| EGFR | EGFR | TK | 4i23 | A | | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 870 | 0.49 | |
| EGFR | EGFR | TK | 6tfy | A | B | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(3-oxidanylpropoxy)phenyl]propanamide | Human | 12841 | 0.48 | |
| EGFR | EGFR | TK | 4i24 | B | | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 910 | 0.49 | |
| EGFR | EGFR | TK | 4g5j | A | B | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 852 | 0.42 | |
| EGFR | EGFR | TK | 6tfy | B | A | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(3-oxidanylpropoxy)phenyl]propanamide | Human | 12847 | 0.48 | |
| EGFR | EGFR | TK | 2jiv | A | A | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 893 | 0.47 | |
| EGFR | EGFR | TK | 6tfv | A | B | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(2-hydroxyethyloxy)phenyl]propanamide | Human | 12832 | 0.48 | |
| EGFR | EGFR | TK | 3w2q | A | A | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 845 | 0.47 | |
| EGFR | EGFR | TK | 2jiv | B | A | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 830 | 0.47 | |
| EGFR | EGFR | TK | 3ug2 | A | A | gefitinib | Human | 898 | 0.51 | |
| EGFR | EGFR | TK | 2ity | A | | gefitinib | Human | 790 | 0.51 | |
| GAK | NAK | Other | 5y80 | A | A | gefitinib | Human | 10329 | 0.51 | |
| GAK | NAK | Other | 5y7z | A | | gefitinib | Human | 10332 | 0.51 | |
| EGFR | EGFR | TK | 6tfy | B | B | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(3-oxidanylpropoxy)phenyl]propanamide | Human | 12831 | 0.48 | |
| EGFR | EGFR | TK | 2jiv | A | B | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 851 | 0.47 | |
| GAK | NAK | Other | 5y80 | A | B | gefitinib | Human | 10330 | 0.51 | |
| EPHB4 (EphB4) | Eph | TK | 2vwu | A | | n-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine | Human | 370 | 0.40 | |
| EGFR | EGFR | TK | 6tfv | B | A | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(2-hydroxyethyloxy)phenyl]propanamide | Human | 12845 | 0.48 | |
| EGFR | EGFR | TK | 4i24 | A | | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 831 | 0.49 | |
| GAK | NAK | Other | 5y7z | B | | gefitinib | Human | 10331 | 0.51 | |
| EGFR | EGFR | TK | 4i22 | A | | gefitinib | Human | 823 | 0.51 | |
| EGFR | EGFR | TK | 3w2q | A | B | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 874 | 0.47 | |
| EGFR | EGFR | TK | 6tfy | A | A | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(3-oxidanylpropoxy)phenyl]propanamide | Human | 12825 | 0.48 | |
| EGFR | EGFR | TK | 4wkq | A | A | gefitinib | Human | 889 | 0.51 | |
| EGFR | EGFR | TK | 4g5p | A | | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 809 | 0.42 | |
| MAPK14 (p38a) | MAPK | CMGC | 4a9y | A | | n-(3-{[7-methoxy-6-(2-pyrrolidin-1-ylethoxy)quinazolin-4-yl]amino}-4-methylphenyl)-2-morpholin-4-ylisonicotinamide | Human | 5073 | 0.44 | |
| EGFR | EGFR | TK | 3ug2 | A | B | gefitinib | Human | 819 | 0.51 | |
| EGFR | EGFR | TK | 6tfv | B | B | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(2-hydroxyethyloxy)phenyl]propanamide | Human | 12827 | 0.48 | |
| EGFR | EGFR | TK | 6tfv | A | A | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(2-hydroxyethyloxy)phenyl]propanamide | Human | 12828 | 0.48 | |
| EGFR | EGFR | TK | 2ito | A | | gefitinib | Human | 783 | 0.51 | |
| MAPK14 (p38a) | MAPK | CMGC | 2bak | A | | n-(3-{[7-methoxy-6-(2-pyrrolidin-1-ylethoxy)quinazolin-4-yl]amino}-4-methylphenyl)-2-morpholin-4-ylisonicotinamide | Human | 5114 | 0.44 | |
| EGFR | EGFR | TK | 2itz | A | | gefitinib | Human | 789 | 0.51 | |
| MAP3K7 (TAK1) | MLK | TKL | 5j8i | A | | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | Human | 7428 | 0.41 | |
| EGFR | EGFR | TK | 2jiv | B | B | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 812 | 0.47 | |
| EGFR | EGFR | TK | 6tfw | A | | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-[2-(dimethylamino)ethoxy]phenyl]propanamide | Human | 12838 | 0.47 | |
| EGFR | EGFR | TK | 4wkq | A | B | gefitinib | Human | 837 | 0.51 | |
| EGFR | EGFR | TK | 4g5j | A | A | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 794 | 0.42 | |
| EGFR | EGFR | TK | 5y25 | A | | (2r)-n-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]-1-(2-fluoranylethanoyl)pyrrolidine-2-carboxamide | Human | 10373 | 0.52 | |
| EGFR | EGFR | TK | 6tfw | B | | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-[2-(dimethylamino)ethoxy]phenyl]propanamide | Human | 12837 | 0.47 | |
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