| PKN1 | PKN | AGC | 4oti | A | B | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 547 | 1.00 | |
| PKN1 | PKN | AGC | 4oti | A | A | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 551 | 1.00 | |
| JAK2 | JakA | TK | 5tq6 | A | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}(pyrrolidin-1-yl)methanone | Human | 7354 | 0.72 | |
| JAK2 | JakA | TK | 5tq6 | B | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}(pyrrolidin-1-yl)methanone | Human | 7361 | 0.72 | |
| JAK1 | JakA | TK | 3eyg | A | A | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 1445 | 1.00 | |
| JAK1 | JakA | TK | 3eyg | A | B | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 1453 | 1.00 | |
| JAK1 | JakA | TK | 4i5c | A | A | 3-oxo-3-[(3r)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridin-1(6h)-yl)piperidin-1-yl]propanenitrile | Human | 1446 | 0.56 | |
| JAK1 | JakA | TK | 4i5c | B | B | 3-oxo-3-[(3r)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridin-1(6h)-yl)piperidin-1-yl]propanenitrile | Human | 1458 | 0.56 | |
| JAK1 | JakA | TK | 4i5c | B | A | 3-oxo-3-[(3r)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridin-1(6h)-yl)piperidin-1-yl]propanenitrile | Human | 1467 | 0.56 | |
| TYK2 | JakA | TK | 3lxn | A | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 3337 | 1.00 | |
| JAK2 | JakA | TK | 4e6d | B | A | 3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile | Human | 3631 | 0.50 | |
| JAK2 | JakA | TK | 3fup | B | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 3654 | 1.00 | |
| JAK2 | JakA | TK | 4e6d | B | B | 3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile | Human | 3647 | 0.50 | |
| JAK2 | JakA | TK | 4e6d | A | A | 3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile | Human | 3689 | 0.50 | |
| JAK2 | JakA | TK | 3fup | A | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 3721 | 1.00 | |
| JAK3 | JakA | TK | 5ttu | A | A | 1-[(3ar,7ar)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)octahydro-6h-pyrrolo[2,3-c]pyridin-6-yl]propan-1-one | Human | 7435 | 0.46 | |
| JAK3 | JakA | TK | 5ttu | A | B | 1-[(3ar,7ar)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)octahydro-6h-pyrrolo[2,3-c]pyridin-6-yl]propan-1-one | Human | 7438 | 0.46 | |
| JAK3 | JakA | TK | 5tts | A | | 1-{(3r)-3-[(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}propan-1-one | Human | 7439 | 0.47 | |
| JAK3 | JakA | TK | 3lxk | A | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 436 | 1.00 | |
| JAK1 | JakA | TK | 4i5c | A | B | 3-oxo-3-[(3r)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridin-1(6h)-yl)piperidin-1-yl]propanenitrile | Human | 1471 | 0.56 | |
| JAK2 | JakA | TK | 4e6d | A | B | 3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile | Human | 3656 | 0.50 | |
| JAK1 | JakA | TK | 5khx | A | A | ~{n}-[3-[methyl(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | Human | 7167 | 0.40 | |
| JAK1 | JakA | TK | 5khx | A | B | ~{n}-[3-[methyl(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | Human | 7166 | 0.40 | |
| JAK3 | JakA | TK | 5toz | A | | 1-{(2s,5r)-2-methyl-5-[(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}propan-1-one | Human | 7163 | 0.42 | |
| JAK2 | JakA | TK | 5tq7 | B | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}[(3r)-3-(phenylsulfonyl)pyrrolidin-1-yl]methanone | Human | 7353 | 0.62 | |
| JAK2 | JakA | TK | 5tq7 | A | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}[(3r)-3-(phenylsulfonyl)pyrrolidin-1-yl]methanone | Human | 7355 | 0.62 | |
| JAK2 | JakA | TK | 6bbv | A | | n-{cis-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | Human | 9504 | 0.41 | |
| JAK1 | JakA | TK | 6bbu | A | A | n-{cis-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | Human | 9497 | 0.41 | |
| JAK1 | JakA | TK | 6bbu | A | B | n-{cis-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | Human | 9496 | 0.41 | |
| JAK3 | JakA | TK | 7c3n | A | B | 3-[(3s,4r)-3-methyl-7-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile | Human | 12391 | 0.50 | |
| JAK3 | JakA | TK | 7c3n | A | C | 3-[(3s,4r)-3-methyl-7-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile | Human | 12390 | 0.50 | |
| JAK3 | JakA | TK | 7c3n | A | A | 3-[(3s,4r)-3-methyl-7-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile | Human | 12389 | 0.50 | |
Match: