[(5-{[4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-3-(trifluoromethyl)phenyl]carbamoyl}-2-methylphenyl)ethynyl]-1-methyl-1h-imidazole-2-carboxamide | Mouse | 5738 | 0.66 | |
| BRAF | RAF | TKL | 6p3d | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 12809 | 0.67 | |
| FGFR4 | FGFR | TK | 4uxq | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 930 | 0.67 | |
| FGFR4 | FGFR | TK | 4qrc | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 923 | 0.67 | |
| MAP2K7 | STE7 | STE | 6yg7 | B | A | ~{n}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{r})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamide | Human | 12696 | 0.47 | |
| BRAF | RAF | TKL | 6p7g | C | | 3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-n-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide | Human | 12807 | 0.53 | |
| RIPK2 | RIPK | TKL | 4c8b | B | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 1253 | 0.67 | |
| BRAF | RAF | TKL | 6p7g | B | | 3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-n-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide | Human | 12806 | 0.53 | |
| DDR1 | DDR | TK | 3zos | B | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3258 | 0.67 | |
| DDR1 | DDR | TK | 3zos | B | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3260 | 0.67 | |
| CDK2 | CDK | CMGC | 5a14 | A | B | 1-[4-(2-azanylpyrimidin-4-yl)oxyphenyl]-3-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]urea | Human | 3901 | 0.45 | |
| DDR1 | DDR | TK | 3zos | A | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3253 | 0.67 | |
| MAP2K7 | STE7 | STE | 6yg7 | B | B | ~{n}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{r})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamide | Human | 12685 | 0.47 | |
| BRAF | RAF | TKL | 6p7g | A | | 3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-n-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide | Human | 12810 | 0.53 | |
| DDR1 | DDR | TK | 6gwr | B | B | 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{n}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide | Human | 10487 | 0.42 | |
| MAP2K7 | STE7 | STE | 6yg6 | B | A | ~{n}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{s})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamide | Human | 12673 | 0.47 | |
| BRAF | RAF | TKL | 6p7g | D | | 3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-n-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide | Human | 12808 | 0.53 | |
| CDK2 | CDK | CMGC | 5a14 | A | A | 1-[4-(2-azanylpyrimidin-4-yl)oxyphenyl]-3-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]urea | Human | 3977 | 0.45 | |
| MAP2K7 | STE7 | STE | 6yg7 | A | A | ~{n}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{r})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamide | Human | 12683 | 0.47 | |
| MAP2K7 | STE7 | STE | 6yg6 | A | B | ~{n}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{s})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamide | Human | 12687 | 0.47 | |
| IRAK4 | IRAK | TKL | 6eg9 | B | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10909 | 0.67 | |
| IRAK4 | IRAK | TKL | 6ega | B | A | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-n-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10912 | 0.42 | |
| EPHA2 (EphA2) | Eph | TK | 8boi | A | B | 4-methyl-~{n}-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14655 | 0.51 | |
| IRAK4 | IRAK | TKL | 6eg9 | B | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10911 | 0.67 | |
| FGFR4 | FGFR | TK | 4tyj | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 925 | 0.67 | |
| EPHA2 (EphA2) | Eph | TK | 8boi | A | A | 4-methyl-~{n}-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14645 | 0.51 | |
| FGR | Src | TK | 7uy3 | A | | 3-[(6,7-dimethoxyquinazolin-4-yl)oxy]-n-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methylbenzamide | Human | 14567 | 0.52 | |
| MAP2K7 | STE7 | STE | 6yg7 | A | B | ~{n}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{r})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamide | Human | 12674 | 0.47 | |
| MAP2K7 | STE7 | STE | 6yg6 | B | B | ~{n}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{s})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamide | Human | 12694 | 0.47 | |
| RIPK2 | RIPK | TKL | 4c8b | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 1254 | 0.67 | |
| DDR1 | DDR | TK | 4ckr | A | A | 4-[(4-ethylpiperazin-1-yl)methyl]-n-{4-methyl-3-[(2-oxo-2,3-dihydro-1h-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide | Human | 3257 | 0.49 | |
| DDR1 | DDR | TK | 6gwr | B | A | 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{n}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide | Human | 10486 | 0.42 | |
