Searching for structures with analogs of Pexmetinib.
Search results (38 entries covering 26 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | Similarity (MFP) | File |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EPHA3 (EphA3) | Eph | TK | 4twn | A | B | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 2865 | 0.42 | ||
| CDK8 | CDK | CMGC | 4f7j | A | A | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(2-hydroxyethyl)urea | Human | 3842 | 0.52 | ||
| STK10 (LOK) | STE20 | STE | 6gtt | A | A | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 10026 | 0.42 | ||
| MAPK11 (p38b) | MAPK | CMGC | 8ygw | A | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 15234 | 0.42 | |||
| CDK8 | CDK | CMGC | 4f70 | A | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[2-(morpholin-4-yl)ethyl]urea | Human | 3852 | 0.47 | |||
| BRAF | RAF | TKL | 4jvg | A | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 3134 | 0.42 | |||
| BRAF | RAF | TKL | 4jvg | B | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 3085 | 0.42 | |||
| CDK8 | CDK | CMGC | 4f6u | A | A | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(morpholin-4-yl)propyl]urea | Human | 3849 | 0.46 | ||
| CDK8 | CDK | CMGC | 4f7j | A | B | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(2-hydroxyethyl)urea | Human | 3843 | 0.52 | ||
| CDK8 | CDK | CMGC | 4f7n | A | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(5-hydroxypentyl)urea | Human | 3847 | 0.50 | |||
| BRAF | RAF | TKL | 4jvg | D | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 3059 | 0.42 | |||
| PTK2B (PYK2) | FAK | TK | 3fzs | A | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 94 | 0.42 | |||
| PTK2B (PYK2) | FAK | TK | 3fzt | A | 1-[5-tert-butyl-2-(4-methylphenyl)-1,2-dihydro-3h-pyrazol-3-ylidene]-3-{3-[(pyridin-3-yloxy)methyl]-1h-pyrazol-5-yl}urea | Human | 86 | 0.42 | |||
| CDK8 | CDK | CMGC | 4f6s | A | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]urea | Human | 3848 | 0.42 | |||
| MAPK9 (JNK2) | MAPK | CMGC | 3npc | B | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 1237 | 0.42 | |||
| MAPK14 (p38a) | MAPK | CMGC | 3lfb | A | A | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(1,3-thiazol-2-yl)urea | Human | 4998 | 0.41 | ||
| MAPK14 (p38a) | MAPK | CMGC | 3hv6 | A | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[4-(2-morpholin-4-ylethoxy)phenyl]urea | Human | 5101 | 0.44 | |||
| MAPK14 (p38a) | MAPK | CMGC | 2yiw | A | 1-(3-tert-butyl-1-phenyl-1h-pyrazol-5-yl)-3-(2-{[3-(1-methylethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]sulfanyl}benzyl)urea | Human | 4988 | 0.40 | |||
| MAPK14 (p38a) | MAPK | CMGC | 9cj5 | A | pexmetinib | Human | 15698 | 1.00 | |||
| MAPK14 (p38a) | MAPK | CMGC | 1kv2 | A | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 5255 | 0.42 | |||
| MAPK14 (p38a) | MAPK | CMGC | 9cj4 | A | C | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 15706 | 0.42 | ||
| CDK8 | CDK | CMGC | 4f6w | A | n-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-4-[2-({[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]carbamoyl}amino)ethyl]piperazine-1-carboxamide | Human | 3845 | 0.48 | |||
| CDK8 | CDK | CMGC | 4f7l | A | tert-butyl [3-({[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]carbamoyl}amino)propyl]carbamate | Human | 3840 | 0.50 | |||
| CDK8 | CDK | CMGC | 4f6u | A | B | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(morpholin-4-yl)propyl]urea | Human | 3844 | 0.46 | ||
| PTK2B (PYK2) | FAK | TK | 4h1j | A | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(4-methoxy-2-methylphenyl)-1h-pyrazol-5-yl]urea | Human | 91 | 0.40 | |||
| STK10 (LOK) | STE20 | STE | 6gtt | A | B | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 10025 | 0.42 | ||
| EPHA3 (EphA3) | Eph | TK | 4twn | A | A | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 2846 | 0.42 | ||
| MAP3K7 (TAK1) | MLK | TKL | 2yiy | A | (1e)-1-[5-tert-butyl-2-(3-fluorophenyl)-1h-pyrazol-3-ylidene]-3-(4-pyridin-3-yloxyphenyl)urea | Human | 1890 | 0.40 | |||
| MAPK14 (p38a) | MAPK | CMGC | 3lfb | A | B | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(1,3-thiazol-2-yl)urea | Human | 5001 | 0.41 | ||
| MAPK14 (p38a) | MAPK | CMGC | 2yis | A | 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1h-pyrazol-5-yl]-3-{2-[(3-{2-[(2-hydroxyethyl)sulfanyl]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)sulfanyl]benzyl}urea | Human | 5240 | 0.41 | |||
| MAPK14 (p38a) | MAPK | CMGC | 9cj4 | A | A | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 15703 | 0.42 | ||
| MAPK14 (p38a) | MAPK | CMGC | 5n66 | A | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 8524 | 0.42 | |||
| MAPK14 (p38a) | MAPK | CMGC | 9cj4 | A | B | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 15704 | 0.42 | ||
| PTK2 (FAK) | FAK | TK | 4kao | B | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[4-(pyridin-3-yl)phenyl]urea | Human | 253 | 0.40 | |||
| PTK2 (FAK) | FAK | TK | 4kao | A | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[4-(pyridin-3-yl)phenyl]urea | Human | 248 | 0.40 | |||
| MAPK9 (JNK2) | MAPK | CMGC | 3npc | A | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 1235 | 0.42 | |||
| TTK | TTK | Other | 5ehl | A | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]urea | Human | 7256 | 0.42 | |||
| BRAF | RAF | TKL | 4jvg | C | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 3050 | 0.42 |
Pexmetinib
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