KLIFS - the structural kinase database

Searching for structures with analogs of Naquotinib.

Search results (14 entries covering 11 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
EGFR	EGFR	TK	7lg8	A		6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3r)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazine-2-carboxamide	Human	14120	1.00
EGFR	EGFR	TK	5uga	A	A	4-(4-{[2-{[(3s)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9h-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium	Human	7517	0.42
FLT3	PDGFR	TK	6jqr	A		6-ethyl-3-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide	Human	11802	0.56
MAP2K7	STE7	STE	6yg3	A	A	n-(4-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide	Human	12689	0.43
MAP2K7	STE7	STE	6yg3	A	B	n-(4-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide	Human	12681	0.43
EGFR	EGFR	TK	5ugb	A		4-(4-{[2-{[(3s)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9h-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium	Human	7515	0.42
MERTK (MER)	Axl	TK	7ab1	A		6-ethyl-3-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide	Human	12933	0.56
EGFR	EGFR	TK	5uga	A	B	4-(4-{[2-{[(3s)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9h-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium	Human	7511	0.42
EGFR	EGFR	TK	5y9t	A		6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3r)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazine-2-carboxamide	Human	10053	1.00
MAP3K7 (TAK1)	MLK	TKL	5j8i	A		n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide	Human	7428	0.42
JAK2	JakA	TK	8bx6	A	A	cerdulatinib	Human	15033	0.40
JAK2	JakA	TK	8bx6	A	B	cerdulatinib	Human	15042	0.40
MAP3K7 (TAK1)	MLK	TKL	5jh6	A		2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl prop-2-enoate	Human	7427	0.42
MAP3K7 (TAK1)	MLK	TKL	5j9l	A		n-(4-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide	Human	7426	0.43