KLIFS - the structural kinase database

Searching for structures with analogs of Lenvatinib.

Search results (16 entries covering 11 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
SLK	STE20	STE	8bem	A	B	tivozanib	Human	14486	0.54
KDR	VEGFR	TK	3wzd	A	B	4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide	Human	5350	1.00
SLK	STE20	STE	8bem	A	A	tivozanib	Human	14487	0.54
KDR	VEGFR	TK	3b8q	A		n-(4-chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	Human	5332	0.44
KDR	VEGFR	TK	3b8q	B		n-(4-chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	Human	5319	0.44
KDR	VEGFR	TK	2rl5	A		n-(4-chlorophenyl)-7-[(6,7-dimethoxyquinolin-4-yl)oxy]-2,3-dihydro-1,4-benzoxazine-4-carboxamide	Human	5348	0.42
KDR	VEGFR	TK	3b8r	B		n-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	Human	5341	0.56
KDR	VEGFR	TK	3b8r	A		n-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	Human	5327	0.56
KDR	VEGFR	TK	3wzd	A	A	4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide	Human	5325	1.00
KDR	VEGFR	TK	4ase	A		tivozanib	Human	5349	0.54
SYK	Syk	TK	3tuc	A		1-benzyl-n-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-2-oxo-1,2-dihydropyridine-3-carboxamide	Human	1195	0.40
SYK	Syk	TK	3tub	A		1-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-3-[(1r,2s)-2-phenylcyclopropyl]urea	Human	1179	0.50
FGFR1	FGFR	TK	4rwl	B		6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-n-methylnaphthalene-1-carboxamide	Human	3596	0.42
FGFR1	FGFR	TK	5zv2	A		4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide	Human	10055	1.00
FGFR1	FGFR	TK	5zv2	B		4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide	Human	10054	1.00
MET	Met	TK	3vw8	A		n-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamothioyl)-2-phenylacetamide	Human	2985	0.41