| KIT | PDGFR | TK | 6gql | A | | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide | Human | 10362 | 0.41 | |
| KIT | PDGFR | TK | 6gqk | A | B | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide | Human | 10353 | 0.42 | |
| KIT | PDGFR | TK | 6gqk | A | A | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide | Human | 10355 | 0.42 | |
| KIT | PDGFR | TK | 6gqj | B | B | 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide | Human | 10356 | 0.41 | |
| KIT | PDGFR | TK | 6gqk | B | B | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide | Human | 10360 | 0.42 | |
| EPHA2 (EphA2) | Eph | TK | 5ia4 | A | B | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 7168 | 0.42 | |
| AURKA (AurA) | Aur | Other | 2c6e | A | | n-{5-[(7-{[(2s)-2-hydroxy-3-piperidin-1-ylpropyl]oxy}-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide | Human | 1989 | 0.42 | |
| MET | Met | TK | 6sdc | A | A | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 11532 | 0.42 | |
| EGFR | EGFR | TK | 3ug2 | A | A | gefitinib | Human | 898 | 0.45 | |
| GAK | NAK | Other | 5y80 | A | A | gefitinib | Human | 10329 | 0.45 | |
| GAK | NAK | Other | 5y7z | A | | gefitinib | Human | 10332 | 0.45 | |
| STK10 (LOK) | STE20 | STE | 6i2y | B | | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 10788 | 0.42 | |
| GAK | NAK | Other | 5y7z | B | | gefitinib | Human | 10331 | 0.45 | |
| KDR | VEGFR | TK | 6gqo | A | B | 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide | Human | 10583 | 0.41 | |
| EGFR | EGFR | TK | 3ug2 | A | B | gefitinib | Human | 819 | 0.45 | |
| EGFR | EGFR | TK | 2ito | A | | gefitinib | Human | 783 | 0.45 | |
| EGFR | EGFR | TK | 2itz | A | | gefitinib | Human | 789 | 0.45 | |
| AURKA (AurA) | Aur | Other | 2c6e | B | | n-{5-[(7-{[(2s)-2-hydroxy-3-piperidin-1-ylpropyl]oxy}-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide | Human | 2046 | 0.42 | |
| GAK | NAK | Other | 5y80 | A | B | gefitinib | Human | 10330 | 0.45 | |
| EPHA2 (EphA2) | Eph | TK | 5ia4 | A | A | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 7189 | 0.42 | |
| EPHB4 (EphB4) | Eph | TK | 2vwu | A | | n-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine | Human | 370 | 0.46 | |
| KDR | VEGFR | TK | 6gqp | A | B | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide | Human | 10584 | 0.42 | |
| KDR | VEGFR | TK | 6gqq | A | A | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide | Human | 10581 | 0.41 | |
| KDR | VEGFR | TK | 6gqq | A | B | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide | Human | 10585 | 0.41 | |
| KDR | VEGFR | TK | 6gqp | A | A | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide | Human | 10582 | 0.42 | |
| KDR | VEGFR | TK | 6gqo | A | A | 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide | Human | 10580 | 0.41 | |
| MAPK14 (p38a) | MAPK | CMGC | 4a9y | A | | n-(3-{[7-methoxy-6-(2-pyrrolidin-1-ylethoxy)quinazolin-4-yl]amino}-4-methylphenyl)-2-morpholin-4-ylisonicotinamide | Human | 5073 | 0.46 | |
| MAPK14 (p38a) | MAPK | CMGC | 2bak | A | | n-(3-{[7-methoxy-6-(2-pyrrolidin-1-ylethoxy)quinazolin-4-yl]amino}-4-methylphenyl)-2-morpholin-4-ylisonicotinamide | Human | 5114 | 0.46 | |
| KIT | PDGFR | TK | 6gqj | A | B | 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide | Human | 10354 | 0.41 | |
| KIT | PDGFR | TK | 6gqj | A | A | 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide | Human | 10364 | 0.41 | |
| KIT | PDGFR | TK | 6gql | B | | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide | Human | 10357 | 0.41 | |
| KIT | PDGFR | TK | 6gqj | B | A | 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide | Human | 10358 | 0.41 | |
| EGFR | EGFR | TK | 4i22 | A | | gefitinib | Human | 823 | 0.45 | |
| EGFR | EGFR | TK | 4wkq | A | A | gefitinib | Human | 889 | 0.45 | |
| EGFR | EGFR | TK | 4wkq | A | B | gefitinib | Human | 837 | 0.45 | |
| EGFR | EGFR | TK | 2ity | A | | gefitinib | Human | 790 | 0.45 | |
| STK10 (LOK) | STE20 | STE | 6i2y | A | | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 10787 | 0.42 | |
| MET | Met | TK | 3lq8 | A | A | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 2998 | 0.42 | |
| MET | Met | TK | 3lq8 | A | B | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 2964 | 0.42 | |
| MET | Met | TK | 6sd9 | A | | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 11531 | 0.42 | |
| MET | Met | TK | 6sdc | A | B | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 11534 | 0.42 | |
| KIT | PDGFR | TK | 6gqk | B | A | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide | Human | 10363 | 0.42 | |
Match: