| IRAK4 | IRAK | TKL | 8dks | A | B | (1s,2s,3r,4r)-3-({2-[3-(pyrrolidine-1-carbonyl)anilino]thieno[3,2-d]pyrimidin-4-yl}amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide | Human | 14315 | 0.45 | |
| IRAK4 | IRAK | TKL | 8dks | A | A | (1s,2s,3r,4r)-3-({2-[3-(pyrrolidine-1-carbonyl)anilino]thieno[3,2-d]pyrimidin-4-yl}amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide | Human | 14316 | 0.45 | |
| EGFR | EGFR | TK | 6jrx | A | | n-{trans-4-[3-(2-chlorophenyl)-7-{[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]cyclohexyl}propanamide | Human | 12157 | 0.44 | |
| EGFR | EGFR | TK | 5zto | A | | n-{trans-4-[3-(2-chlorophenyl)-7-{[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]cyclohexyl}propanamide | Human | 11070 | 0.44 | |
| EGFR | EGFR | TK | 6jrk | A | | 6-(2-chloranyl-3-fluoranyl-phenyl)-5-methyl-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[(3s)-1-propanoylpiperidin-3-yl]pyrido[2,3-d]pyrimidin-7-one | Human | 12159 | 0.44 | |
| EGFR | EGFR | TK | 6jrj | A | | 6-(2-chloranyl-3-fluoranyl-phenyl)-5-methyl-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[(3s)-1-propanoylpiperidin-3-yl]pyrido[2,3-d]pyrimidin-7-one | Human | 12158 | 0.44 | |
| JAK2 | JakA | TK | 6vng | B | | n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide | Human | 13341 | 0.41 | |
| JAK2 | JakA | TK | 6vnf | B | B | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13352 | 0.41 | |
| JAK2 | JakA | TK | 6vnh | B | | n-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide | Human | 13342 | 0.43 | |
| JAK2 | JakA | TK | 6vnf | B | A | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13346 | 0.41 | |
| JAK2 | JakA | TK | 6vnh | A | | n-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide | Human | 13344 | 0.43 | |
| JAK2 | JakA | TK | 4ji9 | B | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 3724 | 0.43 | |
| JAK2 | JakA | TK | 5hez | C | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7253 | 0.43 | |
| JAK2 | JakA | TK | 6vni | A | | 2-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-1lambda~6~,2-thiazolidine-1,1-dione | Human | 13294 | 0.42 | |
| JAK2 | JakA | TK | 6vnf | A | A | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13347 | 0.41 | |
| JAK2 | JakA | TK | 5hez | D | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7252 | 0.43 | |
| JAK2 | JakA | TK | 6vnl | D | | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13297 | 0.41 | |
| JAK2 | JakA | TK | 6vnl | B | | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13299 | 0.41 | |
| JAK2 | JakA | TK | 5hez | B | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7255 | 0.43 | |
| JAK2 | JakA | TK | 6vnl | C | | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13300 | 0.41 | |
| JAK2 | JakA | TK | 5hez | A | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7254 | 0.43 | |
| JAK2 | JakA | TK | 4ji9 | A | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 3692 | 0.43 | |
| JAK2 | JakA | TK | 6vnf | A | B | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13357 | 0.41 | |
| JAK2 | JakA | TK | 6vng | A | | n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide | Human | 13358 | 0.41 | |
| JAK2 | JakA | TK | 6vnl | A | | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13303 | 0.41 | |
| WEE1 (Wee1) | WEE | Other | 5vd7 | A | | 6-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 9782 | 0.40 | |
| EGFR | EGFR | TK | 7er2 | A | | 5-chloranyl-n2-[3-chloranyl-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-n4-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine | Human | 14194 | 0.41 | |
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