KLIFS - the structural kinase database

Searching for structures with analogs of -.

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
EGFR	EGFR	TK	5hg9	A	B	1-[(3r,4r)-3-[({2-[(1-methyl-1h-pyrazol-4-yl)amino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-(trifluoromethyl)pyrrolidin-1-yl]propan-1-one	Human	6377	0.48
EGFR	EGFR	TK	5hg7	A		1-{(3r,4r)-3-[({5-chloro-2-[(1-methyl-1h-pyrazol-4-yl)amino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}propan-1-one	Human	6367	0.81
EGFR	EGFR	TK	5hg9	A	A	1-[(3r,4r)-3-[({2-[(1-methyl-1h-pyrazol-4-yl)amino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-(trifluoromethyl)pyrrolidin-1-yl]propan-1-one	Human	6379	0.48
TTK	TTK	Other	7cil	A	B	4-(cyclohexylamino)-2-[(1-methylpyrazol-4-yl)amino]-7h-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	Human	13555	0.41
TTK	TTK	Other	7cil	A	A	4-(cyclohexylamino)-2-[(1-methylpyrazol-4-yl)amino]-7h-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	Human	13549	0.41
MAP3K7 (TAK1)	MLK	TKL	5jk3	A		~{n}-[2-[5-chloranyl-2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide	Human	7430	0.44