KLIFS - the structural kinase database

Searching for structures with analogs of Capivasertib.

Search results (18 entries covering 10 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
BTK	Tec	TK	7n4q	A	A	(2r)-2-(3-chloro-5-fluoroanilino)-2-cyclopropyl-n-[(3r)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]acetamide	Human	14227	0.40
BTK	Tec	TK	7n4q	A	B	(2r)-2-(3-chloro-5-fluoroanilino)-2-cyclopropyl-n-[(3r)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]acetamide	Human	14224	0.40
JAK3	JakA	TK	5ttu	A	B	1-[(3ar,7ar)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)octahydro-6h-pyrrolo[2,3-c]pyridin-6-yl]propan-1-one	Human	7438	0.44
AKT2	Akt	AGC	2x39	A		4-amino-n-(4-chlorobenzyl)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	Human	1913	0.68
JAK3	JakA	TK	7c3n	A	B	3-[(3s,4r)-3-methyl-7-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile	Human	12391	0.46
BTK	Tec	TK	8flg	A	B	n~2~-(3-chlorophenyl)-n-[(3r)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]glycinamide	Human	14634	0.43
BTK	Tec	TK	8flg	A	A	n~2~-(3-chlorophenyl)-n-[(3r)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]glycinamide	Human	14641	0.43
JAK3	JakA	TK	5ttu	A	A	1-[(3ar,7ar)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)octahydro-6h-pyrrolo[2,3-c]pyridin-6-yl]propan-1-one	Human	7435	0.44
JAK3	JakA	TK	7c3n	A	A	3-[(3s,4r)-3-methyl-7-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile	Human	12389	0.46
AKT1	Akt	AGC	4gv1	A	B	4-amino-n-[(1s)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	Human	2536	1.00
AKT1	Akt	AGC	3ocb	B		(2s)-2-(4-chlorobenzyl)-3-oxo-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]propan-1-amine	Human	2534	0.57
AKT1	Akt	AGC	3ocb	A		(2s)-2-(4-chlorobenzyl)-3-oxo-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]propan-1-amine	Human	2548	0.57
AKT2	Akt	AGC	2xh5	A		4-(4-tert-butylbenzyl)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium	Human	1924	0.47
JAK3	JakA	TK	7c3n	A	C	3-[(3s,4r)-3-methyl-7-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile	Human	12390	0.46
MAPK1 (Erk2)	MAPK	CMGC	6qaw	A	B	[1-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methylazanium	Human	10986	0.45
MAPK1 (Erk2)	MAPK	CMGC	6qaw	A	A	[1-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methylazanium	Human	10984	0.45
AKT1	Akt	AGC	4gv1	A	A	4-amino-n-[(1s)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	Human	2543	1.00
PRKACA (PKACa)	PKA	AGC	9dc6	A		n-(2-aminoethyl)-4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-3,4-dihydro-2h-1,4-thiazine-6-carboxamide	Human	15743	0.41