| DDR1 | DDR | TK | 6gwr | A | B | 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{n}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide | Human | 10484 | 0.42 | |
| DDR1 | DDR | TK | 6gwr | A | A | 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{n}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide | Human | 10485 | 0.42 | |
| DDR1 | DDR | TK | 3zos | A | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3262 | 0.67 | |
| DDR1 | DDR | TK | 4ckr | A | B | 4-[(4-ethylpiperazin-1-yl)methyl]-n-{4-methyl-3-[(2-oxo-2,3-dihydro-1h-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide | Human | 3252 | 0.49 | |
| MAP3K7 (TAK1) | MLK | TKL | 4o91 | A | | n-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methyl-3-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide | Human | 1888 | 0.53 | |
| ABL1 | Abl | TK | 5hu9 | A | B | 4-[(4-methylpiperazin-1-yl)methyl]-n-(4-methyl-3-{[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]oxy}phenyl)-3-(trifluoromethyl)benzamide | Human | 6755 | 0.52 | |
| ABL1 | Abl | TK | 5hu9 | A | A | 4-[(4-methylpiperazin-1-yl)methyl]-n-(4-methyl-3-{[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]oxy}phenyl)-3-(trifluoromethyl)benzamide | Human | 6754 | 0.52 | |
| ABL1 | Abl | TK | 2e2b | A | | n-[3-(4,5'-bipyrimidin-2-ylamino)-4-methylphenyl]-4-{[(3s)-3-(dimethylamino)pyrrolidin-1-yl]methyl}-3-(trifluoromethyl)benzamide | Human | 1054 | 0.46 | |
| JAK2 | JakA | TK | 7rn6 | A | B | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide | Human | 13955 | 0.43 | |
| JAK2 | JakA | TK | 3ugc | A | B | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide | Human | 3651 | 0.43 | |
| JAK2 | JakA | TK | 3ugc | A | A | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide | Human | 3632 | 0.43 | |
| JAK2 | JakA | TK | 7rn6 | A | A | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide | Human | 13956 | 0.43 | |
| SRC | Src | TK | 7ote | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 14240 | 0.67 | |
| FGFR1 | FGFR | TK | 4v01 | A | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3556 | 0.67 | |
| FGFR1 | FGFR | TK | 4v01 | A | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3590 | 0.67 | |
| FGFR1 | FGFR | TK | 4v04 | A | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3542 | 0.67 | |
| FGFR1 | FGFR | TK | 4v01 | B | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3497 | 0.67 | |
| FGFR1 | FGFR | TK | 4v04 | B | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3524 | 0.67 | |
| FGFR1 | FGFR | TK | 4v01 | B | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3594 | 0.67 | |
| KIT | PDGFR | TK | 4u0i | A | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 405 | 0.67 | |
| KIT | PDGFR | TK | 4u0i | A | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 396 | 0.67 | |
| LRRK2 | LRRK | TKL | 8tze | A | | 4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1h-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide | Human | 15054 | 1.00 | |
| LRRK2 | LRRK | TKL | 8tyq | A | B | 4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1h-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide | Human | 15055 | 1.00 | |
| LRRK2 | LRRK | TKL | 8tyq | A | A | 4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1h-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide | Human | 15058 | 1.00 | |
| ROR1 | Ror | TK | 6tu9 | B | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 11945 | 0.67 | |
| ROR1 | Ror | TK | 6tu9 | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 11944 | 0.67 | |
| IRAK4 | IRAK | TKL | 6ega | A | B | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-n-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10907 | 0.42 | |
| IRAK4 | IRAK | TKL | 6eg9 | A | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10906 | 0.67 | |
| IRAK4 | IRAK | TKL | 6ega | A | A | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-n-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10908 | 0.42 | |
| Abl1 (ABL1) | Abl | TK | 3ik3 | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Mouse | 5731 | 0.67 | |
| Abl1 (ABL1) | Abl | TK | 3oxz | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Mouse | 5721 | 0.67 | |
| MAP2K7 | STE7 | STE | 6yg6 | A | A | ~{n}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{s})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamide | Human | 12676 | 0.47 | |
| ABL1 | Abl | TK | 2e2b | B | | n-[3-(4,5'-bipyrimidin-2-ylamino)-4-methylphenyl]-4-{[(3s)-3-(dimethylamino)pyrrolidin-1-yl]methyl}-3-(trifluoromethyl)benzamide | Human | 1065 | 0.46 | |
Match: